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题名: Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily
作者: Xiong, Jie1; Feng, Jinmei1; Yuan, Dongxia1; Zhou, Jun2; Miao, Wei1
刊名: SCIENTIFIC REPORTS
发表日期: 2015-11-18
DOI: 10.1038/srep16724
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: The ATP binding cassette (ABC) transporters superfamily is one of the largest classes of membrane proteins. The core of the ABC transporter protein is composed of transmembrane domains (TMDs) and nucleotide binding domains (NBD). Eukaryotes ABC transporters are classified into seven main families (ABCA to ABCG) based on sequence similarity and domain organizations. With different domain number and domain organizations, eukaryote ABC transporters show diverse structures: the single structure (NBD or TMD), the ABC2 structure (NBD-NBD), the half structure (TMD-NBD or NBD-TMD) and the full structure (TMD-NBD-TMD-NBD or NBD-TMD-NBD-TMD). However, studies on how various ABC transporter gene structures evolved is still absent. Therefore, in this study, we comprehensively investigated the structural evolution of eukaryotic ABC transporters. The seven eukaryote ABC transporter families (A to G) fell into three groups: A& G group, B, C& D group and E& F group. There were at least four times the number of NBD and TMD fusion events in the origin of the half structure transporter. Two fusion modes were found in the full and ABC2 structure origination. Based on these findings, we present a putative structural evolutionary path of eukaryote ABC transporters that will increase our understanding on their origin, divergence and function.
关键词[WOS]: MULTIPLE SEQUENCE ALIGNMENT ; ABC TRANSPORTER ; GENE DUPLICATION ; ESCHERICHIA-COLI ; CAENORHABDITIS-ELEGANS ; DRUG-RESISTANCE ; ARGININE KINASE ; FAMILY ; FUSION ; OPERON
语种: 英语
项目资助者: Projects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Natural Science Foundation of China(31372168 ; 31301930)
WOS记录号: WOS:000364843900001
ISSN号: 2045-2322
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27353
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
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