| Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men | |
| Ullah, Hamid1; Nabi, Ghulam1,2,3; Zubair, Hira1; Ullah, Rahim1,4; Shahab, Muhammad1 | |
| Corresponding Author | Shahab, Muhammad(shahab@qau.edu.pk) |
| 2019-05-01 | |
| Source Publication | ANDROLOGIA
 |
| ISSN | 0303-4569 |
| Volume | 51Issue:4Pages:9 |
| Abstract | The present study was designed to assess the responsiveness of hypothalamic-pituitary-gonadal axis to kisspeptin administration with increasing age in men. Human kisspeptin-10 was administered in single iv bolus dose (1 mu g/kg BW) to healthy adult, middle and advanced age men. Serial blood samples were collected for 30 min pre- and 120 min post-kisspeptin injection periods at 30-min interval. Analysis of plasma LH by ELISA showed a significant (p < 0.05) increase after kisspeptin-10 administration in all groups, whereas plasma testosterone concentration was significantly elevated (p < 0.05) after kisspeptin-10 injection only in the adult men group. Present results suggest that in men, central hypothalamic-pituitary axis remains active and shows responsiveness to kisspeptin stimulation across life. However, Leydig cell responsiveness to kisspeptin-induced LH decreases with age in men. |
| Keyword | hypothalamus kisspeptin pituitary reproduction testes |
| DOI | 10.1111/and.13219 |
| Funding Organization | Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| Funding Project | Higher Education Commission, Pakistan |
| WOS Research Area | Endocrinology & Metabolism |
| WOS Subject | Andrology |
| WOS ID | WOS:000463161400004 |
| WOS Keyword | GONADOTROPIN-RELEASING-HORMONE ; PITUITARY-TESTICULAR AXIS ; LUTEINIZING-HORMONE ; TESTOSTERONE SECRETION ; INFUNDIBULAR NUCLEUS ; NEGATIVE FEEDBACK ; GENE-EXPRESSION ; GNRH RECEPTOR ; GONADAL AXIS ; LEPTIN |
| Publisher | WILEY |
| Funding Organization | Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan ; Higher Education Commission, Pakistan |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/27723 |
| Collection | 其他 |
| Corresponding Author | Shahab, Muhammad |
| Affiliation | 1.Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Lab Reprod Neuroendocrinol, Islamabad, Pakistan 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Zhejiang Univ, Childrens Hosp, Sch Med, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China |
| Recommended Citation GB/T 7714 | Ullah, Hamid,Nabi, Ghulam,Zubair, Hira,et al. Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men[J]. ANDROLOGIA,2019,51(4):9. |
| APA | Ullah, Hamid,Nabi, Ghulam,Zubair, Hira,Ullah, Rahim,&Shahab, Muhammad.(2019).Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men.ANDROLOGIA,51(4),9. |
| MLA | Ullah, Hamid,et al."Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men".ANDROLOGIA 51.4(2019):9. |
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