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题名: Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)
作者: Zhao, Yang1, 2, 3; Liu, Weisheng1, 2; Li, Qi4; Yang, Qin1, 2; Chai, Wenbo3; Zeng, Mengjing1, 2; Li, Renhui3; Peng, Yiyuan1, 2
通讯作者: Peng, YY (reprint author), Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China.
关键词: Bioassay ; CMQ ; Growth inhibition ; Microcystis ; Photosystem
刊名: BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
发表日期: 2015-03-01
DOI: 10.1007/s00128-015-1459-y
卷: 94, 期:3, 页:376-381
收录类别: SCI
文章类型: Article
部门归属: [Zhao, Yang ; Liu, Weisheng ; Yang, Qin ; Zeng, Mengjing ; Peng, Yiyuan] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China ; [Zhao, Yang ; Liu, Weisheng ; Yang, Qin ; Zeng, Mengjing ; Peng, Yiyuan] Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China ; [Zhao, Yang ; Chai, Wenbo ; Li, Renhui] Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China ; [Li, Qi] Wuhan Foreign Language Sch, Wuhan 430022, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Toxicology
英文摘要: Quinazoline derivatives have wide biological activities and therapeutic properties, implying their potential for development and application on a large scale. In the present study, 2-(4-chlorophenyl)-4-(4-methoxyphenyl) quinazoline (CMQ), was selected to examine its effect on unicellular cyanobacteria, Microcystis aeruginosa by evaluating growth, physiological and molecular responses. Growth was inhibited by CMQ, with a 96 h EC50 of 1.93 +/- A 0.19 mg L-1. The up-regulated expression of prx was shown, reflecting that oxidative stress might be a toxic factor of CMQ. At higher concentrations of CMQ, the quantum yields of Y(II) and Y(NPQ) in photosystem II decreased seriously and Y(NO) increased sharply, and psbA gene encoding for D1 protein was over-expressed. These results demonstrated that high concentrations of CMQ had different inhibitory targets associated with photosystem electron transport and with sites beyond the electron transport chain, leading to severe toxicity.
关键词[WOS]: PHOTOSYSTEM-II ; CHLOROPHYLL FLUORESCENCE ; GENE-EXPRESSION ; GROWTH ; TOXICITY ; INHIBITION ; MECHANISM ; STRESS ; AGENTS ; PCR
语种: 英语
WOS记录号: WOS:000349960900019
ISSN号: 0007-4861
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/25770
Appears in Collections:藻类生物学及应用研究中心_期刊论文

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作者单位: 1.Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
2.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China
4.Wuhan Foreign Language Sch, Wuhan 430022, Peoples R China
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文件名: Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria).pdf
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