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Whole-Genome Analysis of a Novel Fish Reovirus (MsReV) Discloses Aquareovirus Genomic Structure Relationship with Host in Saline Environments
Chen, Zhong-Yuan; Gao, Xiao-Chan; Zhang, Qi-Ya
2015-08-01
Source PublicationVIRUSES-BASEL
ISSN1999-4915
Volume7Issue:8Pages:4282-4302
AbstractAquareoviruses are serious pathogens of aquatic animals. Here, genome characterization and functional gene analysis of a novel aquareovirus, largemouth bass Micropterus salmoides reovirus (MsReV), was described. It comprises 11 dsRNA segments (S1-S11) covering 24,024 bp, and encodes 12 putative proteins including the inclusion forming-related protein NS87 and the fusion-associated small transmembrane (FAST) protein NS22. The function of NS22 was confirmed by expression in fish cells. Subsequently, MsReV was compared with two representative aquareoviruses, saltwater fish turbot Scophthalmus maximus reovirus (SMReV) and freshwater fish grass carp reovirus strain 109 (GCReV-109). MsReV NS87 and NS22 genes have the same structure and function with those of SMReV, whereas GCReV-109 is either missing the coiled-coil region in NS79 or the gene-encoding NS22. Significant similarities are also revealed among equivalent genome segments between MsReV and SMReV, but a difference is found between MsReV and GCReV-109. Furthermore, phylogenetic analysis showed that 13 aquareoviruses could be divided into freshwater and saline environments subgroups, and MsReV was closely related to SMReV in saline environments. Consequently, these viruses from hosts in saline environments have more genomic structural similarities than the viruses from hosts in freshwater. This is the first study of the relationships between aquareovirus genomic structure and their host environments.
SubtypeArticle
KeywordAquareovirus Genome Largemouth Bass Micropterus Salmoides Reovirus (Msrev) Fusion-associated Small Transmembrane (Fast) Protein Host Environments
DOI10.3390/v7082820
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaVirology
WOS SubjectVirology
WOS KeywordGRASS CARP REOVIRUS ; RANA-GRYLIO-VIRUS ; FAST PROTEIN ; AQUACULTURE ANIMALS ; GENUS AQUAREOVIRUS ; FAMILY REOVIRIDAE ; ENVELOPE PROTEIN ; SEQUENCE ; CHINA ; IDENTIFICATION
WOS IDWOS:000361604100006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27215
Collection鱼类生物学及渔业生物技术研究中心
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Chen, Zhong-Yuan,Gao, Xiao-Chan,Zhang, Qi-Ya. Whole-Genome Analysis of a Novel Fish Reovirus (MsReV) Discloses Aquareovirus Genomic Structure Relationship with Host in Saline Environments[J]. VIRUSES-BASEL,2015,7(8):4282-4302.
APA Chen, Zhong-Yuan,Gao, Xiao-Chan,&Zhang, Qi-Ya.(2015).Whole-Genome Analysis of a Novel Fish Reovirus (MsReV) Discloses Aquareovirus Genomic Structure Relationship with Host in Saline Environments.VIRUSES-BASEL,7(8),4282-4302.
MLA Chen, Zhong-Yuan,et al."Whole-Genome Analysis of a Novel Fish Reovirus (MsReV) Discloses Aquareovirus Genomic Structure Relationship with Host in Saline Environments".VIRUSES-BASEL 7.8(2015):4282-4302.
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