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Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos
Liu, Chunsheng2,3; Yan, Wei4; Zhou, Bingsheng5; Guo, Yongyong5; Liu, Hongling2,3; Yu, Hongxia2,3; Giesy, John P.6,7,8,9; Wang, Jianghua1; Li, Guangyu1,5; Zhang, Xiaowei2,3
2012-08-15
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume118Pages:108-115
AbstractThis study was conducted to evaluate possible bystander effects induced by the model chemical 6-propyl-2-thiouracil (PTU) on melanin synthesis. Zebrafish (Danio rerio) embryos were treated with PTU by either microinjection exposure, via waterborne exposure or indirectly through bystander exposure. Melanin content, related mRNA and protein expression were examined at the end of exposure (36 h post-fertilization). Direct exposure to FLU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (7YR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV. Bystander exposure also up-regulated mRNA and protein expressions of TYR and SILV but increased melanin contents. Correlation analysis demonstrated that mRNA expressions of OCA2, TYR, DCT, TYRP1, SILV and protein expressions of TYR and SILV in bystander exposure groups were positively correlated with corresponding expressions in microinjection exposure groups. The results might have environmental implications and highlight the need to consider the bystander effects when assessing potential risks of endocrine-disrupting chemicals. (C) 2012 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordMelanin Synthesis Microinjection Bystander Exposure Risk Assessment
DOI10.1016/j.aquatox.2012.04.001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS KeywordRADIATION-INDUCED STRESS ; PITUITARY-GONADAL AXIS ; MEDAKA ORYZIAS-LATIPES ; COMMUNICATED IN-VIVO ; RAINBOW-TROUT ; GENE-EXPRESSION ; POMATOSCHISTUS-MINUTUS ; FISH BEHAVIOR ; SAND GOBY ; PCR ARRAY
WOS IDWOS:000305102400012
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27130
Collection水环境工程研究中心
Affiliation1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
2.Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210093, Peoples R China
3.Nanjing Univ, Sch Environm, Nanjing 210093, Peoples R China
4.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Wuhan 430064, Hubei, Peoples R China
5.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China
6.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK, Canada
7.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK, Canada
8.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
9.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Liu, Chunsheng,Yan, Wei,Zhou, Bingsheng,et al. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos[J]. AQUATIC TOXICOLOGY,2012,118:108-115.
APA Liu, Chunsheng.,Yan, Wei.,Zhou, Bingsheng.,Guo, Yongyong.,Liu, Hongling.,...&Zhang, Xiaowei.(2012).Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos.AQUATIC TOXICOLOGY,118,108-115.
MLA Liu, Chunsheng,et al."Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos".AQUATIC TOXICOLOGY 118(2012):108-115.
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