Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish
Cheng, Xiaoxia1,2; Chen, Xiaowen1; Li, Dongliang1,2; Jin, Xia1; He, Jiangyan1; Yin, Zhan1; Yin, Z (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China.
2015-04-01
Source PublicationGENERAL AND COMPARATIVE ENDOCRINOLOGY
ISSN0016-6480
Volume214Pages:87-94
AbstractThe Metronidazole (MTZ), a widely used antibiotic for treating variations of infections, recently is applied in a powerful tool for specifically ablating cells or tissues when combined with E. coil nitroreductase (NTR). Although some undesired biological effects on eukaryote cells have been reported previously, the toxicological mechanism of MTZ has not been uncovered yet. In current study, we found that MTZ can induce proopiomelanocortin a (pomca) expression in zebrafish larvae. The effect of MTZ is in stage-sensitive and dose-dependent manner. A pro-proliferation activity of MTZ on pomca-expressing cells in the pituitary at larval stage was also observed. Furthermore, up-regulated levels of prolactin (prl) and glycoprotein hormone subunit alpha (gsu alpha) were also observed after the MTZ treatment. Therefore, utilizing our zebrafish as in vivo model, we concluded that MTZ can interfere the endocrine signals in the pituitary hormone genes expression. Our current results raised the cautions to the intensively application of MTZ in clinical practices and biomedical researches. (C) 2014 Elsevier Inc. All rights reserved.
SubtypeArticle
KeywordPomca Expression Metronidazole Zebrafish Endocrine Interference
Department[Cheng, Xiaoxia ; Chen, Xiaowen ; Li, Dongliang ; Jin, Xia ; He, Jiangyan ; Yin, Zhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China ; [Cheng, Xiaoxia ; Li, Dongliang] Univ Chinese Acad Sci, Beijing, Peoples R China
DOI10.1016/j.ygcen.2014.05.029
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS KeywordTRANSGENIC ZEBRAFISH ; BACTEROIDES INFECTIONS ; DISRUPTING CHEMICALS ; TARGETED ABLATION ; CELL ABLATION ; NITROREDUCTASE ; MODEL ; REGENERATION ; PREVENTION ; DEATH
WOS IDWOS:000353844300012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23980
Collection藻类生物学及应用研究中心_水生生物分子与细胞生物学研究中心
Corresponding AuthorYin, Z (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Xiaoxia,Chen, Xiaowen,Li, Dongliang,et al. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2015,214:87-94.
APA Cheng, Xiaoxia.,Chen, Xiaowen.,Li, Dongliang.,Jin, Xia.,He, Jiangyan.,...&Yin, Z .(2015).Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish.GENERAL AND COMPARATIVE ENDOCRINOLOGY,214,87-94.
MLA Cheng, Xiaoxia,et al."Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish".GENERAL AND COMPARATIVE ENDOCRINOLOGY 214(2015):87-94.
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