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题名: Dietary leucine regulates the intestinal immune status, immune-related signalling molecules and tight junction transcript abundance in grass carp (Ctenopharyngodon idella)
作者: Jiang, Wei-Dan1, 2, 3; Deng, Yu-Ping1; Liu, Yang1, 2, 3; Qu, Biao1; Jiang, Jun1, 2, 3; Kuang, Sheng-Yao4; Tang, Ling4; Tang, Wu-Neng4; Wu, Pei1; Zhang, Yong-An5; Zhou, Xiao-Qiu1, 2, 3; Feng, Lin1, 2, 3
通讯作者: Zhou, XQ (reprint author), Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China.
关键词: Leucine ; Intestinal immune ; Tight junction ; Nuclear factor kappa B p65 ; Target of rapamycin
刊名: AQUACULTURE
发表日期: 2015-07-01
DOI: 10.1016/j.aquaculture.2015.04.005
卷: 444, 页:134-142
收录类别: SCI
文章类型: Article
部门归属: [Jiang, Wei-Dan ; Deng, Yu-Ping ; Liu, Yang ; Qu, Biao ; Jiang, Jun ; Wu, Pei ; Zhou, Xiao-Qiu ; Feng, Lin] Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China ; [Jiang, Wei-Dan ; Liu, Yang ; Jiang, Jun ; Zhou, Xiao-Qiu ; Feng, Lin] Sichuan Agr Univ, Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China ; [Jiang, Wei-Dan ; Liu, Yang ; Jiang, Jun ; Zhou, Xiao-Qiu ; Feng, Lin] Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr China, Minist Educ, Chengdu 611130, Sichuan, Peoples R China ; [Kuang, Sheng-Yao ; Tang, Ling ; Tang, Wu-Neng] Sichuan Acad Anim Sci, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China ; [Zhang, Yong-An] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Fisheries ; Marine & Freshwater Biology
研究领域[WOS]: Fisheries ; Marine & Freshwater Biology
英文摘要: The role of leucine (Leu) in the regulation of the intestinal immune status, immune-related signalling molecules and tight junction (TJ) protein transcript abundance in the intestine of grass carp ( Ctenopharyngodon idella) was investigated. Six iso-nitrogenous diets that contained graded levels of Leu (7.1-17.1 g Leu kg(-1) diets) were fed to the fish for 8 weeks. Compared with the control group, appropriate Leu supplementation increased (P < 0.05) the following: (1) the lysozyme activity, acid phosphatase activity and complement component 3 (C3) content in all intestinal segments; (2) the mRNA levels of interleukin 10, inhibitor factor kappa B alpha (I kappa Ba) and target of rapamycin ( TOR) in the mid and distal intestine as well as transforming growth factor beta 1 in all intestinal segments; and ( 3) the transcript levels for claudin b, claudin 3, claudin 15, occludin and zonula occludens-1 (ZO-1) in the intestine of young grass carp. At the same time, appropriate Leu supplementation down-regulated the mRNA levels of tumour necrosis factor a, interleukin 8 and nuclear factor kappa B p65 ( NF-kappa B p65) in the mid and distal intestine of young grass carp (P < 0.05). Interestingly, the transcript levels for claudin c and claudin 12 showed no significant differences among the groups in the intestine of young grass carp. In conclusion, the positive effect of Leu on intestinal health is associated with the improvement of the intestinal immune status and the regulation of immune-related signalling molecules and tight junction transcripts of fish. (C) 2015 Elsevier B.V. All rights reserved.
关键词[WOS]: NF-KAPPA-B ; CHAIN AMINO-ACIDS ; GENE-EXPRESSION ; TNF-ALPHA ; ANTIOXIDANT STATUS ; GROWTH-PERFORMANCE ; DISEASE RESISTANCE ; BARRIER FUNCTION ; INNATE IMMUNITY ; JUVENILE JIAN
语种: 英语
WOS记录号: WOS:000353644800018
ISSN号: 0044-8486
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23977
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China
2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China
3.Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr China, Minist Educ, Chengdu 611130, Sichuan, Peoples R China
4.Sichuan Acad Anim Sci, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
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