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Molecular regulation of interferon antiviral response in fish
Zhang, Yi-Bing; Gui, Jian-Fang
2012-10-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume38Issue:2Pages:193-202
AbstractInterferon (IFN) response is the first line of host defense against virus infection. The recent years have witnessed tremendous progress in understanding of fish IFN antiviral response. Varied number of IFN genes has been identified in different fish species but obviously, they do not show a one-to-one orthologous relationship with mammalian IFN homologs. These genes are divided into two groups with different abilities to induce downstream gene expression through binding to different receptor complexes. Consistently, some fish IFN-stimulated genes such as Mx and PKR have been confirmed for their antiviral effects. In this review, we focus on how fish cells respond to IFNs and how fish IFNs are triggered through TLR pathway and RLR pathway. We highlight the roles of IRF3 and IRF7 in activation of fish IFN response. In addition, the unique mechanisms underlying IRF3/7-dependent fish IFN response and auto-regulation of fish IFN gene expression are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
SubtypeReview
KeywordFish Ifn Antiviral Response Jak-stat Signaling Pathway Tlr Pathway Rlr Pathway Auto-regulation Molecular Regulation
DOI10.1016/j.dci.2012.06.003
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Zoology
WOS SubjectImmunology ; Zoology
WOS KeywordSALMON SALMO-SALAR ; INNATE IMMUNE-RESPONSE ; TOLL-LIKE RECEPTORS ; PANCREATIC NECROSIS VIRUS ; TROUT ONCORHYNCHUS-MYKISS ; DEPENDENT PROTEIN-KINASE ; ZEBRAFISH DANIO-RERIO ; UV-INACTIVATED VIRUS ; DNA BINDING DOMAINS ; NF-KAPPA-B
WOS IDWOS:000309312700001
Citation statistics
Cited Times:135[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27125
Collection鱼类生物学及渔业生物技术研究中心
AffiliationChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yi-Bing,Gui, Jian-Fang. Molecular regulation of interferon antiviral response in fish[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,38(2):193-202.
APA Zhang, Yi-Bing,&Gui, Jian-Fang.(2012).Molecular regulation of interferon antiviral response in fish.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,38(2),193-202.
MLA Zhang, Yi-Bing,et al."Molecular regulation of interferon antiviral response in fish".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38.2(2012):193-202.
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