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Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily
Xiong, Jie1; Feng, Jinmei1; Yuan, Dongxia1; Zhou, Jun2; Miao, Wei1
2015-11-18
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume5
AbstractThe ATP binding cassette (ABC) transporters superfamily is one of the largest classes of membrane proteins. The core of the ABC transporter protein is composed of transmembrane domains (TMDs) and nucleotide binding domains (NBD). Eukaryotes ABC transporters are classified into seven main families (ABCA to ABCG) based on sequence similarity and domain organizations. With different domain number and domain organizations, eukaryote ABC transporters show diverse structures: the single structure (NBD or TMD), the ABC2 structure (NBD-NBD), the half structure (TMD-NBD or NBD-TMD) and the full structure (TMD-NBD-TMD-NBD or NBD-TMD-NBD-TMD). However, studies on how various ABC transporter gene structures evolved is still absent. Therefore, in this study, we comprehensively investigated the structural evolution of eukaryotic ABC transporters. The seven eukaryote ABC transporter families (A to G) fell into three groups: A& G group, B, C& D group and E& F group. There were at least four times the number of NBD and TMD fusion events in the origin of the half structure transporter. Two fusion modes were found in the full and ABC2 structure origination. Based on these findings, we present a putative structural evolutionary path of eukaryote ABC transporters that will increase our understanding on their origin, divergence and function.
SubtypeArticle
DOI10.1038/srep16724
WOS HeadingsScience & Technology
Funding OrganizationProjects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Projects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Natural Science Foundation of China(31372168 ; Natural Science Foundation of China(31372168 ; 31301930) ; 31301930) ; Projects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Projects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Natural Science Foundation of China(31372168 ; Natural Science Foundation of China(31372168 ; 31301930) ; 31301930)
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000364843900001
WOS KeywordMULTIPLE SEQUENCE ALIGNMENT ; ABC TRANSPORTER ; GENE DUPLICATION ; ESCHERICHIA-COLI ; CAENORHABDITIS-ELEGANS ; DRUG-RESISTANCE ; ARGININE KINASE ; FAMILY ; FUSION ; OPERON
Funding OrganizationProjects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Projects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Natural Science Foundation of China(31372168 ; Natural Science Foundation of China(31372168 ; 31301930) ; 31301930) ; Projects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Projects of International Cooperation and Exchanges, Ministry of Science and Technology of China(2013DFG32390) ; Natural Science Foundation of China(31372168 ; Natural Science Foundation of China(31372168 ; 31301930) ; 31301930)
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27353
Collection水生生物分子与细胞生物学研究中心_期刊论文
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
Recommended Citation
GB/T 7714
Xiong, Jie,Feng, Jinmei,Yuan, Dongxia,et al. Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily[J]. SCIENTIFIC REPORTS,2015,5.
APA Xiong, Jie,Feng, Jinmei,Yuan, Dongxia,Zhou, Jun,&Miao, Wei.(2015).Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily.SCIENTIFIC REPORTS,5.
MLA Xiong, Jie,et al."Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily".SCIENTIFIC REPORTS 5(2015).
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