中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
题名: Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish
作者: Yang, Xiaojie1, 2; Gu, Qilin1, 2; Lin, Li3; Li, Shaoyang3; Zhong, Shan3; Li, Qing1; Cui, Zongbin1
通讯作者: Li, Q (reprint author), Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China.
刊名: MOLECULAR AND CELLULAR BIOLOGY
发表日期: 2015-04-01
DOI: 10.1128/MCB.01181-14
卷: 35, 期:7, 页:1110-1124
收录类别: SCI
文章类型: Article
部门归属: [Yang, Xiaojie ; Gu, Qilin ; Li, Qing ; Cui, Zongbin] Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China ; [Yang, Xiaojie ; Gu, Qilin] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Lin, Li ; Li, Shaoyang ; Zhong, Shan] Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
英文摘要: Nucleoporin p62 (Nup62) localizes in the central channel of nuclear pore complexes (NPCs) and regulates nuclear pore permeability and nucleocytoplasmic transport. However, the developmental roles of Nup62 in vertebrates remain largely unclear. Zebrafish Nup62-like protein (Nup62l) is a homolog of mammalian Nup62. The nup62l gene is maternally expressed, but its transcripts are ubiquitously distributed during early embryogenesis and enriched in the head, pharynx, and intestine of developing embryos. Activation of the Wnt/beta-catenin pathway positively modulates nup62l transcription, while Bmp signaling acts downstream of Wnt/b-catenin signaling to negatively regulate nup62l expression. Overexpression of nup62l dorsalized embryos and enhanced gastrula convergence and extension (CE) movements. In contrast, knockdown of Nup62l led to ventralized embryos, an impediment to CE movements, and defects in specification of midline organ progenitors. Mechanistically, Nup62l acts as an activator of Wnt/beta-catenin signaling through interaction with and facilitation of nuclear import of beta-catenin-1/2 in zebrafish. Thus, Nup62l regulates dorsoventral patterning, gastrula CE movements, and proper specification of midline organ precursors through mediating the nuclear import of beta-catenins in zebrafish.
关键词[WOS]: BONE MORPHOGENETIC PROTEINS ; PORE COMPLEX ; XENOPUS EMBRYOS ; NUCLEOCYTOPLASMIC TRANSPORT ; EXTENSION MOVEMENTS ; COLORECTAL-CANCER ; CELL MOVEMENTS ; AXIS FORMATION ; MESSENGER-RNA ; P62 COMPLEX
语种: 英语
WOS记录号: WOS:000351739200004
ISSN号: 0270-7306
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23983
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish.pdf(3486KB)----开放获取View Download

作者单位: 1.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Xiaojie]'s Articles
[Gu, Qilin]'s Articles
[Lin, Li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Xiaojie]‘s Articles
[Gu, Qilin]‘s Articles
[Lin, Li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Nucleoporin 62-Like Protein Activates Canonical Wnt Signaling through Facilitating the Nuclear Import of beta-Catenin in Zebrafish.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院水生生物研究所 - Feedback
Powered by CSpace