| Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish | |
| Yang, Xiaojie1,2; Gu, Qilin1,2; Lin, Li3; Li, Shaoyang3; Zhong, Shan3; Li, Qing1; Cui, Zongbin1; Li, Q (reprint author), Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China. | |
| 2015-04-01 | |
| Source Publication | MOLECULAR AND CELLULAR BIOLOGY
 |
| ISSN | 0270-7306 |
| Volume | 35Issue:7Pages:1110-1124 |
| Abstract | Nucleoporin p62 (Nup62) localizes in the central channel of nuclear pore complexes (NPCs) and regulates nuclear pore permeability and nucleocytoplasmic transport. However, the developmental roles of Nup62 in vertebrates remain largely unclear. Zebrafish Nup62-like protein (Nup62l) is a homolog of mammalian Nup62. The nup62l gene is maternally expressed, but its transcripts are ubiquitously distributed during early embryogenesis and enriched in the head, pharynx, and intestine of developing embryos. Activation of the Wnt/beta-catenin pathway positively modulates nup62l transcription, while Bmp signaling acts downstream of Wnt/b-catenin signaling to negatively regulate nup62l expression. Overexpression of nup62l dorsalized embryos and enhanced gastrula convergence and extension (CE) movements. In contrast, knockdown of Nup62l led to ventralized embryos, an impediment to CE movements, and defects in specification of midline organ progenitors. Mechanistically, Nup62l acts as an activator of Wnt/beta-catenin signaling through interaction with and facilitation of nuclear import of beta-catenin-1/2 in zebrafish. Thus, Nup62l regulates dorsoventral patterning, gastrula CE movements, and proper specification of midline organ precursors through mediating the nuclear import of beta-catenins in zebrafish. |
| Subtype | Article |
| Department | [Yang, Xiaojie ; Gu, Qilin ; Li, Qing ; Cui, Zongbin] Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China ; [Yang, Xiaojie ; Gu, Qilin] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Lin, Li ; Li, Shaoyang ; Zhong, Shan] Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China |
| DOI | 10.1128/MCB.01181-14 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology ; Cell Biology |
| WOS Subject | Biochemistry & Molecular Biology ; Cell Biology |
| WOS ID | WOS:000351739200004 |
| WOS Keyword | BONE MORPHOGENETIC PROTEINS ; PORE COMPLEX ; XENOPUS EMBRYOS ; NUCLEOCYTOPLASMIC TRANSPORT ; EXTENSION MOVEMENTS ; COLORECTAL-CANCER ; CELL MOVEMENTS ; AXIS FORMATION ; MESSENGER-RNA ; P62 COMPLEX |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/23983 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Li, Q (reprint author), Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China. |
| Affiliation | 1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Xiaojie,Gu, Qilin,Lin, Li,et al. Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish[J]. MOLECULAR AND CELLULAR BIOLOGY,2015,35(7):1110-1124. |
| APA | Yang, Xiaojie.,Gu, Qilin.,Lin, Li.,Li, Shaoyang.,Zhong, Shan.,...&Li, Q .(2015).Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish.MOLECULAR AND CELLULAR BIOLOGY,35(7),1110-1124. |
| MLA | Yang, Xiaojie,et al."Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish".MOLECULAR AND CELLULAR BIOLOGY 35.7(2015):1110-1124. |
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| Nucleoporin 62-Like （3486KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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