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Natural gypenosides: targeting cancer through different molecular pathways
Ahmad, Bashir1,2; Khan, Suliman1,3,4; Nabi, Ghulam4,5; Gamallat, Yaser2; Su, Pengyu2; Jamalat, Yazeed2; Duan, Pengfei1,3; Yao, Lunguang1,3
Corresponding AuthorNabi, Ghulam(ghulamnabiqau@gmail.com) ; Yao, Lunguang(lunguangyao@163.com)
2019
Source PublicationCANCER MANAGEMENT AND RESEARCH
ISSN1179-1322
Volume11Pages:2287-2297
AbstractThe second foremost cause of mortality around the word is cancer. Conventional therapies, such as radiation, surgery, and chemotherapy have limited accessibility owing to secondary resistance. Therefore, convenient, safe, and nonresistant drugs are urgently needed. Plant-derived natural products have attracted considerable interest owing to their high efficacy, low toxicity, and convenience. Gypenosides (Gyp) inhibit invasion, migration, metastasis, and proliferation and induce apoptosis in different cancers, including oral, lung, colorectal, hepatocellular, and leukemic cancers through different molecular pathways. This review summarizes Gyp studies on cancer to serve as a reference for further research and clinical trials.
Keywordcancer surgery chemotherapy radiation therapy Gyp oral lung leukemic colorectal hepatocellular
DOI10.2147/CMAR.S185232
Funding OrganizationNational Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Science Foundation of China[31870917] ; Scientific and Technological Research Project of Henan Province[182102110084]
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000463243300001
WOS KeywordNF-KAPPA-B ; ENDOPLASMIC-RETICULUM STRESS ; GYNOSTEMMA-PENTAPHYLLUM SAPONINS ; MITOCHONDRIA-DEPENDENT PATHWAYS ; INDUCED G0/G1 ARREST ; G2/M PHASE ARREST ; CELLS IN-VITRO ; MEDIATED APOPTOSIS ; SIGNALING PATHWAYS ; HERBAL MEDICINES
PublisherDOVE MEDICAL PRESS LTD
Funding OrganizationNational Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province ; Scientific and Technological Research Project of Henan Province
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27870
Collection其他
Corresponding AuthorNabi, Ghulam; Yao, Lunguang
Affiliation1.Nanyang Normal Univ, Henan Prov Engn Res Ctr Hlth Prod Livestock & Pou, Nanyang, Peoples R China
2.Dalian Med Univ, Coll Basic Med Sci, Dalian, Peoples R China
3.Nanyang Normal Univ, Sch Agr Engn, Collaborat Innovat Ctr Water Secur Water Source R, Divers Project Henan Prov,Key Lab Ecol Secur Wate, Nanyang, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, 7 South Rd East Lake, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Ahmad, Bashir,Khan, Suliman,Nabi, Ghulam,et al. Natural gypenosides: targeting cancer through different molecular pathways[J]. CANCER MANAGEMENT AND RESEARCH,2019,11:2287-2297.
APA Ahmad, Bashir.,Khan, Suliman.,Nabi, Ghulam.,Gamallat, Yaser.,Su, Pengyu.,...&Yao, Lunguang.(2019).Natural gypenosides: targeting cancer through different molecular pathways.CANCER MANAGEMENT AND RESEARCH,11,2287-2297.
MLA Ahmad, Bashir,et al."Natural gypenosides: targeting cancer through different molecular pathways".CANCER MANAGEMENT AND RESEARCH 11(2019):2287-2297.
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