中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
题名: Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus
作者: Fan, Yuding1, 4; Chang, Ming Xian2; Ma, Jie1; LaPatra, Scott E.3; Hu, Yi Wei2; Huang, Lili1; Nie, Pin2; Zeng, Lingbing1
刊名: VETERINARY RESEARCH
发表日期: 2015-11-20
DOI: 10.1186/s13567-015-0279-8
卷: 46
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Veterinary Sciences
研究领域[WOS]: Veterinary Sciences
英文摘要: The emergence of an infectious viral disease caused by the Chinese giant salamander iridovirus (GSIV) has led to substantial economic losses. However, no more molecular information is available for the understanding of the mechanisms associated with virus-host interaction. In this study, de novo sequencing was used to obtain abundant high-quality ESTs and investigate differentially-expressed genes in the spleen of Chinese giant salamanders that were either infected or mock infected with GSIV. Comparative expression analysis indicated that 293 genes were down-regulated and 220 genes were up-regulated. Further enrichment analysis showed that the most enriched pathway is "complement and coagulation cascades", and significantly enriched diseases include "inherited thrombophilia", "immune system diseases", "primary immunodeficiency", "complement regulatory protein defects", and "disorders of nucleotide excision repair". Additionally, 30 678 simple sequence repeats (SSRs) from all spleen samples, 26 355 single nucleotide polymorphisms (SNPs) from the spleens of uninfected animals and 36 070 SNPs from the spleens of infected animals were detected. The large amount of variation was specific for the Chinese giant salamanders that were infected with GSIV. The results reported herein provided significant and new EST information that could contribute greatly in investigations into the molecular functions of immune genes in the Chinese giant salamander.
关键词[WOS]: TOLL-LIKE RECEPTORS ; NOD-LIKE RECEPTORS ; IMMUNE GENE REPERTOIRE ; RNA-SEQ DATA ; INNATE IMMUNITY ; FUNCTIONAL-CHARACTERIZATION ; REFERENCE GENOME ; CHANNEL CATFISH ; SPLICE VARIANTS ; EXPRESSION
语种: 英语
项目资助者: Special Fund for Agro-scientific Research in the Public Interest(201203086)
WOS记录号: WOS:000365161200003
ISSN号: 0928-4249
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27399
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus.pdf(3271KB)----开放获取--View Download

作者单位: 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
3.Clear Springs Foods Inc, Div Res, Buhl, ID 83316 USA
4.Huazhong Agr Univ, Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan 430223, Hubei, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Fan, Yuding]'s Articles
[Chang, Ming Xian]'s Articles
[Ma, Jie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Fan, Yuding]‘s Articles
[Chang, Ming Xian]‘s Articles
[Ma, Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院水生生物研究所 - Feedback
Powered by CSpace