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题名: Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae
作者: Zhu, Biran1, 2; Wang, Qiangwei1, 2; Wang, Xianfeng1, 2; Zhou, Bingsheng1
通讯作者: Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
关键词: Pb ; BDE-209 ; Co-exposure ; Thyroid disruption ; Thyroid hormones ; Synergistic effects
刊名: AQUATIC TOXICOLOGY
发表日期: 2014-12-01
DOI: 10.1016/j.aquatox.2014.10.011
卷: 157, 页:186-195
收录类别: SCI
文章类型: Article
部门归属: [Zhu, Biran ; Wang, Qiangwei ; Wang, Xianfeng ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Zhu, Biran ; Wang, Qiangwei ; Wang, Xianfeng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
英文摘要: Polybrominated diphenyl ethers (PBDEs) and metals are the main contaminants at waste electrical and electronic equipment ("e-waste") recycling sites. However, the potential environmental health effects of mixtures of PBDEs and metals are not known. We investigated co-exposure of lead (Pb) with decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Seven groups of embryos/larvae of zebrafish were treated with Pb (0, 2, 5, 10, 15, 20, and 30 mu g/L), six groups were exposed to BDE-209 (0, 50, 100, 200, 400, and 800 mu g/L), and nine groups of zebrafish larvae were treated with Pb and BDE-209 (5, 10, and 20 mu g/L Pb; 50, 100, and 200 mu g/L BDE-209). Embryos/larvae were exposed from 2 h post-fertilization (hpf) until 144 hpf, and thyroid hormone (TH) content measured. Pb exposure significantly decreased whole-body TH contents (triiodothyroxine (T-3) and thyroxine (T-4)) but BDE-209 exposure significantly increased T-3 and T-4 levels. Pb or BDE-209 treatment alone caused a predicted downregulation of TH transport (i.e., expression of the mRNA or proteins of transthyretin). Chemical analyses showed Pb uptake to be increased by BDE-209, but BDE-209 bioconcentration was decreased and the ability to metabolize BDE-209 was reduced in the presence of Pb. We also found that a mixture of the two chemicals had a synergistic effect on TH levels in zebrafish. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: POLYBROMINATED DIPHENYL ETHERS ; PEARL RIVER DELTA ; BROMINATED FLAME RETARDANTS ; TROUT ONCORHYNCHUS-MYKISS ; WASTE DISMANTLING REGION ; ELECTRONIC-WASTE ; SOUTH CHINA ; ENDOCRINE DISRUPTION ; POLYCHLORINATED-BIPHENYLS ; DEVELOPMENTAL EXPOSURE
语种: 英语
WOS记录号: WOS:000346547800020
ISSN号: 0166-445X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23959
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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