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题名: Effects of microcystin-LR on gut microflora in different gut regions of mice
作者: Chen, Jing1, 2; Xie, Ping1; Lin, Juan1, 2; He, Jun1; Zeng, Cheng3; Chen, Jun1
关键词: MC-LR ; Gut microbial community ; Mice ; Intestine
刊名: JOURNAL OF TOXICOLOGICAL SCIENCES
发表日期: 2015-08-01
卷: 40, 期:4, 页:485-494
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
英文摘要: To reveal the toxicological effects of the hepatotoxic microcystin-leucine arginine (MC-LR) on gut microbial community composition in different gut regions, we conducted a subchronic exposure of BALB/c mice to MC-LR via intragastric administration. Denaturing gradient gel electrophoresis (DGGE) was employed to profile the shifts of microbes after MC-LR treatment in the jejuno-ileum, caecum and colon. DGGE profiles analysis showed that MC-LR increased the microbial species richness (number of microbial bands) in the caecum and colon as well as microbial diversity (Shannon-Wiener index) in the caecum. The cluster analysis of DGGE profiles indicated that the microbial structures in the caecum and colon shifted significantly after MC-LR treatment, while that in the jejuno-ileum did not. All the relatively decreased gut microbes belonged to Clostridia in the Firmicutes phylum, and most of them were Lachnospiraceae. The increased ones derived from a variety of microbes including species from Porphyromonadaceae and Prevotellaceae in the Bacteroidetes phylum, as well as Lachnospiraceae and Ruminococcaceae in the Firmicutes phylum, and among which, the increase of Barnesiella in Porphyromonadaceae was most remarkable. In conclusion, subchronic exposure to MC-LR could disturb the balance of gut microbes in mice, and its toxicological effects varied between the jejuno-ileum and the other two gut regions.
关键词[WOS]: SPINNING H-1-NMR SPECTROSCOPY ; FATTY LIVER-DISEASE ; IN-VITRO EVALUATION ; 16S RIBOSOMAL-RNA ; BACTERIAL DIVERSITY ; INTESTINAL MICROBIOTA ; CYANOBACTERIAL TOXINS ; MICROORGANISMS ; HEALTH ; GENES
语种: 英语
WOS记录号: WOS:000359180600007
ISSN号: 0388-1350
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/25971
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
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