IHB OpenIR  > 水生生物多样性与资源保护研究中心  > 期刊论文
Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii
Chi, Wei; Gan, Xiaoni; Xiao, Wuhan; Wang, Wen; He, Shunping
2013
Source PublicationFEBS OPEN BIO
ISSN2211-5463
Volume3Pages:479-483
AbstractHypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-alpha isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-alpha isoforms in different lineages. Only the HIF-1 alpha and HIF-2 alpha in African lungfish and amphibians were found under positive selection. HIF-1 alpha and -2 alpha were less functionally divergent in basal ray-finned fish than in teleosts, and showed conserved but different transcriptional activity towards specific target genes. (C) 2013 The Authors, Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. All rights reserved.
SubtypeArticle
KeywordHif-alpha Osteichthyes Functional Divergence Positive Selection
DOI10.1016/j.fob.2013.09.004
Indexed BySCI
Language英语
WOS IDWOS:000339569800075
WOS KeywordFUNCTIONAL DIVERGENCE ; ATMOSPHERIC OXYGEN ; HIGH-ALTITUDE ; FACTOR-1-ALPHA ; HIF-2-ALPHA ; HOMEOSTASIS ; ADAPTATION ; REGULATOR ; DOMAINS ; PATHWAY
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/27117
Collection水生生物多样性与资源保护研究中心_期刊论文
AffiliationChinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Chi, Wei,Gan, Xiaoni,Xiao, Wuhan,et al. Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii[J]. FEBS OPEN BIO,2013,3:479-483.
APA Chi, Wei,Gan, Xiaoni,Xiao, Wuhan,Wang, Wen,&He, Shunping.(2013).Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii.FEBS OPEN BIO,3,479-483.
MLA Chi, Wei,et al."Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii".FEBS OPEN BIO 3(2013):479-483.
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