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FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity
Mei, Zhichao1; Zhang, Dawei1; Hu, Bo1; Wang, Jing1; Shen, Xian3; Xiao, Wuhan1,2; Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
2015-06-26
Source PublicationJOURNAL OF BIOLOGICAL CHEMISTRY
ISSN0021-9258
Volume290Issue:26Pages:16202-16214
AbstractBackground: FBXO32 is an E3 ubiquitin ligase that plays important roles in tumorigenesis and muscle atrophy. Results: c-Myc was found to be a target of FBXO32 for proteasomal degradation. Conclusion: FBXO32 targets Lys-326 of c-Myc to form polyubiquitin chains, resulting in inhibition of cell proliferation. Significance: FBXO32 may mediate c-Myc proteasomal degradation.
SubtypeArticle
KeywordCell Proliferation Muscle Atrophy Myc (c-Myc) Oncogene Ubiquitylation (Ubiquitination) Fbxo32 Proteasomal Degradation
Department[Mei, Zhichao ; Zhang, Dawei ; Hu, Bo ; Wang, Jing ; Xiao, Wuhan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China ; [Xiao, Wuhan] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Shen, Xian] Wenzhou Med Univ, Hosp 1, Wenzhou 325000, Peoples R China
DOI10.1074/jbc.M115.645978
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000356930100024
WOS KeywordSKELETAL-MUSCLE ATROPHY ; FOXO TRANSCRIPTION FACTORS ; UBIQUITIN LIGASE ; DEPENDENT DEGRADATION ; PROTEIN EXPRESSION ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; MESSENGER-RNA ; PHOSPHORYLATION ; IDENTIFICATION
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23968
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorXiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Wenzhou Med Univ, Hosp 1, Wenzhou 325000, Peoples R China
Recommended Citation
GB/T 7714
Mei, Zhichao,Zhang, Dawei,Hu, Bo,et al. FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(26):16202-16214.
APA Mei, Zhichao.,Zhang, Dawei.,Hu, Bo.,Wang, Jing.,Shen, Xian.,...&Xiao, WH .(2015).FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity.JOURNAL OF BIOLOGICAL CHEMISTRY,290(26),16202-16214.
MLA Mei, Zhichao,et al."FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity".JOURNAL OF BIOLOGICAL CHEMISTRY 290.26(2015):16202-16214.
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