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Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides
Lv, Ziyu1; Li, Xiuling2; Chen, Zhonghui1; Chen, Ji3; Chen, Cheng2; Xiong, Peng1; Sun, Taolei1,4; Qing, Guangyan1
2015-12-16
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume7Issue:49Pages:27223-27233
AbstractSurface stiffness is considered a key parameter for designing high-performance implantable materials and artificial extracellular matrices because of its substantial effects on cell behavior. How to transform biomolecule recognition events, particularly chiral recognition, into stiffness change on material surfaces is biologically essential but very challenging for chemists. Here, we report a chirality-triggered stiffness transition on a smart polymer film, which consists of flexible polyethylenimine (PEI) main chains grafted with dipeptide units capable of discriminating chiral monosaccharides. The polymer film became substantially softer after interacting with L-ribose and became more rigid after interacting with D-ribose (the basic building block of DNA and RNA). This chiral effect provides a new method for determining the enantiomeric purity of an L/D-ribose mixture and facilitates the chiral separation of deoxyribose racemates as well as the separation of diverse mono-, di-, and oligosaccharides. These are three puzzle problems in carbohydrate chemistry. Furthermore, taking advantage of the significant differences in the surface stiffness, the proliferation of fibroblast cells on the polymeric surfaces can also be regulated by chiral biomolecules.
SubtypeArticle
KeywordSurface Stiffness Viscoelasticity Stimuli-responsive Films Chiral Separation Tissue Engineering
DOI10.1021/acsami.5b08405
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
Funding OrganizationMajor State Basic Research Development Program of China (973 Program)(2013CB933002) ; Major State Basic Research Development Program of China (973 Program)(2013CB933002) ; National Natural Science Foundation of China(21104061 ; National Natural Science Foundation of China(21104061 ; China National Funds for Distinguished Young Scientists(51325302) ; China National Funds for Distinguished Young Scientists(51325302) ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; 21275114 ; 21275114 ; 51473131 ; 51473131 ; 21475129 ; 21475129 ; 91127027 ; 91127027 ; 51173142) ; 51173142) ; Major State Basic Research Development Program of China (973 Program)(2013CB933002) ; Major State Basic Research Development Program of China (973 Program)(2013CB933002) ; National Natural Science Foundation of China(21104061 ; National Natural Science Foundation of China(21104061 ; China National Funds for Distinguished Young Scientists(51325302) ; China National Funds for Distinguished Young Scientists(51325302) ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; 21275114 ; 21275114 ; 51473131 ; 51473131 ; 21475129 ; 21475129 ; 91127027 ; 91127027 ; 51173142) ; 51173142)
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; QUARTZ-CRYSTAL MICROBALANCE ; STEM-CELL FATE ; SUBSTRATE STIFFNESS ; ENANTIOMERIC EXCESS ; INTERFACE ; POLYMER ; ADHESION ; MANIPULATION ; NANOFIBRILS
WOS IDWOS:000366873900024
Funding OrganizationMajor State Basic Research Development Program of China (973 Program)(2013CB933002) ; Major State Basic Research Development Program of China (973 Program)(2013CB933002) ; National Natural Science Foundation of China(21104061 ; National Natural Science Foundation of China(21104061 ; China National Funds for Distinguished Young Scientists(51325302) ; China National Funds for Distinguished Young Scientists(51325302) ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; 21275114 ; 21275114 ; 51473131 ; 51473131 ; 21475129 ; 21475129 ; 91127027 ; 91127027 ; 51173142) ; 51173142) ; Major State Basic Research Development Program of China (973 Program)(2013CB933002) ; Major State Basic Research Development Program of China (973 Program)(2013CB933002) ; National Natural Science Foundation of China(21104061 ; National Natural Science Foundation of China(21104061 ; China National Funds for Distinguished Young Scientists(51325302) ; China National Funds for Distinguished Young Scientists(51325302) ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; Hubei Provincial Department of Education through "Chutian Scholar" Program ; 21275114 ; 21275114 ; 51473131 ; 51473131 ; 21475129 ; 21475129 ; 91127027 ; 91127027 ; 51173142) ; 51173142)
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27512
Collection鱼类生物学及渔业生物技术研究中心
Affiliation1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
4.Wuhan Univ Technol, Chem Engn & Life Sci, Sch Chem, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Lv, Ziyu,Li, Xiuling,Chen, Zhonghui,et al. Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(49):27223-27233.
APA Lv, Ziyu.,Li, Xiuling.,Chen, Zhonghui.,Chen, Ji.,Chen, Cheng.,...&Qing, Guangyan.(2015).Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides.ACS APPLIED MATERIALS & INTERFACES,7(49),27223-27233.
MLA Lv, Ziyu,et al."Surface Stiffness-a Parameter for Sensing the Chirality of Saccharides".ACS APPLIED MATERIALS & INTERFACES 7.49(2015):27223-27233.
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