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Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer
Xiong, Jie1; Wang, Guangying1,2; Cheng, Jun1,3; Tian, Miao1,2; Pan, Xuming4; Warren, Alan5; Jiang, Chuanqi1,2; Yuan, Dongxia1; Miao, Wei1
2015-10-21
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume5Issue:1Pages:1-12
Abstract

Certain ciliates of the subclass Scuticociliatia (scuticociliates) are facultative parasites of fishes in which they cause a suite of diseases collectively termed scuticociliatosis. Hitherto, comparatively little was known about genetics and genomics of scuticociliates or the mechanism of scuticociliatosis. In this study, a laboratory culture of the facultatively pathogenic scuticociliate Pseudocohnilembus persalinus was established and its genome sequenced, giving the first genome of a marine ciliate. Genome-wide horizontal gene transfer (HGT) analysis showed P. persalinus has acquired many unique prokaryote-derived genes that potentially contribute to the virulence of this organism, including cell adhesion, hemolysis and heme utilization genes. These findings give new insights into our understanding of the pathology of scuticociliates.

SubtypeArticle
DOI10.1038/srep15470
WOS HeadingsScience & Technology
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000363114000001
WOS KeywordFLOUNDER PARALICHTHYS-OLIVACEUS ; TURBOT SCOPHTHALMUS-MAXIMUS ; PHOSPHOLIPASE-C ; URONEMA-MARINUM ; PHILASTERIDES-DICENTRARCHI ; RNA-SEQ ; PLASMODIUM-FALCIPARUM ; STAPHYLOCOCCUS-AUREUS ; PROTECTIVE IMMUNITY ; HEMOLYSIN-III
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27278
Collection水生生物分子与细胞生物学研究中心_期刊论文
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangdong Ocean Univ, Zhanjiang 524088, Peoples R China
4.Harbin Normal Univ, Coll Life Sci & Technol, Dept Biol, Lab Protozool, Harbin 150025, Peoples R China
5.Nat Hist Museum, Dept Life Sci, London SW7 5BD, England
Recommended Citation
GB/T 7714
Xiong, Jie,Wang, Guangying,Cheng, Jun,et al. Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer[J]. SCIENTIFIC REPORTS,2015,5(1):1-12.
APA Xiong, Jie.,Wang, Guangying.,Cheng, Jun.,Tian, Miao.,Pan, Xuming.,...&Miao, Wei.(2015).Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer.SCIENTIFIC REPORTS,5(1),1-12.
MLA Xiong, Jie,et al."Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer".SCIENTIFIC REPORTS 5.1(2015):1-12.
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