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Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish
Wang, Qiangwei1,2; Lam, James C. W.3; Han, Jian3; Wang, Xianfeng1; Guo, Yongyong1; Lam, Paul K. S.3; Zhou, Bingsheng1; Zhou, BS (reprint author), Chinese Acad Sci, Zhou Inst Hydrobiol, Wuhan 430072, Peoples R China.
2015-03-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume160Pages:163-171
AbstractTris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant that is detectable in the environment and biota, prompting concern over its risk to wildlife and human health. Our objective was to investigate whether long-term exposure to low concentrations of TDCPP can affect fish reproduction. Zebrafish embryos were exposed to low concentrations (0, 4, 20 and 100 mu g/L) of TDCPP from 2 h post-fertilization until sexual maturation. Exposure to TDCPP significantly increased plasma estradiol and testosterone levels in females, but had no effect in males. TDCPP exposure also caused a significant reduction in fecundity as indicated by decreased egg production. Real-time PCR was performed to examine selected genes in the hypothalamic-pituitary-gonadal (HPG) axis and liver. Principle component analysis (PCA) showed that sex hormone levels and fecundity were related to the mRNA level of several genes in the HPG axis. Furthermore, hepatic vitellogenin (vtg1 and vtg3) expression was upregulated in both females and males, suggesting TDCPP has estrogenic activity. Histological examination revealed promotion of oocyte maturation in the females, but retardation of spermiation in males. Reduced egg quality (e.g., egg diameter) and increased malformation rates were observed in the F1 generation. Chemical analysis showed significant levels of TDCPP and its metabolite bis(1,3-dichloro-2-propyl) phosphate in the gonads of males and females. In conclusion, long-term exposure to low concentrations of TDCPP impairs fish reproduction. (C) 2015 Elsevier B.V. All rights reserved.
SubtypeArticle
KeywordOrganophosphate Flame Retardant Tdcpp Bioconcentration Steroid Hormone Endocrine Disruption Reproduction Zebrafish
Department[Wang, Qiangwei ; Wang, Xianfeng ; Guo, Yongyong ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Wang, Qiangwei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Lam, James C. W. ; Han, Jian ; Lam, Paul K. S.] City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Hong Kong, Hong Kong, Peoples R China
DOI10.1016/j.aquatox.2015.01.014
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000350941000016
WOS KeywordMESSENGER-RNA EXPRESSION ; DIPHENYL ETHERS PBDES ; DANIO-RERIO ; GENE-EXPRESSION ; GONADOTROPIN RECEPTORS ; PIMEPHALES-PROMELAS ; SEX-DIFFERENTIATION ; MASS-SPECTROMETRY ; TREATMENT-PLANT ; TDCPP
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23949
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS (reprint author), Chinese Acad Sci, Zhou Inst Hydrobiol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiangwei,Lam, James C. W.,Han, Jian,et al. Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish[J]. AQUATIC TOXICOLOGY,2015,160:163-171.
APA Wang, Qiangwei.,Lam, James C. W..,Han, Jian.,Wang, Xianfeng.,Guo, Yongyong.,...&Zhou, BS .(2015).Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish.AQUATIC TOXICOLOGY,160,163-171.
MLA Wang, Qiangwei,et al."Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish".AQUATIC TOXICOLOGY 160(2015):163-171.
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