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题名: A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish
作者: Jing, Jing1; Xiong, Shuting1; Li, Zhi2; Wu, Junjie1; Zhou, Li2; Gui, Jian-Fang1, 2; Mei, Jie1
刊名: SCIENTIFIC REPORTS
发表日期: 2015-10-28
DOI: 10.1038/srep15906
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: In vertebrates, growth hormone/insulin-like growth factor (GH/IGF) axis signaling plays a critical role in regulating somatic growth. Understanding the direct upstream regulators of GH/IGF axis remains a major challenge. Our studies of the zebrafish reveal that the conserved miR-200 family members are critical regulators of embryo size by targeting several GH/IGF axis genes, including GH, GHRa, GHRb and IGF2a. Overexpression of miR-200s led to cell cycle arrest in the G1 phase and induced apoptotic responses during embryo development, thereby inhibiting somatic growth of zebrafish embryos. Intriguingly, GH induced expression of both p53 and miR-200s, and miR-200s is a potential p53 transcriptional target, thus forming a negative feedback loop. Significantly, the up-regulation of miR-200s associated with GH activation is abolished in embryos with p53 mutation. By integrating these studies, we conclude that p53/miR-200 and GH/IGF signaling pathway form a negative regulatory loop to control embryo size, that provide critical insights into the long-standing puzzle of how body growth is determined during early development of teleosts.
关键词[WOS]: SERUM RESPONSE FACTOR ; MESSENGER-RNA LEVELS ; FACTOR-I ; GENE-EXPRESSION ; CELL-PROLIFERATION ; BODY-SIZE ; FAT-BODY ; TARGETS ; CARP ; DIFFERENTIATION
语种: 英语
项目资助者: National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52204-12018)
WOS记录号: WOS:000363529000001
ISSN号: 2045-2322
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27328
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Huazhong Agr Univ, Freshwater Aquaculture Collaborat Innovat Ctr Hub, Key Lab Freshwater Anim Breeding, Coll Fisheries,Minist Agr, Wuhan 430070, Peoples R China
2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
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