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题名: The hypoxia signaling pathway and hypoxic adaptation in fishes
作者: Xiao Wuhan
通讯作者: Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China.
关键词: hypoxia ; hypoxia-inducible factors ; PHDs ; pVHL ; FIH ; fish
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2015-02-01
DOI: 10.1007/s11427-015-4801-z
卷: 58, 期:2, 页:148-155
收录类别: SCI
文章类型: Review
部门归属: Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
英文摘要: The hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway present in animals ranging from Caenorhabditis elegans to mammals. The pathway is crucial for oxygen homeostasis maintenance. Hypoxia-inducible factors (HIF-1 alpha and HIF-2 alpha) are master regulators in the hypoxia signaling pathway. Oxygen concentrations vary a lot in the aquatic environment. To deal with this, fishes have adapted and developed varying strategies for living in hypoxic conditions. Investigations into the strategies and mechanisms of hypoxia adaptation in fishes will allow us to understand fish speciation and breed hypoxia-tolerant fish species/strains. This review summarizes the process of the hypoxia signaling pathway and its regulation, as well as the mechanism of hypoxia adaptation in fishes.
关键词[WOS]: GOLDFISH CARASSIUS-AURATUS ; BASS DICENTRARCHUS-LABRAX ; FACTOR-ALPHA SUBUNITS ; INDUCIBLE-FACTOR ; GENE-EXPRESSION ; CRUCIAN CARP ; FACTOR HIF-1-ALPHA ; OXIDATIVE STRESS ; HIF-ALPHA ; TRANSCRIPTIONAL REGULATION
语种: 英语
WOS记录号: WOS:000349407000004
ISSN号: 1674-7305
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23989
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
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