| Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates | |
| He, Yuming1,2; Pan, Hailin2,3,4; Zhang, Guojie2,3,4; He, Shunping5 | |
| Corresponding Author | Zhang, Guojie(zhanggj@genomics.cn) ; He, Shunping(clad@ihb.ac.cn) |
| 2019-04-01 | |
| Source Publication | SCIENCE CHINA-LIFE SCIENCES
 |
| ISSN | 1674-7305 |
| Volume | 62Issue:4Pages:566-578 |
| Abstract | Pattern recognition receptors (PRRs) play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns. The main four PRRs components including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and C-type lectin receptors (CLRs) were surveyed in the five genomes of non-teleost ray-finned fishes (NTR) including bichir (Polypterus senegalus), American paddlefish (Polyodon spathula), alligator gar (Atractosteus spatula), spotted gar (Lepisosteus oculatus) and bowfin (Amia calva), representing all the four major basal groups of ray-finned fishes. The result indicates that all the four PRRs components have been well established in these NTR fishes. In the RLR-MAVS signal pathway, which detects intracellular RNA ligands to induce production of type I interferons (IFNs), the MAVS was lost in bichir particularly. Also, the essential genes of recognition of Lipopolysaccharide (LPS) commonly in mammals like MD2, LY96 and LBP could not be identified in NTR fishes. It is speculated that TLR4 in NTR fishes may act as a cooperator with other PRRs and has a different pathway of recognizing LPS compared with that in mammals. In addition, we provide a survey of NLR and CLR in NTR fishes. The CLRs results suggest that Group V receptors are absent in fishes and Group II and VI receptors are well established in the early vertebrate evolution. Our comprehensive research of PRRs involving NTR fishes provides a new insight into PRR evolution in primitive vertebrate. |
| Keyword | pattern recognition receptors (PRR) Toll-like receptors (TLR) RIG-I-like receptors (RLR) C-type lectin receptors (CLR) NOD-like receptors (NLR) innate immunity |
| DOI | 10.1007/s11427-019-9481-8 |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31372190] |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics |
| WOS Subject | Biology |
| WOS ID | WOS:000464901000013 |
| WOS Keyword | TOLL-LIKE RECEPTOR ; ANTIVIRAL SIGNALING PROTEIN ; GENOME PROVIDES INSIGHTS ; IMMUNE GENE REPERTOIRE ; C-TYPE LECTINS ; NF-KAPPA-B ; EXPRESSION ANALYSIS ; CHANNEL CATFISH ; MOLECULAR CHARACTERIZATION ; LIPOPOLYSACCHARIDE LPS |
| Publisher | SCIENCE PRESS |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/27751 |
| Collection | 水生生物多样性与资源保护研究中心 |
| Corresponding Author | Zhang, Guojie; He, Shunping |
| Affiliation | 1.Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen 518083, Peoples R China 2.BGI Shenzhen, China Natl Genebank, Shenzhen 518083, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China 4.Univ Copenhagen, Dept Biol, Ctr Social Evolut, Univ Pk 15, DK-2100 Copenhagen, Denmark 5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | He, Yuming,Pan, Hailin,Zhang, Guojie,et al. Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates[J]. SCIENCE CHINA-LIFE SCIENCES,2019,62(4):566-578. |
| APA | He, Yuming,Pan, Hailin,Zhang, Guojie,&He, Shunping.(2019).Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates.SCIENCE CHINA-LIFE SCIENCES,62(4),566-578. |
| MLA | He, Yuming,et al."Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates".SCIENCE CHINA-LIFE SCIENCES 62.4(2019):566-578. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment