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Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men
Ullah, Hamid1; Nabi, Ghulam1,2,3; Zubair, Hira1; Ullah, Rahim1,4; Shahab, Muhammad1
Corresponding AuthorShahab, Muhammad(shahab@qau.edu.pk)
2019-05-01
Source PublicationANDROLOGIA
ISSN0303-4569
Volume51Issue:4Pages:9
AbstractThe present study was designed to assess the responsiveness of hypothalamic-pituitary-gonadal axis to kisspeptin administration with increasing age in men. Human kisspeptin-10 was administered in single iv bolus dose (1 mu g/kg BW) to healthy adult, middle and advanced age men. Serial blood samples were collected for 30 min pre- and 120 min post-kisspeptin injection periods at 30-min interval. Analysis of plasma LH by ELISA showed a significant (p < 0.05) increase after kisspeptin-10 administration in all groups, whereas plasma testosterone concentration was significantly elevated (p < 0.05) after kisspeptin-10 injection only in the adult men group. Present results suggest that in men, central hypothalamic-pituitary axis remains active and shows responsiveness to kisspeptin stimulation across life. However, Leydig cell responsiveness to kisspeptin-induced LH decreases with age in men.
Keywordhypothalamus kisspeptin pituitary reproduction testes
DOI10.1111/and.13219
Funding OrganizationHigher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan
Indexed BySCI ; SCI
Language英语
Funding ProjectHigher Education Commission, Pakistan
WOS Research AreaEndocrinology & Metabolism
WOS SubjectAndrology
WOS IDWOS:000463161400004
WOS KeywordGONADOTROPIN-RELEASING-HORMONE ; PITUITARY-TESTICULAR AXIS ; LUTEINIZING-HORMONE ; TESTOSTERONE SECRETION ; INFUNDIBULAR NUCLEUS ; NEGATIVE FEEDBACK ; GENE-EXPRESSION ; GNRH RECEPTOR ; GONADAL AXIS ; LEPTIN
PublisherWILEY
Funding OrganizationHigher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27723
Collection其他
Corresponding AuthorShahab, Muhammad
Affiliation1.Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Lab Reprod Neuroendocrinol, Islamabad, Pakistan
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Zhejiang Univ, Childrens Hosp, Sch Med, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Ullah, Hamid,Nabi, Ghulam,Zubair, Hira,et al. Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men[J]. ANDROLOGIA,2019,51(4):9.
APA Ullah, Hamid,Nabi, Ghulam,Zubair, Hira,Ullah, Rahim,&Shahab, Muhammad.(2019).Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men.ANDROLOGIA,51(4),9.
MLA Ullah, Hamid,et al."Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men".ANDROLOGIA 51.4(2019):9.
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