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题名: Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish
作者: Wang, Qiangwei1, 2; Lam, James Chung-Wah3, 4, 5; Man, Yin-Chung3, 4, 5; Lai, Nelson Lok-Shun3, 4, 5; Kwok, Karen Ying3, 4, 5; Guo, Yong Yong1; Lam, Paul Kwan-Sing3, 4, 5; Zhou, Bingsheng1
通讯作者: Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
关键词: TDCPP ; Bioconcentration and metabolism ; Neurotoxicity ; Gender-specific toxicity ; Zebrafish
刊名: AQUATIC TOXICOLOGY
发表日期: 2015
DOI: 10.1016/j.aquatox.2014.11.001
卷: 158, 页:108-115
收录类别: SCI
文章类型: Article
部门归属: [Wang, Qiangwei ; Guo, Yong Yong ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Wang, Qiangwei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Lam, James Chung-Wah ; Man, Yin-Chung ; Lai, Nelson Lok-Shun ; Kwok, Karen Ying ; Lam, Paul Kwan-Sing] City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Peoples R China ; [Lam, James Chung-Wah ; Man, Yin-Chung ; Lai, Nelson Lok-Shun ; Kwok, Karen Ying ; Lam, Paul Kwan-Sing] City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Peoples R China ; [Lam, James Chung-Wah ; Man, Yin-Chung ; Lai, Nelson Lok-Shun ; Kwok, Karen Ying ; Lam, Paul Kwan-Sing] City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
英文摘要: Organophosphate flame retardants are ubiquitous environmental contaminants; however, knowledge is limited regarding their environmental health risks and toxicity. Here, we investigated the effects of acute and long-term exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) to the nervous system of zebrafish. Zebrafish embryos (2 h post-fertilization) were exposed to TDCPP (0-100 mu g/L) for 6 months up until sexual maturation. Concentrations of TDCPP and its metabolic product (bis(1,3-dichloro-2-propyl) phosphate, BDCPP) were measured in the tissues of 5 day post-fertilization (dpf) larvae. There was no effect on locomotion, acetylcholinesterase activity, levels of the neurotransmitters dopamine and serotonin, and expression of mRNAs and proteins related to central nervous system development (e.g., myelin basic protein, alpha 1-tubulin) in any exposure group. However, in adult fish, reductions of dopamine and serotonin levels were detected in the brains of females but not males. Downregulation of nervous system development genes was observed in both the male and female brain tissues. TDCPP concentrations were measured in adult fish tissues including the brain, and greater levels were detected in females. Our results showed that females are more sensitive to TDCPP stress than males in terms of TDCPP-induced neurotoxicity. We demonstrate that long-term exposure to lower concentrations of TDCPP in fish can lead to neurotoxicity. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: MESSENGER-RNA EXPRESSION ; TANDEM MASS-SPECTROMETRY ; DIPHENYL ETHERS PBDES ; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE ; DEVELOPMENTAL NEUROTOXICITY ; ENDOCRINE DISRUPTION ; PROTEIN EXPRESSION ; NEONATAL EXPOSURE ; CHICKEN EMBRYOS ; HORMONE-LEVELS
语种: 英语
WOS记录号: WOS:000348888400012
ISSN号: 0166-445X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23953
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.City Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong, Peoples R China
4.City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Peoples R China
5.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen 518057, Peoples R China
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