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题名: The Role of Glutathione Detoxification Pathway in MCLR-Induced Hepatotoxicity in SD Rats
作者: Li, Shangchun1, 2; Chen, Jun1; Xie, Ping1; Guo, Xiaochun1, 3; Fan, Huihui1, 3; Yu, Dezhao1, 2; Zeng, Cheng1, 3; Chen, Liang1, 2
关键词: microcystin-LR ; glutathione ; oxidative stress ; liver ; BSO ; SD rat
刊名: ENVIRONMENTAL TOXICOLOGY
发表日期: 2015-12-01
DOI: 10.1002/tox.22017
卷: 30, 期:12, 页:1470-1480
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]: Environmental Sciences ; Toxicology ; Water Resources
研究领域[WOS]: Environmental Sciences & Ecology ; Toxicology ; Water Resources
英文摘要: In the present study, we investigated the role of glutathione (GSH) and its related enzymes in Sprague Dawley (SD) rats subjected to microcystin-leucine-arginine (MCLR)-induced hepatotoxicity. SD rats were intraperitoneally (i.p.) injected with MCLR after pretreating with or without buthionine-(S,R)-sulfoximine (BSO), an inhibitor of GSH synthesis. The depletion of GSH with BSO enhanced MCLR-induced oxidative stress, resulting in more severe liver damage and higher MCLR accumulation. Similarly, the contents of malondialdehyde (MDA), total GSH (T-GSH), oxidized GSH (GSSG) and GSH were significantly enhanced in BSO pretreated rats following MCLR treatment. The study showed that the transcription of GSH-related enzymes such as glutathione-S-transferase (GST), gamma-glutamylcysteine synthetase (gamma-GCS), glutathione reductase (GR) varied in different ways (expect for glutathione peroxidase (GPx), whose gene expression was induced in all treated groups) with or without BSO pretreatment before MCLR exposure, suggesting an adaptative response of GSH-related enzymes at transcription level to combat enhancement of oxidative stress induced by MCLR when pretreated with BSO. These data suggested the tissues with low GSH concentration are highly vulnerable to MCLR toxicity and GSH was critical for the detoxification in MCLR-induced hepatotoxicity in vivo. (C) 2014 Wiley Periodicals, Inc.
关键词[WOS]: INDUCED DNA-DAMAGE ; MICROCYSTIN-LR ; OXIDATIVE STRESS ; CYANOBACTERIAL TOXINS ; ANTIOXIDANT ENZYMES ; HUMAN HEALTH ; IN-VIVO ; LIVER ; TOXICITY ; EXPOSURE
语种: 英语
项目资助者: National Natural Science Foundations of China ; (31070457)
WOS记录号: WOS:000364781900012
ISSN号: 1520-4081
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27356
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
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