The hypoxia signaling pathway and hypoxic adaptation in fishes
Xiao Wuhan; Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China.
2015-02-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
Volume58Issue:2Pages:148-155
AbstractThe hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway present in animals ranging from Caenorhabditis elegans to mammals. The pathway is crucial for oxygen homeostasis maintenance. Hypoxia-inducible factors (HIF-1 alpha and HIF-2 alpha) are master regulators in the hypoxia signaling pathway. Oxygen concentrations vary a lot in the aquatic environment. To deal with this, fishes have adapted and developed varying strategies for living in hypoxic conditions. Investigations into the strategies and mechanisms of hypoxia adaptation in fishes will allow us to understand fish speciation and breed hypoxia-tolerant fish species/strains. This review summarizes the process of the hypoxia signaling pathway and its regulation, as well as the mechanism of hypoxia adaptation in fishes.
SubtypeReview
KeywordHypoxia Hypoxia-inducible Factors Phds Pvhl Fih Fish
DepartmentChinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
DOI10.1007/s11427-015-4801-z
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS KeywordGOLDFISH CARASSIUS-AURATUS ; BASS DICENTRARCHUS-LABRAX ; FACTOR-ALPHA SUBUNITS ; INDUCIBLE-FACTOR ; GENE-EXPRESSION ; CRUCIAN CARP ; FACTOR HIF-1-ALPHA ; OXIDATIVE STRESS ; HIF-ALPHA ; TRANSCRIPTIONAL REGULATION
WOS IDWOS:000349407000004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23989
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Corresponding AuthorXiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China.
AffiliationChinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Xiao Wuhan,Xiao, WH . The hypoxia signaling pathway and hypoxic adaptation in fishes[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(2):148-155.
APA Xiao Wuhan,&Xiao, WH .(2015).The hypoxia signaling pathway and hypoxic adaptation in fishes.SCIENCE CHINA-LIFE SCIENCES,58(2),148-155.
MLA Xiao Wuhan,et al."The hypoxia signaling pathway and hypoxic adaptation in fishes".SCIENCE CHINA-LIFE SCIENCES 58.2(2015):148-155.
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