| Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish | |
| Cheng, Xiaoxia1,2; Chen, Xiaowen1; Li, Dongliang1,2; Jin, Xia1; He, Jiangyan1; Yin, Zhan1; Yin, Z (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China. | |
| 2015-04-01 | |
| Source Publication | GENERAL AND COMPARATIVE ENDOCRINOLOGY
 |
| ISSN | 0016-6480 |
| Volume | 214Pages:87-94 |
| Abstract | The Metronidazole (MTZ), a widely used antibiotic for treating variations of infections, recently is applied in a powerful tool for specifically ablating cells or tissues when combined with E. coil nitroreductase (NTR). Although some undesired biological effects on eukaryote cells have been reported previously, the toxicological mechanism of MTZ has not been uncovered yet. In current study, we found that MTZ can induce proopiomelanocortin a (pomca) expression in zebrafish larvae. The effect of MTZ is in stage-sensitive and dose-dependent manner. A pro-proliferation activity of MTZ on pomca-expressing cells in the pituitary at larval stage was also observed. Furthermore, up-regulated levels of prolactin (prl) and glycoprotein hormone subunit alpha (gsu alpha) were also observed after the MTZ treatment. Therefore, utilizing our zebrafish as in vivo model, we concluded that MTZ can interfere the endocrine signals in the pituitary hormone genes expression. Our current results raised the cautions to the intensively application of MTZ in clinical practices and biomedical researches. (C) 2014 Elsevier Inc. All rights reserved. |
| Subtype | Article |
| Keyword | Pomca Expression Metronidazole Zebrafish Endocrine Interference |
| Department | [Cheng, Xiaoxia ; Chen, Xiaowen ; Li, Dongliang ; Jin, Xia ; He, Jiangyan ; Yin, Zhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China ; [Cheng, Xiaoxia ; Li, Dongliang] Univ Chinese Acad Sci, Beijing, Peoples R China |
| DOI | 10.1016/j.ygcen.2014.05.029 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Endocrinology & Metabolism |
| WOS Subject | Endocrinology & Metabolism |
| WOS ID | WOS:000353844300012 |
| WOS Keyword | TRANSGENIC ZEBRAFISH ; BACTEROIDES INFECTIONS ; DISRUPTING CHEMICALS ; TARGETED ABLATION ; CELL ABLATION ; NITROREDUCTASE ; MODEL ; REGENERATION ; PREVENTION ; DEATH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/23980 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Yin, Z (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China. |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Cheng, Xiaoxia,Chen, Xiaowen,Li, Dongliang,et al. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2015,214:87-94. |
| APA | Cheng, Xiaoxia.,Chen, Xiaowen.,Li, Dongliang.,Jin, Xia.,He, Jiangyan.,...&Yin, Z .(2015).Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish.GENERAL AND COMPARATIVE ENDOCRINOLOGY,214,87-94. |
| MLA | Cheng, Xiaoxia,et al."Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish".GENERAL AND COMPARATIVE ENDOCRINOLOGY 214(2015):87-94. |
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