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题名: Interferon regulatory factor 10 (IRF10): Cloning in orange spotted grouper, Epinephelus coioides, and evolutionary analysis in vertebrates
作者: Huang, Bei1; Jia, Qin Qin1; Liang, Ying1; Huang, Wen Shu1; Nie, P.1, 2
关键词: IRF10 ; Orange spotted grouper ; Epinephelus coioides ; Evolution ; Vertebrate
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2015-10-01
DOI: 10.1016/j.fsi.2015.08.003
卷: 46, 期:2, 页:669-677
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
研究领域[WOS]: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
英文摘要: IRF10 gene was cloned in orange spotted grouper, Epinephelus coioides, and its expression was examined following poly(I:C) stimulation and bacterial infection. The cDNA sequence of grouper IRF10 contains an open reading frame of 1197 bp, flanked by 99 bp 5'-untranslated region and 480 bp 3'- untranslated region. Multiple alignments showed that the grouper IRF10 has a highly conserved DNA binding domain in the N terminus with characteristic motif containing five tryptophan residues. Quantitative real-time PCR analysis revealed that the expression of IRF10 was responsive to both poly(I:C) stimulation and Vibrio parahemolyticus infection, with a higher increase to poly(I:C), indicating an important role of IRF10 in host immune response during infection. A phyletic distribution of IRF members was also examined in vertebrates, and IRF10 was found in most lineages of vertebrates, not in modern primates and rodents. It is suggested that the first divergence of IRF members might have occurred before the evolutionary split of vertebrate and cephalochordates, producing ancestors of IRF (1/2/11) and IRF (4/8/9/10)[(3/7) (5/6)], and that the second and/or third divergence of IRF members occurred following the split, thus leading to the subsets of the IRF family in vertebrates. (C) 2015 Elsevier Ltd. All rights reserved.
关键词[WOS]: PROTEIN-PROTEIN INTERACTIONS ; COD GADUS-MORHUA ; TRANSCRIPTION FACTORS ; ONCORHYNCHUS-MYKISS ; MOLECULAR-CLONING ; CRYSTAL-STRUCTURE ; RAINBOW-TROUT ; DNA-SEQUENCES ; HOST-DEFENSE ; FAMILY
语种: 英语
项目资助者: National Natural Science Foundation of China(31402329 ; Natural Science Foundation of Fujian province(2012J06008) ; National 863 Program of China(2012AA092201) ; Science and Technology Program of Xiamen Southern Oceanographic Center(14PYY050SF03) ; 31172438)
WOS记录号: WOS:000363071200056
ISSN号: 1050-4648
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27338
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian Province, Peoples R China
2.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei Province, Peoples R China
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