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题名: Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish
作者: Cheng, Xiaoxia1, 2; Chen, Xiaowen1; Li, Dongliang1, 2; Jin, Xia1; He, Jiangyan1; Yin, Zhan1
通讯作者: Yin, Z (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China.
关键词: Pomca expression ; Metronidazole ; Zebrafish ; Endocrine interference
刊名: GENERAL AND COMPARATIVE ENDOCRINOLOGY
发表日期: 2015-04-01
DOI: 10.1016/j.ygcen.2014.05.029
卷: 214, 页:87-94
收录类别: SCI
文章类型: Article
部门归属: [Cheng, Xiaoxia ; Chen, Xiaowen ; Li, Dongliang ; Jin, Xia ; He, Jiangyan ; Yin, Zhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China ; [Cheng, Xiaoxia ; Li, Dongliang] Univ Chinese Acad Sci, Beijing, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: The Metronidazole (MTZ), a widely used antibiotic for treating variations of infections, recently is applied in a powerful tool for specifically ablating cells or tissues when combined with E. coil nitroreductase (NTR). Although some undesired biological effects on eukaryote cells have been reported previously, the toxicological mechanism of MTZ has not been uncovered yet. In current study, we found that MTZ can induce proopiomelanocortin a (pomca) expression in zebrafish larvae. The effect of MTZ is in stage-sensitive and dose-dependent manner. A pro-proliferation activity of MTZ on pomca-expressing cells in the pituitary at larval stage was also observed. Furthermore, up-regulated levels of prolactin (prl) and glycoprotein hormone subunit alpha (gsu alpha) were also observed after the MTZ treatment. Therefore, utilizing our zebrafish as in vivo model, we concluded that MTZ can interfere the endocrine signals in the pituitary hormone genes expression. Our current results raised the cautions to the intensively application of MTZ in clinical practices and biomedical researches. (C) 2014 Elsevier Inc. All rights reserved.
关键词[WOS]: TRANSGENIC ZEBRAFISH ; BACTEROIDES INFECTIONS ; DISRUPTING CHEMICALS ; TARGETED ABLATION ; CELL ABLATION ; NITROREDUCTASE ; MODEL ; REGENERATION ; PREVENTION ; DEATH
语种: 英语
WOS记录号: WOS:000353844300012
ISSN号: 0016-6480
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23980
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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