Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish
Yang, Xiaojie1,2; Gu, Qilin1,2; Lin, Li3; Li, Shaoyang3; Zhong, Shan3; Li, Qing1; Cui, Zongbin1; Li, Q (reprint author), Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China.
2015-04-01
Source PublicationMOLECULAR AND CELLULAR BIOLOGY
ISSN0270-7306
Volume35Issue:7Pages:1110-1124
AbstractNucleoporin p62 (Nup62) localizes in the central channel of nuclear pore complexes (NPCs) and regulates nuclear pore permeability and nucleocytoplasmic transport. However, the developmental roles of Nup62 in vertebrates remain largely unclear. Zebrafish Nup62-like protein (Nup62l) is a homolog of mammalian Nup62. The nup62l gene is maternally expressed, but its transcripts are ubiquitously distributed during early embryogenesis and enriched in the head, pharynx, and intestine of developing embryos. Activation of the Wnt/beta-catenin pathway positively modulates nup62l transcription, while Bmp signaling acts downstream of Wnt/b-catenin signaling to negatively regulate nup62l expression. Overexpression of nup62l dorsalized embryos and enhanced gastrula convergence and extension (CE) movements. In contrast, knockdown of Nup62l led to ventralized embryos, an impediment to CE movements, and defects in specification of midline organ progenitors. Mechanistically, Nup62l acts as an activator of Wnt/beta-catenin signaling through interaction with and facilitation of nuclear import of beta-catenin-1/2 in zebrafish. Thus, Nup62l regulates dorsoventral patterning, gastrula CE movements, and proper specification of midline organ precursors through mediating the nuclear import of beta-catenins in zebrafish.
SubtypeArticle
Department[Yang, Xiaojie ; Gu, Qilin ; Li, Qing ; Cui, Zongbin] Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China ; [Yang, Xiaojie ; Gu, Qilin] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Lin, Li ; Li, Shaoyang ; Zhong, Shan] Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China
DOI10.1128/MCB.01181-14
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS KeywordBONE MORPHOGENETIC PROTEINS ; PORE COMPLEX ; XENOPUS EMBRYOS ; NUCLEOCYTOPLASMIC TRANSPORT ; EXTENSION MOVEMENTS ; COLORECTAL-CANCER ; CELL MOVEMENTS ; AXIS FORMATION ; MESSENGER-RNA ; P62 COMPLEX
WOS IDWOS:000351739200004
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23983
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Corresponding AuthorLi, Q (reprint author), Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China.
Affiliation1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xiaojie,Gu, Qilin,Lin, Li,et al. Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish[J]. MOLECULAR AND CELLULAR BIOLOGY,2015,35(7):1110-1124.
APA Yang, Xiaojie.,Gu, Qilin.,Lin, Li.,Li, Shaoyang.,Zhong, Shan.,...&Li, Q .(2015).Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish.MOLECULAR AND CELLULAR BIOLOGY,35(7),1110-1124.
MLA Yang, Xiaojie,et al."Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish".MOLECULAR AND CELLULAR BIOLOGY 35.7(2015):1110-1124.
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