| FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity | |
| Mei, Zhichao1; Zhang, Dawei1; Hu, Bo1; Wang, Jing1; Shen, Xian3; Xiao, Wuhan1,2; Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China. | |
| 2015-06-26 | |
| Source Publication | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| ISSN | 0021-9258 |
| Volume | 290Issue:26Pages:16202-16214 |
| Abstract | Background: FBXO32 is an E3 ubiquitin ligase that plays important roles in tumorigenesis and muscle atrophy. Results: c-Myc was found to be a target of FBXO32 for proteasomal degradation. Conclusion: FBXO32 targets Lys-326 of c-Myc to form polyubiquitin chains, resulting in inhibition of cell proliferation. Significance: FBXO32 may mediate c-Myc proteasomal degradation. |
| Subtype | Article |
| Keyword | Cell Proliferation Muscle Atrophy Myc (c-Myc) Oncogene Ubiquitylation (Ubiquitination) Fbxo32 Proteasomal Degradation |
| Department | [Mei, Zhichao ; Zhang, Dawei ; Hu, Bo ; Wang, Jing ; Xiao, Wuhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China ; [Xiao, Wuhan] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Shen, Xian] Wenzhou Med Univ, Hosp 1, Wenzhou 325000, Peoples R China |
| DOI | 10.1074/jbc.M115.645978 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| WOS ID | WOS:000356930100024 |
| WOS Keyword | SKELETAL-MUSCLE ATROPHY ; FOXO TRANSCRIPTION FACTORS ; UBIQUITIN LIGASE ; DEPENDENT DEGRADATION ; PROTEIN EXPRESSION ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; MESSENGER-RNA ; PHOSPHORYLATION ; IDENTIFICATION |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/23968 |
| Collection | 水生生物分子与细胞生物学研究中心_期刊论文 |
| Corresponding Author | Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China. |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Wenzhou Med Univ, Hosp 1, Wenzhou 325000, Peoples R China |
| Recommended Citation GB/T 7714 | Mei, Zhichao,Zhang, Dawei,Hu, Bo,et al. FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(26):16202-16214. |
| APA | Mei, Zhichao.,Zhang, Dawei.,Hu, Bo.,Wang, Jing.,Shen, Xian.,...&Xiao, WH .(2015).FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity.JOURNAL OF BIOLOGICAL CHEMISTRY,290(26),16202-16214. |
| MLA | Mei, Zhichao,et al."FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity".JOURNAL OF BIOLOGICAL CHEMISTRY 290.26(2015):16202-16214. |
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| FBXO32 Targets c-Myc（3926KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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