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题名: Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides
作者: Lv, Ziyu1; Li, Xiuling2; Chen, Zhonghui1; Chen, Ji3; Chen, Cheng2; Xiong, Peng1; Sun, Taolei1, 4; Qing, Guangyan1
关键词: surface stiffness ; viscoelasticity ; stimuli-responsive films ; chiral separation ; tissue engineering
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2015-12-16
DOI: 10.1021/acsami.5b08405
卷: 7, 期:49, 页:27223-27233
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science
英文摘要: Surface stiffness is considered a key parameter for designing high-performance implantable materials and artificial extracellular matrices because of its substantial effects on cell behavior. How to transform biomolecule recognition events, particularly chiral recognition, into stiffness change on material surfaces is biologically essential but very challenging for chemists. Here, we report a chirality-triggered stiffness transition on a smart polymer film, which consists of flexible polyethylenimine (PEI) main chains grafted with dipeptide units capable of discriminating chiral monosaccharides. The polymer film became substantially softer after interacting with L-ribose and became more rigid after interacting with D-ribose (the basic building block of DNA and RNA). This chiral effect provides a new method for determining the enantiomeric purity of an L/D-ribose mixture and facilitates the chiral separation of deoxyribose racemates as well as the separation of diverse mono-, di-, and oligosaccharides. These are three puzzle problems in carbohydrate chemistry. Furthermore, taking advantage of the significant differences in the surface stiffness, the proliferation of fibroblast cells on the polymeric surfaces can also be regulated by chiral biomolecules.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; QUARTZ-CRYSTAL MICROBALANCE ; STEM-CELL FATE ; SUBSTRATE STIFFNESS ; ENANTIOMERIC EXCESS ; INTERFACE ; POLYMER ; ADHESION ; MANIPULATION ; NANOFIBRILS
语种: 英语
项目资助者: Major State Basic Research Development Program of China (973 Program)(2013CB933002) ; National Natural Science Foundation of China(21104061 ; China National Funds for Distinguished Young Scientists(51325302) ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; 21275114 ; 51473131 ; 21475129 ; 91127027 ; 51173142)
WOS记录号: WOS:000366873900024
ISSN号: 1944-8244
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27512
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
4.Wuhan Univ Technol, Chem Engn & Life Sci, Sch Chem, Wuhan 430070, Peoples R China
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