| The hypoxia signaling pathway and hypoxic adaptation in fishes | |
| Xiao Wuhan; Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China. | |
| 2015-02-01 | |
| Source Publication | SCIENCE CHINA-LIFE SCIENCES
 |
| ISSN | 1674-7305 |
| Volume | 58Issue:2Pages:148-155 |
| Abstract | The hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway present in animals ranging from Caenorhabditis elegans to mammals. The pathway is crucial for oxygen homeostasis maintenance. Hypoxia-inducible factors (HIF-1 alpha and HIF-2 alpha) are master regulators in the hypoxia signaling pathway. Oxygen concentrations vary a lot in the aquatic environment. To deal with this, fishes have adapted and developed varying strategies for living in hypoxic conditions. Investigations into the strategies and mechanisms of hypoxia adaptation in fishes will allow us to understand fish speciation and breed hypoxia-tolerant fish species/strains. This review summarizes the process of the hypoxia signaling pathway and its regulation, as well as the mechanism of hypoxia adaptation in fishes. |
| Subtype | Review |
| Keyword | Hypoxia Hypoxia-inducible Factors Phds Pvhl Fih Fish |
| Department | Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China |
| DOI | 10.1007/s11427-015-4801-z |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics |
| WOS Subject | Biology |
| WOS ID | WOS:000349407000004 |
| WOS Keyword | GOLDFISH CARASSIUS-AURATUS ; BASS DICENTRARCHUS-LABRAX ; FACTOR-ALPHA SUBUNITS ; INDUCIBLE-FACTOR ; GENE-EXPRESSION ; CRUCIAN CARP ; FACTOR HIF-1-ALPHA ; OXIDATIVE STRESS ; HIF-ALPHA ; TRANSCRIPTIONAL REGULATION |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/23989 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China. |
| Affiliation | Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China |
| Recommended Citation GB/T 7714 | Xiao Wuhan,Xiao, WH . The hypoxia signaling pathway and hypoxic adaptation in fishes[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(2):148-155. |
| APA | Xiao Wuhan,&Xiao, WH .(2015).The hypoxia signaling pathway and hypoxic adaptation in fishes.SCIENCE CHINA-LIFE SCIENCES,58(2),148-155. |
| MLA | Xiao Wuhan,et al."The hypoxia signaling pathway and hypoxic adaptation in fishes".SCIENCE CHINA-LIFE SCIENCES 58.2(2015):148-155. |
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| The hypoxia signalin（508KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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