| Molecular regulation of interferon antiviral response in fish | |
| Zhang, Yi-Bing; Gui, Jian-Fang | |
| 2012-10-01 | |
| Source Publication | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| ISSN | 0145-305X |
| Volume | 38Issue:2Pages:193-202 |
| Abstract | Interferon (IFN) response is the first line of host defense against virus infection. The recent years have witnessed tremendous progress in understanding of fish IFN antiviral response. Varied number of IFN genes has been identified in different fish species but obviously, they do not show a one-to-one orthologous relationship with mammalian IFN homologs. These genes are divided into two groups with different abilities to induce downstream gene expression through binding to different receptor complexes. Consistently, some fish IFN-stimulated genes such as Mx and PKR have been confirmed for their antiviral effects. In this review, we focus on how fish cells respond to IFNs and how fish IFNs are triggered through TLR pathway and RLR pathway. We highlight the roles of IRF3 and IRF7 in activation of fish IFN response. In addition, the unique mechanisms underlying IRF3/7-dependent fish IFN response and auto-regulation of fish IFN gene expression are discussed. (C) 2012 Elsevier Ltd. All rights reserved. |
| Subtype | Review |
| Keyword | Fish Ifn Antiviral Response Jak-stat Signaling Pathway Tlr Pathway Rlr Pathway Auto-regulation Molecular Regulation |
| DOI | 10.1016/j.dci.2012.06.003 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Immunology ; Zoology |
| WOS Subject | Immunology ; Zoology |
| WOS ID | WOS:000309312700001 |
| WOS Keyword | SALMON SALMO-SALAR ; INNATE IMMUNE-RESPONSE ; TOLL-LIKE RECEPTORS ; PANCREATIC NECROSIS VIRUS ; TROUT ONCORHYNCHUS-MYKISS ; DEPENDENT PROTEIN-KINASE ; ZEBRAFISH DANIO-RERIO ; UV-INACTIVATED VIRUS ; DNA BINDING DOMAINS ; NF-KAPPA-B |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/27125 |
| Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
| Affiliation | Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Yi-Bing,Gui, Jian-Fang. Molecular regulation of interferon antiviral response in fish[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,38(2):193-202. |
| APA | Zhang, Yi-Bing,&Gui, Jian-Fang.(2012).Molecular regulation of interferon antiviral response in fish.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,38(2),193-202. |
| MLA | Zhang, Yi-Bing,et al."Molecular regulation of interferon antiviral response in fish".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38.2(2012):193-202. |
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