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Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates
He, Yuming1,2; Pan, Hailin2,3,4; Zhang, Guojie2,3,4; He, Shunping5
Corresponding AuthorZhang, Guojie(zhanggj@genomics.cn) ; He, Shunping(clad@ihb.ac.cn)
2019-04-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
Volume62Issue:4Pages:566-578
AbstractPattern recognition receptors (PRRs) play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns. The main four PRRs components including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and C-type lectin receptors (CLRs) were surveyed in the five genomes of non-teleost ray-finned fishes (NTR) including bichir (Polypterus senegalus), American paddlefish (Polyodon spathula), alligator gar (Atractosteus spatula), spotted gar (Lepisosteus oculatus) and bowfin (Amia calva), representing all the four major basal groups of ray-finned fishes. The result indicates that all the four PRRs components have been well established in these NTR fishes. In the RLR-MAVS signal pathway, which detects intracellular RNA ligands to induce production of type I interferons (IFNs), the MAVS was lost in bichir particularly. Also, the essential genes of recognition of Lipopolysaccharide (LPS) commonly in mammals like MD2, LY96 and LBP could not be identified in NTR fishes. It is speculated that TLR4 in NTR fishes may act as a cooperator with other PRRs and has a different pathway of recognizing LPS compared with that in mammals. In addition, we provide a survey of NLR and CLR in NTR fishes. The CLRs results suggest that Group V receptors are absent in fishes and Group II and VI receptors are well established in the early vertebrate evolution. Our comprehensive research of PRRs involving NTR fishes provides a new insight into PRR evolution in primitive vertebrate.
Keywordpattern recognition receptors (PRR) Toll-like receptors (TLR) RIG-I-like receptors (RLR) C-type lectin receptors (CLR) NOD-like receptors (NLR) innate immunity
DOI10.1007/s11427-019-9481-8
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31372190]
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000464901000013
WOS KeywordTOLL-LIKE RECEPTOR ; ANTIVIRAL SIGNALING PROTEIN ; GENOME PROVIDES INSIGHTS ; IMMUNE GENE REPERTOIRE ; C-TYPE LECTINS ; NF-KAPPA-B ; EXPRESSION ANALYSIS ; CHANNEL CATFISH ; MOLECULAR CHARACTERIZATION ; LIPOPOLYSACCHARIDE LPS
PublisherSCIENCE PRESS
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27751
Collection水生生物多样性与资源保护研究中心
Corresponding AuthorZhang, Guojie; He, Shunping
Affiliation1.Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen 518083, Peoples R China
2.BGI Shenzhen, China Natl Genebank, Shenzhen 518083, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
4.Univ Copenhagen, Dept Biol, Ctr Social Evolut, Univ Pk 15, DK-2100 Copenhagen, Denmark
5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
He, Yuming,Pan, Hailin,Zhang, Guojie,et al. Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates[J]. SCIENCE CHINA-LIFE SCIENCES,2019,62(4):566-578.
APA He, Yuming,Pan, Hailin,Zhang, Guojie,&He, Shunping.(2019).Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates.SCIENCE CHINA-LIFE SCIENCES,62(4),566-578.
MLA He, Yuming,et al."Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates".SCIENCE CHINA-LIFE SCIENCES 62.4(2019):566-578.
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