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Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits
Hua, Xiaoliang; Chen, Juan; Xu, Yujie; Li, Bing1
Corresponding AuthorLi, Bing(bingli@hust.edu.cn)
2019-04-01
Source PublicationUROLOGY
ISSN0090-4295
Volume126Pages:209-215
AbstractOBJECTIVE To investigate the efficacy of a combined dorsal plus ventral double tunica vaginalis graft for urethral reconstruction in a rabbit model through radiology and histopathology. METHODS Thirty adult male New Zealand rabbits were randomly divided into 6 groups as follows (n = 5): normal, stricture, and experimental groups A, B, C, and D. In the stricture and experimental groups, the ventral urethra was incised longitudinally, and the dorsal and ventral urethral mucosa were partially removed. Then, 3 x 20 mm and 5 x 20 mm tunica vaginalis grafts were obtained to repair the dorsal and ventral urethral mucosa defects, respectively, and the spongiosum was closed in the experimental groups. The urethral defects were not repaired in the stricture group. The rabbits in experimental groups A, B, C, and D were sacrificed at 2 weeks, 4 weeks, 12 weeks, and 24 weeks postoperatively, respectively, and the rabbits in the stricture group were sacrificed at 4 weeks postoperatively. The urethra was harvested for histological analysis. Urethrography was performed before sacrifice in the stricture group and experimental groups B and D. RESULTS The retrograde urethrogram showed that all rabbits in experimental groups B and D had a patent urethra. Histological examination showed that the tunica vaginalis graft completely integrated into the urethra at 4 weeks postoperatively and transformed into a urinary pseudostratified epithelium at 12 weeks postoperatively. CONCLUSION Combined dorsal plus ventral double tunica vaginalis graft urethroplasty is a feasible technique for urethral reconstruction in a rabbit model. (C) 2019 Elsevier Inc.
DOI10.1016/j.urology.2018.10.058
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC)
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[81671216] ; National Natural Science Foundation of China (NSFC)[81371379]
WOS Research AreaUrology & Nephrology
WOS SubjectUrology & Nephrology
WOS IDWOS:000462587200051
WOS KeywordURETHRAL STRICTURE DISEASE ; TERM-FOLLOW-UP ; BULBAR URETHROPLASTY ; MUCOSA GRAFT ; ONLAY ; OUTCOMES ; HARVEST
PublisherELSEVIER SCIENCE INC
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC)
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27844
Collection其他
Corresponding AuthorLi, Bing
Affiliation1.Huazhong Univ Sci & Technol, Dept Urol, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China
2.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Wannan Med Coll, Affiliated Hosp 1, Dept Urol, Wuhu 241001, Peoples R China
Recommended Citation
GB/T 7714
Hua, Xiaoliang,Chen, Juan,Xu, Yujie,et al. Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits[J]. UROLOGY,2019,126:209-215.
APA Hua, Xiaoliang,Chen, Juan,Xu, Yujie,&Li, Bing.(2019).Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits.UROLOGY,126,209-215.
MLA Hua, Xiaoliang,et al."Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits".UROLOGY 126(2019):209-215.
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