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Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish
Wang, Qiangwei1,2; Lam, James Chung-Wah3,4,5; Man, Yin-Chung3,4,5; Lai, Nelson Lok-Shun3,4,5; Kwok, Karen Ying3,4,5; Guo, Yong Yong1; Lam, Paul Kwan-Sing3,4,5; Zhou, Bingsheng1; Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
2015
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume158Pages:108-115
AbstractOrganophosphate flame retardants are ubiquitous environmental contaminants; however, knowledge is limited regarding their environmental health risks and toxicity. Here, we investigated the effects of acute and long-term exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) to the nervous system of zebrafish. Zebrafish embryos (2 h post-fertilization) were exposed to TDCPP (0-100 mu g/L) for 6 months up until sexual maturation. Concentrations of TDCPP and its metabolic product (bis(1,3-dichloro-2-propyl) phosphate, BDCPP) were measured in the tissues of 5 day post-fertilization (dpf) larvae. There was no effect on locomotion, acetylcholinesterase activity, levels of the neurotransmitters dopamine and serotonin, and expression of mRNAs and proteins related to central nervous system development (e.g., myelin basic protein, alpha 1-tubulin) in any exposure group. However, in adult fish, reductions of dopamine and serotonin levels were detected in the brains of females but not males. Downregulation of nervous system development genes was observed in both the male and female brain tissues. TDCPP concentrations were measured in adult fish tissues including the brain, and greater levels were detected in females. Our results showed that females are more sensitive to TDCPP stress than males in terms of TDCPP-induced neurotoxicity. We demonstrate that long-term exposure to lower concentrations of TDCPP in fish can lead to neurotoxicity. (C) 2014 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordTdcpp Bioconcentration And Metabolism Neurotoxicity Gender-specific Toxicity Zebrafish
Department[Wang, Qiangwei ; Guo, Yong Yong ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Wang, Qiangwei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Lam, James Chung-Wah ; Man, Yin-Chung ; Lai, Nelson Lok-Shun ; Kwok, Karen Ying ; Lam, Paul Kwan-Sing] City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Peoples R China ; [Lam, James Chung-Wah ; Man, Yin-Chung ; Lai, Nelson Lok-Shun ; Kwok, Karen Ying ; Lam, Paul Kwan-Sing] City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Peoples R China ; [Lam, James Chung-Wah ; Man, Yin-Chung ; Lai, Nelson Lok-Shun ; Kwok, Karen Ying ; Lam, Paul Kwan-Sing] City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China
DOI10.1016/j.aquatox.2014.11.001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000348888400012
WOS KeywordMESSENGER-RNA EXPRESSION ; TANDEM MASS-SPECTROMETRY ; DIPHENYL ETHERS PBDES ; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE ; DEVELOPMENTAL NEUROTOXICITY ; ENDOCRINE DISRUPTION ; PROTEIN EXPRESSION ; NEONATAL EXPOSURE ; CHICKEN EMBRYOS ; HORMONE-LEVELS
Citation statistics
Cited Times:63[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23953
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Peoples R China
4.City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Peoples R China
5.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiangwei,Lam, James Chung-Wah,Man, Yin-Chung,et al. Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish[J]. AQUATIC TOXICOLOGY,2015,158:108-115.
APA Wang, Qiangwei.,Lam, James Chung-Wah.,Man, Yin-Chung.,Lai, Nelson Lok-Shun.,Kwok, Karen Ying.,...&Zhou, BS .(2015).Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish.AQUATIC TOXICOLOGY,158,108-115.
MLA Wang, Qiangwei,et al."Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish".AQUATIC TOXICOLOGY 158(2015):108-115.
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