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题名: Effects of Tris(1,3-dichloro-2-propyl) Phosphate on Growth, Reproduction, and Gene Transcription of Daphnia magna at Environmentally Relevant Concentrations
作者: Lij, Han1; Su, Guanyong2, 3; Zou, Ming1; Yu, Liqin1; Letcher, Robert J.3; Yu, Hongxia2; Giesy, John P.2, 4, 5, 6, 7; Zhou, Bingsheng8; Liu, Chunsheng1
刊名: ENVIRONMENTAL SCIENCE & TECHNOLOGY
发表日期: 2015-11-03
DOI: 10.1021/acs.est.5b03294
卷: 49, 期:21, 页:12975-12983
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Technology ; Life Sciences & Biomedicine
类目[WOS]: Engineering, Environmental ; Environmental Sciences
研究领域[WOS]: Engineering ; Environmental Sciences & Ecology
英文摘要: The synthetic flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been frequently detected in natural waters, and its maximum concentration ever reported is 377 ng/L. However, information on the adverse effects of environmentally relevant concentrations of TDCIPP on aquatic organisms are totally unknown. In this study, <12-h old water fleas, D. magna, were exposed to concentrations of 0, 65 +/- 7.1, 550 +/- 33, or 6500 +/- 1400 ng/L TDCIPP, and dose- and time-dependent effects on reproduction and development were evaluated. Sequences of genes of D. magna were obtained from the National Center for Biotechnology Information and were used to develop PCR arrays for D. magna. Arrays were then used to study transcriptional responses of D. magna to TDCIPP. Exposure to environmentally relevant concentrations of TDCIPP significantly decreased fecundity as well as length of F-0 and F-1 generations. Transcriptional responses showed that, of the 155 genes tested, expressions of 57 genes were significantly changed, and some changes occurred following exposure to environmentally relevant concentrations (i.e., 65 +/- 7.1 and 550 +/- 23 ng/L). Furthermore, pathways related to protein synthesis and metabolism and endocytosis were considered to be significantly affected in a dose- and time-dependent manner and might be responsible for TDCIPP-induced reproductive and developmental toxicities.
关键词[WOS]: ORGANOPHOSPHATE FLAME RETARDANTS ; MESSENGER-RNA EXPRESSION ; MASS-SPECTROMETRY METHOD ; ZEBRAFISH DANIO-RERIO ; ENDOCRINE DISRUPTION ; DEVELOPMENTAL EXPOSURE ; CHICKEN EMBRYOS ; SURFACE WATERS ; IN-VITRO ; TDCPP
语种: 英语
项目资助者: Fundamental Research Funds for the Central Universities(2662015PY036) ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation(2014RC001) ; Environmental Monitoring Funds of Jiangsu Province(1405) ; Canada Research Chair program ; State Administration of Foreign Experts Affairs ; P.R. China ; Chinese Academy of Sciences ; Natural Science and Engineering Research Council of Canada(326415-07) ; Western Economic Diversification Canada(6578 ; Canada Foundation for Infrastructure ; 6807 ; 000012711)
WOS记录号: WOS:000364355300043
ISSN号: 0013-936X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27358
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
2.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210089, Jiangsu, Peoples R China
3.Carleton Univ, Dept Chem, Ottawa, ON K1S 5B6, Canada
4.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B3, Canada
5.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada
6.Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA
7.Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA
8.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
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