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RNAi mediated myosuppressin deficiency affects muscle development and survival in the salmon louse (Lepeophtheirus salmonis)
Komisarczuk, Anna Z.1; Kongshaug, Heidi1; Li, Ming2,3; Nilsen, Frank1
2019-05-06
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume9Issue:1Pages:18
Abstract

Muscle activity is regulated by stimulatory and inhibitory neuropeptides allowing for contraction and relaxation. In Arthropods, one of the important myoinhibitors is Myosuppressin, belonging to FMRFamide-like peptides, that was shown to have inhibitory effects on visceral muscle contraction and to regulate vital physiological processes including reproduction or feeding. We have identified myosuppressin in salmon louse Lepeophtheirus salmonis (LsalMS) and systematically characterised its function and complex abnormalities emerging after LsalMS knockdown by RNAi in all developmental stages in this species. Immunohistochemistry analysis localized the LsalMS mainly to the central nervous system, but also to the vital organs within the alimentary tract and the reproductive system. The most striking feature of LsalMS deficiency during lice development was severe reduction of the muscle content, with abnormalities detected in both the visceral and skeletal muscles. Moreover, down-regulation of LsalMS affects moulting, spermatophore deposition and feeding by affecting development of the intestinal wall and increasing its contraction frequency.

DOI10.1038/s41598-019-43515-w
Funding OrganizationResearch Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre
Indexed BySCI
Language英语
Funding ProjectResearch Council of Norway, SFI-Sea Lice Research Centre[203513/O30]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000466878900044
WOS KeywordDROSOPHILA-MELANOGASTER MYOTROPINS ; FMRFAMIDE-RELATED PEPTIDES ; SCALLOP PECTEN-MAXIMUS ; BLOOD-FEEDING BUG ; SEA-LICE ; INSECT NEUROPEPTIDES ; SCHISTOFLRF-AMIDE ; SKELETAL-MUSCLE ; PK/PBAN FAMILY ; ALPHA-AMYLASE
PublisherNATURE PUBLISHING GROUP
Funding OrganizationResearch Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre ; Research Council of Norway, SFI-Sea Lice Research Centre
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27583
Collection水生生物多样性与资源保护研究中心
Corresponding AuthorKomisarczuk, Anna Z.
Affiliation1.Univ Bergen, Sea Lice Res Ctr, Dept Biol Sci, Thormohlensgate 53A-B, N-5008 Bergen, Norway
2.Chinese Acad Sci, Key Lab Aquaculture Dis Control, Minist Agr, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
3.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Komisarczuk, Anna Z.,Kongshaug, Heidi,Li, Ming,et al. RNAi mediated myosuppressin deficiency affects muscle development and survival in the salmon louse (Lepeophtheirus salmonis)[J]. SCIENTIFIC REPORTS,2019,9(1):18.
APA Komisarczuk, Anna Z.,Kongshaug, Heidi,Li, Ming,&Nilsen, Frank.(2019).RNAi mediated myosuppressin deficiency affects muscle development and survival in the salmon louse (Lepeophtheirus salmonis).SCIENTIFIC REPORTS,9(1),18.
MLA Komisarczuk, Anna Z.,et al."RNAi mediated myosuppressin deficiency affects muscle development and survival in the salmon louse (Lepeophtheirus salmonis)".SCIENTIFIC REPORTS 9.1(2019):18.
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