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题名: Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii
作者: Chi, Wei1; Gan, Xiaoni1; Xiao, Wuhan1; Wang, Wen1; He, Shunping1
关键词: HIF-alpha ; Osteichthyes ; Functional divergence ; Positive selection
刊名: FEBS OPEN BIO
发表日期: 2013
DOI: 10.1016/j.fob.2013.09.004
卷: 3, 页:479-483
收录类别: SCI
文章类型: Article
英文摘要: Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-alpha isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-alpha isoforms in different lineages. Only the HIF-1 alpha and HIF-2 alpha in African lungfish and amphibians were found under positive selection. HIF-1 alpha and -2 alpha were less functionally divergent in basal ray-finned fish than in teleosts, and showed conserved but different transcriptional activity towards specific target genes. (C) 2013 The Authors, Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. All rights reserved.
关键词[WOS]: FUNCTIONAL DIVERGENCE ; ATMOSPHERIC OXYGEN ; HIGH-ALTITUDE ; FACTOR-1-ALPHA ; HIF-2-ALPHA ; HOMEOSTASIS ; ADAPTATION ; REGULATOR ; DOMAINS ; PATHWAY
语种: 英语
WOS记录号: WOS:000339569800075
ISSN号: 2211-5463
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/27117
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
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