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Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin
Bai, Shijie1,2,4,5; Dai, Jingcheng1,2,3; Xia, Ming1,2; Ruan, Jing1,2; Wei, Hehong1,2; Yu, Dianzhen1,2; Li, Ronghui1,2; Jing, Hongmei4,5; Tian, Chunyuan3; Song, Lirong1,2; Qiu, Dongru1,2; Qiu, DR (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
2015-04-01
Source PublicationENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN0944-1344
Volume22Issue:7Pages:5531-5537
AbstractToxic Microcystis species are the main bloom-forming cyanobacteria in freshwaters. It is imperative to develop efficient techniques to control these notorious harmful algal blooms (HABs). Here, we present a simple, efficient, and environmentally safe algicidal way to control Microcystis blooms, by using intermediate carboxylic acids from the tricarboxylic acid (TCA) cycle. The citric acid, alpha-ketoglutaric acid, succinic acid, fumaric acid, and malic acid all exhibited strong algicidal effects, and particularly succinic acid could cause the rapid lysis of Microcystis in a few hours. It is revealed that the Microcystis-lysing activity of succinic acid and other carboxylic acids was due to their strong acidic activity. Interestingly, the acid-lysed Microcystis cells released large amounts of phycocyanin, about 27-fold higher than those of the control. On the other hand, the transcription of mcyA and mcyD of the microcystin biosynthesis operon was not upregulated by addition of alpha-ketoglutaric acid and other carboxylic acids. Consider the environmental safety of intermediate carboxylic acids. We propose that administration of TCA cycle organic acids may not only provide an algicidal method with high efficiency and environmental safety but also serve as an applicable way to produce and extract phycocyanin from cyanobacterial biomass.
SubtypeArticle
KeywordMicrocystis Blooms Carboxylic Acids Phycocyanin High Efficiency Environmental Safety
Department[Bai, Shijie ; Dai, Jingcheng ; Xia, Ming ; Ruan, Jing ; Wei, Hehong ; Yu, Dianzhen ; Li, Ronghui ; Song, Lirong ; Qiu, Dongru] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; [Bai, Shijie ; Dai, Jingcheng ; Xia, Ming ; Ruan, Jing ; Wei, Hehong ; Yu, Dianzhen ; Li, Ronghui ; Song, Lirong ; Qiu, Dongru] Univ Chinese Acad Sci, Wuhan 430072, Peoples R China ; [Dai, Jingcheng ; Tian, Chunyuan] Hubei Univ Engn, Sch Life Sci & Technol, Xiaogan 432000, Peoples R China ; [Bai, Shijie ; Jing, Hongmei] Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China ; [Bai, Shijie ; Jing, Hongmei] Univ Chinese Acad Sci, Sanya 572000, Peoples R China
DOI10.1007/s11356-014-3730-x
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS KeywordC-PHYCOCYANIN ; SPIRULINA-PLATENSIS ; FRESH-WATER ; PURIFICATION ; MARINE ; BLOOMS ; AERUGINOSA ; BIOMASS ; NTCA ; CYANOBACTERIA
WOS IDWOS:000351586500068
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23946
Collection水环境工程研究中心
Corresponding AuthorQiu, DR (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Wuhan 430072, Peoples R China
3.Hubei Univ Engn, Sch Life Sci & Technol, Xiaogan 432000, Peoples R China
4.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China
5.Univ Chinese Acad Sci, Sanya 572000, Peoples R China
Recommended Citation
GB/T 7714
Bai, Shijie,Dai, Jingcheng,Xia, Ming,et al. Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2015,22(7):5531-5537.
APA Bai, Shijie.,Dai, Jingcheng.,Xia, Ming.,Ruan, Jing.,Wei, Hehong.,...&Qiu, DR .(2015).Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,22(7),5531-5537.
MLA Bai, Shijie,et al."Effects of intermediate metabolite carboxylic acids of TCA cycle on Microcystis with overproduction of phycocyanin".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 22.7(2015):5531-5537.
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