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Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish
Xu, Tao1; Wang, Qiangwei2,3; Shi, Qipeng2; Fang, Qi2; Guo, Yongyong2; Zhou, Bingsheng2
2015-09-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume40Issue:2Pages:581-586
AbstractTris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate widely used as a flame retardant, and has frequently been detected in the environment and biota. The present study investigates the bioconcentration and metabolism of TDCPP in fish. Zebrafish embryos (from 2 h post-fertilization) were exposed to TDCPP (0, 4, 20 and 100 mu g/L) for six months. Exposure to TDCPP significantly induced phase I metabolic enzymes 7-ethoxyresorufin O-deethylase (EROD) and 7-methoxyresorufin 0-demethylase (MROD) in fish. The mRNA expression of genes related to Phase I and II metabolic enzymes, such as cyp1a1, cyp1b1, cyp1c1 and ugt1ab were also significantly upregulated. Exposure to TDCPP significantly reduced plasma thyroxine (T-4) and 3,5,3'-triiodothyronine (T-3) levels in females. Chemicals analysis indicated significant levels of TDCPP and its metabolite, bis (1,3-dichloro-2-propyl) phosphate (BDCPP), in the liver. The present study reveals that exposure to low concentrations of TDCPP can cause bioconcentration in fish, and TDCPP can be readily metabolized in liver. (C) 2015 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordTdcpp Bioconcentration And Metabolism Zebrafish Thyroid Hormones
DOI10.1016/j.etap.2015.08.020
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectEnvironmental Sciences ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000362619100033
WOS KeywordORGANOPHOSPHATE FLAME RETARDANTS ; MESSENGER-RNA EXPRESSION ; DEETHYLASE EROD ACTIVITY ; ENDOCRINE DISRUPTION ; IN-VITRO ; MASS-SPECTROMETRY ; CHICKEN EMBRYOS ; CELL-LINE ; HYDROCARBON ; RECEPTOR
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27274
Collection水环境工程研究中心_期刊论文
Affiliation1.Huazhong Univ Sci & Technol, Puwai Hosp, Wuhan 430033, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou 310058, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Xu, Tao,Wang, Qiangwei,Shi, Qipeng,et al. Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2015,40(2):581-586.
APA Xu, Tao,Wang, Qiangwei,Shi, Qipeng,Fang, Qi,Guo, Yongyong,&Zhou, Bingsheng.(2015).Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,40(2),581-586.
MLA Xu, Tao,et al."Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 40.2(2015):581-586.
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