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题名: Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish
作者: Xu, Tao1; Wang, Qiangwei2, 3; Shi, Qipeng2; Fang, Qi2; Guo, Yongyong2; Zhou, Bingsheng2
关键词: TDCPP ; Bioconcentration and metabolism ; Zebrafish ; Thyroid hormones
刊名: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
发表日期: 2015-09-01
DOI: 10.1016/j.etap.2015.08.020
卷: 40, 期:2, 页:581-586
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
英文摘要: Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate widely used as a flame retardant, and has frequently been detected in the environment and biota. The present study investigates the bioconcentration and metabolism of TDCPP in fish. Zebrafish embryos (from 2 h post-fertilization) were exposed to TDCPP (0, 4, 20 and 100 mu g/L) for six months. Exposure to TDCPP significantly induced phase I metabolic enzymes 7-ethoxyresorufin O-deethylase (EROD) and 7-methoxyresorufin 0-demethylase (MROD) in fish. The mRNA expression of genes related to Phase I and II metabolic enzymes, such as cyp1a1, cyp1b1, cyp1c1 and ugt1ab were also significantly upregulated. Exposure to TDCPP significantly reduced plasma thyroxine (T-4) and 3,5,3'-triiodothyronine (T-3) levels in females. Chemicals analysis indicated significant levels of TDCPP and its metabolite, bis (1,3-dichloro-2-propyl) phosphate (BDCPP), in the liver. The present study reveals that exposure to low concentrations of TDCPP can cause bioconcentration in fish, and TDCPP can be readily metabolized in liver. (C) 2015 Elsevier B.V. All rights reserved.
关键词[WOS]: ORGANOPHOSPHATE FLAME RETARDANTS ; MESSENGER-RNA EXPRESSION ; DEETHYLASE EROD ACTIVITY ; ENDOCRINE DISRUPTION ; IN-VITRO ; MASS-SPECTROMETRY ; CHICKEN EMBRYOS ; CELL-LINE ; HYDROCARBON ; RECEPTOR
语种: 英语
WOS记录号: WOS:000362619100033
ISSN号: 1382-6689
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27274
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Puwai Hosp, Wuhan 430033, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou 310058, Zhejiang, Peoples R China
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