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Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae
Zhu, Biran1,2; Wang, Qiangwei1,2; Wang, Xianfeng1,2; Zhou, Bingsheng1; Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
2014-12-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume157Pages:186-195
AbstractPolybrominated diphenyl ethers (PBDEs) and metals are the main contaminants at waste electrical and electronic equipment ("e-waste") recycling sites. However, the potential environmental health effects of mixtures of PBDEs and metals are not known. We investigated co-exposure of lead (Pb) with decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Seven groups of embryos/larvae of zebrafish were treated with Pb (0, 2, 5, 10, 15, 20, and 30 mu g/L), six groups were exposed to BDE-209 (0, 50, 100, 200, 400, and 800 mu g/L), and nine groups of zebrafish larvae were treated with Pb and BDE-209 (5, 10, and 20 mu g/L Pb; 50, 100, and 200 mu g/L BDE-209). Embryos/larvae were exposed from 2 h post-fertilization (hpf) until 144 hpf, and thyroid hormone (TH) content measured. Pb exposure significantly decreased whole-body TH contents (triiodothyroxine (T-3) and thyroxine (T-4)) but BDE-209 exposure significantly increased T-3 and T-4 levels. Pb or BDE-209 treatment alone caused a predicted downregulation of TH transport (i.e., expression of the mRNA or proteins of transthyretin). Chemical analyses showed Pb uptake to be increased by BDE-209, but BDE-209 bioconcentration was decreased and the ability to metabolize BDE-209 was reduced in the presence of Pb. We also found that a mixture of the two chemicals had a synergistic effect on TH levels in zebrafish. (C) 2014 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordPb Bde-209 Co-exposure Thyroid Disruption Thyroid Hormones Synergistic Effects
Department[Zhu, Biran ; Wang, Qiangwei ; Wang, Xianfeng ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Zhu, Biran ; Wang, Qiangwei ; Wang, Xianfeng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
DOI10.1016/j.aquatox.2014.10.011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000346547800020
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; PEARL RIVER DELTA ; BROMINATED FLAME RETARDANTS ; TROUT ONCORHYNCHUS-MYKISS ; WASTE DISMANTLING REGION ; ELECTRONIC-WASTE ; SOUTH CHINA ; ENDOCRINE DISRUPTION ; POLYCHLORINATED-BIPHENYLS ; DEVELOPMENTAL EXPOSURE
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Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23959
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Biran,Wang, Qiangwei,Wang, Xianfeng,et al. Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2014,157:186-195.
APA Zhu, Biran,Wang, Qiangwei,Wang, Xianfeng,Zhou, Bingsheng,&Zhou, BS .(2014).Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae.AQUATIC TOXICOLOGY,157,186-195.
MLA Zhu, Biran,et al."Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae".AQUATIC TOXICOLOGY 157(2014):186-195.
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