| Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria) | |
| Zhao, Yang1,2,3; Liu, Weisheng1,2; Li, Qi4; Yang, Qin1,2; Chai, Wenbo3; Zeng, Mengjing1,2; Li, Renhui3; Peng, Yiyuan1,2; Peng, YY (reprint author), Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China. | |
| 2015-03-01 | |
| Source Publication | BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
 |
| ISSN | 0007-4861 |
| Volume | 94Issue:3Pages:376-381 |
| Abstract | Quinazoline derivatives have wide biological activities and therapeutic properties, implying their potential for development and application on a large scale. In the present study, 2-(4-chlorophenyl)-4-(4-methoxyphenyl) quinazoline (CMQ), was selected to examine its effect on unicellular cyanobacteria, Microcystis aeruginosa by evaluating growth, physiological and molecular responses. Growth was inhibited by CMQ, with a 96 h EC50 of 1.93 +/- A 0.19 mg L-1. The up-regulated expression of prx was shown, reflecting that oxidative stress might be a toxic factor of CMQ. At higher concentrations of CMQ, the quantum yields of Y(II) and Y(NPQ) in photosystem II decreased seriously and Y(NO) increased sharply, and psbA gene encoding for D1 protein was over-expressed. These results demonstrated that high concentrations of CMQ had different inhibitory targets associated with photosystem electron transport and with sites beyond the electron transport chain, leading to severe toxicity. |
| Subtype | Article |
| Keyword | Bioassay Cmq Growth Inhibition Microcystis Photosystem |
| Department | [Zhao, Yang ; Liu, Weisheng ; Yang, Qin ; Zeng, Mengjing ; Peng, Yiyuan] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China ; [Zhao, Yang ; Liu, Weisheng ; Yang, Qin ; Zeng, Mengjing ; Peng, Yiyuan] Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China ; [Zhao, Yang ; Chai, Wenbo ; Li, Renhui] Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China ; [Li, Qi] Wuhan Foreign Language Sch, Wuhan 430022, Peoples R China |
| DOI | 10.1007/s00128-015-1459-y |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Environmental Sciences & Ecology ; Toxicology |
| WOS Subject | Environmental Sciences ; Toxicology |
| WOS Keyword | PHOTOSYSTEM-II ; CHLOROPHYLL FLUORESCENCE ; GENE-EXPRESSION ; GROWTH ; TOXICITY ; INHIBITION ; MECHANISM ; STRESS ; AGENTS ; PCR |
| WOS ID | WOS:000349960900019 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/25770 |
| Collection | 藻类生物学及应用研究中心 |
| Corresponding Author | Peng, YY (reprint author), Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China. |
| Affiliation | 1.Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China 2.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China 4.Wuhan Foreign Language Sch, Wuhan 430022, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Yang,Liu, Weisheng,Li, Qi,et al. Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2015,94(3):376-381. |
| APA | Zhao, Yang.,Liu, Weisheng.,Li, Qi.,Yang, Qin.,Chai, Wenbo.,...&Peng, YY .(2015).Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria).BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,94(3),376-381. |
| MLA | Zhao, Yang,et al."Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)".BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 94.3(2015):376-381. |
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