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题名: Mycobacterium Tuberculosis Proteome Microarray for Global Studies of Protein Function and Immunogenicity
作者: Deng, Jiaoyu5; Bi, Lijun1, 2, 9; Zhou, Lin6; Guo, Shu-juan3, 4; Fleming, Joy1, 2; Jiang, He-wei3, 4; Zhou, Ying1, 2; Gu, Jia5; Zhong, Qiu6; Wang, Zong-xiu3, 4; Liu, Zhonghui1, 2; Deng, Rui-ping3, 4; Gao, Jing5; Chen, Tao6; Li, Wenjuan1, 2; Wang, Jing-fang3, 4; Wang, Xude5; Li, Haicheng6; Ge, Feng7; Zhu, Guofeng8; Zhang, Hai-nan3, 4; Gu, Jing5; Wu, Fan-lin3, 4; Zhang, Zhiping5; Wang, Dianbing1, 2; Hang, Haiying1, 2, 9; Li, Yang3, 4; Cheng, Li3, 4; He, Xiang3, 4; Tao, Sheng-ce3, 4; Zhang, Xian-En1, 2
通讯作者: Tao, SC (reprint author), Chinese Acad Sci, Inst Biophys, Key Lab Non Coding RNA, Natl Key Lab Biomacromol, Beijing 100101, Peoples R China.
刊名: CELL REPORTS
发表日期: 2014-12-24
DOI: 10.1016/j.celrep.2014.11.023
卷: 9, 期:6, 页:2317-2329
收录类别: SCI
文章类型: Article
部门归属: [Bi, Lijun ; Fleming, Joy ; Zhou, Ying ; Liu, Zhonghui ; Li, Wenjuan ; Wang, Dianbing ; Hang, Haiying ; Zhang, Xian-En] Chinese Acad Sci, Inst Biophys, Key Lab Non Coding RNA, Natl Key Lab Biomacromol, Beijing 100101, Peoples R China ; [Bi, Lijun ; Fleming, Joy ; Zhou, Ying ; Liu, Zhonghui ; Li, Wenjuan ; Wang, Dianbing ; Hang, Haiying ; Zhang, Xian-En] Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China ; [Guo, Shu-juan ; Jiang, He-wei ; Wang, Zong-xiu ; Deng, Rui-ping ; Wang, Jing-fang ; Zhang, Hai-nan ; Wu, Fan-lin ; Li, Yang ; Cheng, Li ; He, Xiang ; Tao, Sheng-ce] Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Minist Educ, Shanghai Ctr Syst Biomed,Key Lab Syst Biomed, Shanghai 200240, Peoples R China ; [Guo, Shu-juan ; Jiang, He-wei ; Wang, Zong-xiu ; Deng, Rui-ping ; Wang, Jing-fang ; Zhang, Hai-nan ; Wu, Fan-lin ; Li, Yang ; Cheng, Li ; He, Xiang ; Tao, Sheng-ce] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China ; [Deng, Jiaoyu ; Gu, Jia ; Gao, Jing ; Wang, Xude ; Gu, Jing ; Zhang, Zhiping] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China ; [Zhou, Lin ; Zhong, Qiu ; Chen, Tao ; Li, Haicheng] Ctr TB Control Guangdong Prov, Guangzhou 510630, Guangdong, Peoples R China ; [Ge, Feng] Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430071, Peoples R China ; [Zhu, Guofeng] Shanghai Municipal Ctr Dis Control & Prevent, Shanghai 200336, Peoples R China ; [Bi, Lijun ; Hang, Haiying] TB Healthcare Biotechnol Co Ltd, Foshan 528000, Guangdong, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
英文摘要: Poor understanding of the basic biology of Mycobacterium tuberculosis (MTB), the etiological agent of tuberculosis, hampers development of much-needed drugs, vaccines, and diagnostic tests. Better experimental tools are needed to expedite investigations of this pathogen at the systems level. Here, we present a functional MTB proteome microarray covering most of the proteome and an ORFome library. We demonstrate the broad applicability of the microarray by investigating global protein-protein interactions, small-molecule-proteinbinding, and serum biomarker discovery, identifying 59 PknG-interacting proteins, 30 bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) binding proteins, and 14 MTB proteins that together differentiate between tuberculosis (TB) patients with active disease and recovered individuals. Results suggest that the MTB rhamnose pathway is likely regulated by both the serine/threonine kinase PknG and c-di-GMP. This resource has the potential to generate a greater understanding of key biological processes in the pathogenesis of tuberculosis, possibly leading to more effective therapies for the treatment of this ancient disease.
关键词[WOS]: CYCLIC DI-GMP ; CELL-WALL ; KINASE-G ; REVEALS ; ASSAYS ; GENES ; PHOSPHORYLATION ; NORMALIZATION ; METABOLISM ; INHIBITION
语种: 英语
WOS记录号: WOS:000346852400028
ISSN号: 2211-1247
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23995
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Biophys, Key Lab Non Coding RNA, Natl Key Lab Biomacromol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
3.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Minist Educ, Shanghai Ctr Syst Biomed,Key Lab Syst Biomed, Shanghai 200240, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China
5.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
6.Ctr TB Control Guangdong Prov, Guangzhou 510630, Guangdong, Peoples R China
7.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430071, Peoples R China
8.Shanghai Municipal Ctr Dis Control & Prevent, Shanghai 200336, Peoples R China
9.TB Healthcare Biotechnol Co Ltd, Foshan 528000, Guangdong, Peoples R China
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文件名: Mycobacterium Tuberculosis Proteome Microarray for Global Studies of Protein Function and Immunogenicity.pdf
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