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The Genome of the Myxosporean Thelohanellus kitauei Shows Adaptations to Nutrient Acquisition within Its Fish Host
Yang, Yalin1; Xiong, Jie2; Zhou, Zhigang1; Huo, Fengmin1; Miao, Wei2; Ran, Chao1; Liu, Yuchun1; Zhang, Jinyong2; Feng, Jinmei2; Wang, Meng3; Wang, Min4; Wang, Lei4; Yao, Bin1; Yao, B (reprint author), Chinese Acad Agr Sci, Feed Res Inst, Minist Agr, Key Lab Feed Biotechnol, Beijing 100193, Peoples R China.
2014-12-01
Source PublicationGENOME BIOLOGY AND EVOLUTION
ISSN1759-6653
Volume6Issue:12Pages:3182-3198
AbstractMembers of Myxozoa, a parasitic metazoan taxon, have considerable detrimental effects on fish hosts and also have been associated with human food-borne illness. Little is known about their biology and metabolism. Analysis of the genome of Thelohanellus kitauei and comparative analysis with genomes of its two free-living cnidarian relatives revealed that T. kitauei has adapted to parasitism, as indicated by the streamlined metabolic repertoire and the tendency toward anabolism rather than catabolism. Thelohanellus kitauei mainly secretes proteases and protease inhibitors for nutrient digestion (parasite invasion), and depends on endocytosis (mainly low-density lipoprotein receptors-mediated type) and secondary carriers for nutrient absorption. Absence of both classic and complementary anaerobic pathways and gluconeogenesis, the lack of de novo synthesis and reduced activity in hydrolysis of fatty acids, amino acids, and nucleotides indicated that T. kitauei in this vertebrate host-parasite system has adapted to inhabit a physiological environment extremely rich in both oxygen and nutrients (especially glucose), which is consistent with its preferred parasitic site, that is, the host gut submucosa. Taking advantage of the genomic and transcriptomic information, 23 potential nutrition-related T. kitauei-specific chemotherapeutic targets were identified. This first genome sequence of a myxozoan will facilitate development of potential therapeutics for efficient control of myxozoan parasites and ultimately prevent myxozoan-induced fish-borne illnesses in humans.
SubtypeArticle
KeywordMyxozoa Genome And Transcriptome Nutrient Deprivation Food-borne Illness
Department[Yang, Yalin ; Zhou, Zhigang ; Huo, Fengmin ; Ran, Chao ; Liu, Yuchun ; Yao, Bin] Chinese Acad Agr Sci, Feed Res Inst, Minist Agr, Key Lab Feed Biotechnol, Beijing 100193, Peoples R China ; [Xiong, Jie ; Miao, Wei ; Zhang, Jinyong ; Feng, Jinmei] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China ; [Wang, Meng] Tianjin Biochip Corp, Tianjin, Peoples R China ; [Wang, Min ; Wang, Lei] Nankai Univ, TEDA Sch Biol Sci & Biotechnol, Tianjin 300071, Peoples R China
DOI10.1093/gbe/evu247
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEvolutionary Biology ; Genetics & Heredity
WOS SubjectEvolutionary Biology ; Genetics & Heredity
WOS IDWOS:000347000800005
WOS KeywordGLUTATHIONE-S-TRANSFERASE ; MYXOBOLUS SP INFECTION ; PLASMODIUM-FALCIPARUM ; THERAPEUTIC TARGET ; ENTAMOEBA-HISTOLYTICA ; DRUG TARGET ; INNOVATIVE TREATMENTS ; MOLECULAR-BIOLOGY ; SIGNAL PEPTIDES ; GIARDIA-LAMBLIA
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23994
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorYao, B (reprint author), Chinese Acad Agr Sci, Feed Res Inst, Minist Agr, Key Lab Feed Biotechnol, Beijing 100193, Peoples R China.
Affiliation1.Chinese Acad Agr Sci, Feed Res Inst, Minist Agr, Key Lab Feed Biotechnol, Beijing 100193, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China
3.Tianjin Biochip Corp, Tianjin, Peoples R China
4.Nankai Univ, TEDA Sch Biol Sci & Biotechnol, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yalin,Xiong, Jie,Zhou, Zhigang,et al. The Genome of the Myxosporean Thelohanellus kitauei Shows Adaptations to Nutrient Acquisition within Its Fish Host[J]. GENOME BIOLOGY AND EVOLUTION,2014,6(12):3182-3198.
APA Yang, Yalin.,Xiong, Jie.,Zhou, Zhigang.,Huo, Fengmin.,Miao, Wei.,...&Yao, B .(2014).The Genome of the Myxosporean Thelohanellus kitauei Shows Adaptations to Nutrient Acquisition within Its Fish Host.GENOME BIOLOGY AND EVOLUTION,6(12),3182-3198.
MLA Yang, Yalin,et al."The Genome of the Myxosporean Thelohanellus kitauei Shows Adaptations to Nutrient Acquisition within Its Fish Host".GENOME BIOLOGY AND EVOLUTION 6.12(2014):3182-3198.
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