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题名: Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos
作者: Liu, Chunsheng2, 3; Yan, Wei4; Zhou, Bingsheng5; Guo, Yongyong5; Liu, Hongling2, 3; Yu, Hongxia2, 3; Giesy, John P.6, 7, 8, 9; Wang, Jianghua1; Li, Guangyu1, 5; Zhang, Xiaowei2, 3
关键词: Melanin synthesis ; Microinjection ; Bystander exposure ; Risk assessment
刊名: AQUATIC TOXICOLOGY
发表日期: 2012-08-15
DOI: 10.1016/j.aquatox.2012.04.001
卷: 118, 页:108-115
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
英文摘要: This study was conducted to evaluate possible bystander effects induced by the model chemical 6-propyl-2-thiouracil (PTU) on melanin synthesis. Zebrafish (Danio rerio) embryos were treated with PTU by either microinjection exposure, via waterborne exposure or indirectly through bystander exposure. Melanin content, related mRNA and protein expression were examined at the end of exposure (36 h post-fertilization). Direct exposure to FLU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (7YR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV. Bystander exposure also up-regulated mRNA and protein expressions of TYR and SILV but increased melanin contents. Correlation analysis demonstrated that mRNA expressions of OCA2, TYR, DCT, TYRP1, SILV and protein expressions of TYR and SILV in bystander exposure groups were positively correlated with corresponding expressions in microinjection exposure groups. The results might have environmental implications and highlight the need to consider the bystander effects when assessing potential risks of endocrine-disrupting chemicals. (C) 2012 Elsevier B.V. All rights reserved.
关键词[WOS]: RADIATION-INDUCED STRESS ; PITUITARY-GONADAL AXIS ; MEDAKA ORYZIAS-LATIPES ; COMMUNICATED IN-VIVO ; RAINBOW-TROUT ; GENE-EXPRESSION ; POMATOSCHISTUS-MINUTUS ; FISH BEHAVIOR ; SAND GOBY ; PCR ARRAY
语种: 英语
WOS记录号: WOS:000305102400012
ISSN号: 0166-445X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27130
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
2.Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210093, Peoples R China
3.Nanjing Univ, Sch Environm, Nanjing 210093, Peoples R China
4.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Wuhan 430064, Hubei, Peoples R China
5.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
6.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK, Canada
7.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK, Canada
8.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
9.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
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