IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心
Identification and expression analysis of IL-4/13 receptors in grass carp Ctenopharyngodon idella
Jiang, Xinyu1,2,3; Gao, Jingduo1,2,3; Xue, Yujie1,2,3; Qin, Yuting1,2,3; Li, Xia1,2,3; Sun, Zhaosheng1,2,3; Xie, Haixia4; Chang, Mingxian4; Nie, Pin4; Zou, Jun1,2,3,5; Gao, Qian1,2,3
Corresponding AuthorZou, Jun(jzou@shou.edu.cn) ; Gao, Qian(qgao@shou.edu.cn)
2019-04-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume87Pages:254-264
AbstractInterleukin (IL)-4 and IL-13 are T helper 2 (Th2) cytokines with pleiotropic functions. IL-4 interacts with two receptors consisting of IL-4R alpha/gamma chain receptor (gamma C) and IL-4R alpha/IL-13R alpha 1. In contrast, IL-13 binds to IL-13R alpha 2 but also shares the receptor complex containing IL-4R alpha/IL-13R alpha 1. In fish, two IL-4/13 homologs have been identified but their phylogenetic relationships with IL-4 and IL-13 are ambiguous. In this study, we identified six putative IL-4/13 receptor homologs in grass carp, including gamma Ci, gamma C2, IL-4R alpha 1, IL-13R alpha 1, IL-13R alpha 2 and a soluble form of IL-4R alpha 2. Comparative sequence analyses revealed that these receptors possess conserved characteristic domains and the genes encoding them share conserved gene synteny with their human counterparts. All six receptors contain a cytokine binding homology domain (CHD) and two fibronectin type III (FNIII) like domains, with IL-13R alpha 1 and IL-13R alpha 2 harbouring an extra Ig-like domain preceding the CHD domain. Interestingly, grass carp IL-13R alpha 1 and IL-13R alpha 2 lack the characteristic WSXWS motif, a typical feature of mammalian type I cytokine receptors. The IL-4/13 receptor genes are differentially expressed in tissues and primary leukocytes of head kidney and can be modulated by Fiavobacterium cloumnare (F. clownnare), suggesting they are involved in immune response against F. cloumnare infection.
KeywordInterleukin IL-4/13 receptor Cytokine Carp
DOI10.1016/j.fsi.2019.01.009
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China
Indexed BySCI ; SCI
Language英语
Funding ProjectNational Natural Science Foundation of China[U1605211and 31272666] ; State Key Laboratory of Freshwater Ecology and Biotechnology of China[Y119011F01]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000464086600029
WOS KeywordSIGNAL-TRANSDUCTION ; LIGAND-BINDING ; CYTOKINE ; IL-13 ; COMMON ; INTERLEUKIN-13 ; IL-13R-ALPHA-2 ; MODULATION ; MECHANISM ; EVOLUTION
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27704
Collection鱼类生物学及渔业生物技术研究中心
Corresponding AuthorZou, Jun; Gao, Qian
Affiliation1.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China
2.Shanghai Ocean Univ, Int Res Ctr Marine Biosci, Minist Sci & Technol, Shanghai, Peoples R China
3.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai, Peoples R China
4.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Xinyu,Gao, Jingduo,Xue, Yujie,et al. Identification and expression analysis of IL-4/13 receptors in grass carp Ctenopharyngodon idella[J]. FISH & SHELLFISH IMMUNOLOGY,2019,87:254-264.
APA Jiang, Xinyu.,Gao, Jingduo.,Xue, Yujie.,Qin, Yuting.,Li, Xia.,...&Gao, Qian.(2019).Identification and expression analysis of IL-4/13 receptors in grass carp Ctenopharyngodon idella.FISH & SHELLFISH IMMUNOLOGY,87,254-264.
MLA Jiang, Xinyu,et al."Identification and expression analysis of IL-4/13 receptors in grass carp Ctenopharyngodon idella".FISH & SHELLFISH IMMUNOLOGY 87(2019):254-264.
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