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Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)
Zhao, Yang1,2,3; Liu, Weisheng1,2; Li, Qi4; Yang, Qin1,2; Chai, Wenbo3; Zeng, Mengjing1,2; Li, Renhui3; Peng, Yiyuan1,2; Peng, YY (reprint author), Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China.
2015-03-01
Source PublicationBULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
ISSN0007-4861
Volume94Issue:3Pages:376-381
AbstractQuinazoline derivatives have wide biological activities and therapeutic properties, implying their potential for development and application on a large scale. In the present study, 2-(4-chlorophenyl)-4-(4-methoxyphenyl) quinazoline (CMQ), was selected to examine its effect on unicellular cyanobacteria, Microcystis aeruginosa by evaluating growth, physiological and molecular responses. Growth was inhibited by CMQ, with a 96 h EC50 of 1.93 +/- A 0.19 mg L-1. The up-regulated expression of prx was shown, reflecting that oxidative stress might be a toxic factor of CMQ. At higher concentrations of CMQ, the quantum yields of Y(II) and Y(NPQ) in photosystem II decreased seriously and Y(NO) increased sharply, and psbA gene encoding for D1 protein was over-expressed. These results demonstrated that high concentrations of CMQ had different inhibitory targets associated with photosystem electron transport and with sites beyond the electron transport chain, leading to severe toxicity.
SubtypeArticle
KeywordBioassay Cmq Growth Inhibition Microcystis Photosystem
Department[Zhao, Yang ; Liu, Weisheng ; Yang, Qin ; Zeng, Mengjing ; Peng, Yiyuan] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China ; [Zhao, Yang ; Liu, Weisheng ; Yang, Qin ; Zeng, Mengjing ; Peng, Yiyuan] Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China ; [Zhao, Yang ; Chai, Wenbo ; Li, Renhui] Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China ; [Li, Qi] Wuhan Foreign Language Sch, Wuhan 430022, Peoples R China
DOI10.1007/s00128-015-1459-y
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEnvironmental Sciences ; Toxicology
WOS KeywordPHOTOSYSTEM-II ; CHLOROPHYLL FLUORESCENCE ; GENE-EXPRESSION ; GROWTH ; TOXICITY ; INHIBITION ; MECHANISM ; STRESS ; AGENTS ; PCR
WOS IDWOS:000349960900019
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/25770
Collection藻类生物学及应用研究中心
Corresponding AuthorPeng, YY (reprint author), Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China.
Affiliation1.Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
2.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China
4.Wuhan Foreign Language Sch, Wuhan 430022, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Yang,Liu, Weisheng,Li, Qi,et al. Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2015,94(3):376-381.
APA Zhao, Yang.,Liu, Weisheng.,Li, Qi.,Yang, Qin.,Chai, Wenbo.,...&Peng, YY .(2015).Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria).BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,94(3),376-381.
MLA Zhao, Yang,et al."Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)".BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 94.3(2015):376-381.
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