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A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish
Jing, Jing1; Xiong, Shuting1; Li, Zhi2; Wu, Junjie1; Zhou, Li2; Gui, Jian-Fang1,2; Mei, Jie1
2015-10-28
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume5Issue:1Pages:1-12
Abstract

In vertebrates, growth hormone/insulin-like growth factor (GH/IGF) axis signaling plays a critical role in regulating somatic growth. Understanding the direct upstream regulators of GH/IGF axis remains a major challenge. Our studies of the zebrafish reveal that the conserved miR-200 family members are critical regulators of embryo size by targeting several GH/IGF axis genes, including GH, GHRa, GHRb and IGF2a. Overexpression of miR-200s led to cell cycle arrest in the G1 phase and induced apoptotic responses during embryo development, thereby inhibiting somatic growth of zebrafish embryos. Intriguingly, GH induced expression of both p53 and miR-200s, and miR-200s is a potential p53 transcriptional target, thus forming a negative feedback loop. Significantly, the up-regulation of miR-200s associated with GH activation is abolished in embryos with p53 mutation. By integrating these studies, we conclude that p53/miR-200 and GH/IGF signaling pathway form a negative regulatory loop to control embryo size, that provide critical insights into the long-standing puzzle of how body growth is determined during early development of teleosts.

SubtypeArticle
DOI10.1038/srep15906
WOS HeadingsScience & Technology
Funding OrganizationNational Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018)
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000363529000001
WOS KeywordSERUM RESPONSE FACTOR ; MESSENGER-RNA LEVELS ; FACTOR-I ; GENE-EXPRESSION ; CELL-PROLIFERATION ; BODY-SIZE ; FAT-BODY ; TARGETS ; CARP ; DIFFERENTIATION
Funding OrganizationNational Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; National Natural Science Foundation of China(31301931) ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; Fundamental Research Funds for the Central Universities(2013PY068 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52902-0900202496 ; 52204-12018) ; 52204-12018) ; 52204-12018) ; 52204-12018)
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27328
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Affiliation1.Huazhong Agr Univ, Freshwater Aquaculture Collaborat Innovat Ctr Hub, Key Lab Freshwater Anim Breeding, Coll Fisheries,Minist Agr, Wuhan 430070, Peoples R China
2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Jing, Jing,Xiong, Shuting,Li, Zhi,et al. A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish[J]. SCIENTIFIC REPORTS,2015,5(1):1-12.
APA Jing, Jing.,Xiong, Shuting.,Li, Zhi.,Wu, Junjie.,Zhou, Li.,...&Mei, Jie.(2015).A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish.SCIENTIFIC REPORTS,5(1),1-12.
MLA Jing, Jing,et al."A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish".SCIENTIFIC REPORTS 5.1(2015):1-12.
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