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题名: Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish
作者: Wang, Qiangwei1, 2; Lam, James C. W.3; Han, Jian3; Wang, Xianfeng1; Guo, Yongyong1; Lam, Paul K. S.3; Zhou, Bingsheng1
通讯作者: Zhou, BS (reprint author), Chinese Acad Sci, Zhou Inst Hydrobiol, Wuhan 430072, Peoples R China.
关键词: Organophosphate flame retardant ; TDCPP ; Bioconcentration ; Steroid hormone ; Endocrine disruption ; Reproduction ; Zebrafish
刊名: AQUATIC TOXICOLOGY
发表日期: 2015-03-01
DOI: 10.1016/j.aquatox.2015.01.014
卷: 160, 页:163-171
收录类别: SCI
文章类型: Article
部门归属: [Wang, Qiangwei ; Wang, Xianfeng ; Guo, Yongyong ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Wang, Qiangwei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Lam, James C. W. ; Han, Jian ; Lam, Paul K. S.] City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Hong Kong, Hong Kong, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
英文摘要: Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant that is detectable in the environment and biota, prompting concern over its risk to wildlife and human health. Our objective was to investigate whether long-term exposure to low concentrations of TDCPP can affect fish reproduction. Zebrafish embryos were exposed to low concentrations (0, 4, 20 and 100 mu g/L) of TDCPP from 2 h post-fertilization until sexual maturation. Exposure to TDCPP significantly increased plasma estradiol and testosterone levels in females, but had no effect in males. TDCPP exposure also caused a significant reduction in fecundity as indicated by decreased egg production. Real-time PCR was performed to examine selected genes in the hypothalamic-pituitary-gonadal (HPG) axis and liver. Principle component analysis (PCA) showed that sex hormone levels and fecundity were related to the mRNA level of several genes in the HPG axis. Furthermore, hepatic vitellogenin (vtg1 and vtg3) expression was upregulated in both females and males, suggesting TDCPP has estrogenic activity. Histological examination revealed promotion of oocyte maturation in the females, but retardation of spermiation in males. Reduced egg quality (e.g., egg diameter) and increased malformation rates were observed in the F1 generation. Chemical analysis showed significant levels of TDCPP and its metabolite bis(1,3-dichloro-2-propyl) phosphate in the gonads of males and females. In conclusion, long-term exposure to low concentrations of TDCPP impairs fish reproduction. (C) 2015 Elsevier B.V. All rights reserved.
关键词[WOS]: MESSENGER-RNA EXPRESSION ; DIPHENYL ETHERS PBDES ; DANIO-RERIO ; GENE-EXPRESSION ; GONADOTROPIN RECEPTORS ; PIMEPHALES-PROMELAS ; SEX-DIFFERENTIATION ; MASS-SPECTROMETRY ; TREATMENT-PLANT ; TDCPP
语种: 英语
WOS记录号: WOS:000350941000016
ISSN号: 0166-445X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23949
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Hong Kong, Hong Kong, Peoples R China
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