IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心
Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L
Yu, Fan1; Li, Jianlin1; Li, Hongxia1; Tang, Yongkai1; Wang, Meiyao1; Hu, Wei2; Yu, Juhua1
Corresponding AuthorYu, Fan(fan101@163.com) ; Yu, Juhua(yujh@ffrc.cn)
2018-11-02
Source PublicationBIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
ISSN1310-2818
Volume32Issue:6Pages:1440-1446
AbstractGlucose metabolism is a key biological process in animals, as it is related to multiple activities including immune response and diseases. In this study, we focused on serum parameter changes and hepatic gene expression to explore the immune response to glucose injection. We performed serum analysis and high-throughput sequencing analysis in the liver of common carp (Cyprinus carpio L). The serum GLU and albumin were up-regulated by glucose injection. The transcriptome analysis showed that the categories of response to external stimulus in GO category, PPAR-signalling pathway, complement and coagulation cascades pathways in KEGG analysis were enriched in genes that were differently expressed between the glucose injection group and the control group. Among these pathways, redox-regulatory protein FAM213A-like, extracellular superoxide dismutase [Cu-Zn]-like and putative natural resistance-associated macrophage protein (NRAMP) were up-regulated by glucose stimulation. The 25-hydroxyvitamin D-1 alpha hydroxylase, vitamin D 25-hydroxylase and natterin-3-like were significantly down-regulated by glucose injection. The present study is the first report of serum and hepatic transcriptome changes in common carp in response to glucose increase in serum. The obtained data provide valuable clues for future efforts into understanding the connection between the energy metabolism and the immune system.
KeywordCommon carp glucose serum transcriptome immune response
DOI10.1080/13102818.2018.1534554
Funding OrganizationNatural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes
Indexed BySCI ; SCI
Language英语
Funding ProjectNatural Science Foundation of Jiangsu Province[BK20151104] ; National Natural Science Foundation of China[31402281] ; National Natural Science Foundation of China[31872583] ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2018FB15] ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture[GXKEYLA2016-04] ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes[2015JBFR02]
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000461398900011
WOS KeywordDIETARY CARBOHYDRATE ; FISH NUTRITION ; VITAMIN-D ; METABOLISM ; INSULIN ; GROWTH ; TOLERANCE ; PROTEINS
PublisherTAYLOR & FRANCIS LTD
Funding OrganizationNatural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27904
Collection鱼类生物学及渔业生物技术研究中心
Corresponding AuthorYu, Fan; Yu, Juhua
Affiliation1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Yu, Fan,Li, Jianlin,Li, Hongxia,et al. Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L[J]. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,2018,32(6):1440-1446.
APA Yu, Fan.,Li, Jianlin.,Li, Hongxia.,Tang, Yongkai.,Wang, Meiyao.,...&Yu, Juhua.(2018).Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L.BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,32(6),1440-1446.
MLA Yu, Fan,et al."Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L".BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 32.6(2018):1440-1446.
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