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题名: Regulation pattern of fish irf4 (the gene encoding IFN regulatory factor 4) by STAT6, c-Rel and IRF4
作者: Li, Shun1; Guo, Xia1, 2; Lu, Long-Feng1, 2; Lu, Xiao-Bing1, 2; Wu, Nan1; Zhang, Yong-An1
通讯作者: Zhang, YA (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
关键词: IRF4 ; Interferon regulatory factor ; STAT6 ; c-Rel ; Zebrafish ; SVCV
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2015-07-01
DOI: 10.1016/j.dci.2015.02.018
卷: 51, 期:1, 页:65-73
收录类别: SCI
文章类型: Article
部门归属: [Li, Shun ; Guo, Xia ; Lu, Long-Feng ; Lu, Xiao-Bing ; Wu, Nan ; Zhang, Yong-An] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; [Guo, Xia ; Lu, Long-Feng ; Lu, Xiao-Bing] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Zoology
研究领域[WOS]: Immunology ; Zoology
英文摘要: Interferon regulatory factor 4 (IRF4) plays pivotal roles in both innate and adaptive immune responses in mammals. In fish, there are two homologues of irf4, irf4a and irf4b. In this study, we examined the regulatory patterns of zebrafish irf4a and irf4b by STAT6 and c-Rel. Firstly, expression of irf4a and irf4b was monitored in several tissues at mRNA level. By infection with SVCV, irf4a and irf4b were upregulated in both kidney and spleen, and were immediately induced by treatment with poly I:C in ZF4 cells. Moreover, the activation of irf4a promoter was regulated by overexpression of stat6 and c-rel in a cooperation manner, which could be inhibited by mutation of the putative binding sites of STAT6 and c-Rel in irf4a promoter region. However, irf4b promoter was activated slightly only by STAT6 but not c-Rel. Furthermore, overexpression of irf4a inhibited the activation of its own promoter under induction of STAT6 and c-Rel, which was the result of that IRF4a bound to STAT6 and c-Rel directly. In addition, cellular location analysis showed that IRF4a was located only in nuclear region. These data indicate that fish irf4a can also be upregulated by STAT6 and c-Rel. (C) 2015 Elsevier Ltd. All rights reserved.
关键词[WOS]: B-CELL DEVELOPMENT ; NF-KAPPA-B ; TRANSCRIPTION FACTOR ; INTERLEUKIN-4-INDUCED TRANSCRIPTION ; FACTOR FAMILY ; MATURE B ; EXPRESSION ; ACTIVATION ; VIRUSES ; DIFFERENTIATION
语种: 英语
WOS记录号: WOS:000357906800008
ISSN号: 0145-305X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23967
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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