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题名: Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae
作者: Miao, Wei1; Zhu, Biran2, 3; Xiao, Xiaohong4; Li, Ying1; Dirbaba, Niguse Bekele1; Zhou, Bingsheng2; Wu, Hongjuan1
通讯作者: Wu, HJ (reprint author), Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China.
关键词: Pb ; Titanium dioxide nanoparticles ; Bioconcentration ; Thyroid disruption ; Developmental neurotoxicity ; Zebrafish larvae
刊名: AQUATIC TOXICOLOGY
发表日期: 2015-04-01
DOI: 10.1016/j.aquatox.2015.02.002
卷: 161, 页:117-126
收录类别: SCI
文章类型: Review
部门归属: [Miao, Wei ; Li, Ying ; Dirbaba, Niguse Bekele ; Wu, Hongjuan] Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei, Peoples R China ; [Zhu, Biran ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Zhu, Biran] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China ; [Xiao, Xiaohong] China Univ Petr East China, Coll Mech & Elect Engn, Qingdao 266580, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
英文摘要: Nanoparticles (NPs) have attracted considerable attention because of their wide range of applications. Interactions between heavy metals (e.g., Pb) and NPs in aquatic environments may modify the bioavailability and toxicity of heavy metals. Therefore, this study investigated the influence of NPs (e.g., nano-TiO2) on the bioavailability and toxicity of Pb and its effects in the thyroid endocrine and nervous systems of zebrafish (Danio rerio) larvae. Zebrafish embryos (2-h post-fertilization) were exposed to five concentrations of Pb alone (0, 5, 10, 20, and 30 mu g/L) or in combination with nano-TiO2 (0.1 mg/L) until 6 days post-fertilization. Results showed that the bioconcentration of Pb was significantly enhanced when combined with nano-TiO2 than when used alone. Zebrafish exposure to Pb alone at 30 mu g/L significantly decreased the thyroid hormone levels (T-4 and T-3), whereas nano-TiO2 treatment alone did not produce detectable changes. The levels of T-4 and T-3 were further decreased when Pb was combined with nano-TiO2 than when used alone. The transcription of the thyroid hormone-related factor tg gene was remarkably down-regulated by Pb treatment alone but up-regulated when Pb was combined with nano-TiO2. The significant up-regulation of tsh beta gene and the down-regulation of TTR gene expression in the hypothalamic-pituitary-thyroid were observed in Pb with or without nano-TiO2 treatment groups. In addition, the transcription of genes involved in central nervous system (CNS) development (a-tubulin, mbp, gfap and shha) were significantly down-regulated by Pb and nano-TiO2 co-exposure as compared with Pb exposure alone. The locomotion activity analyzes confirmed that nano-TiO2 might enhance the toxicity of Pb to CNS development. These results suggest that nano-TiO2 increase bioconcentration of lead, which lead to the disruption of thyroid endocrine and neuronal system in zebrafish larvae. (C) 2015 Elsevier B.V. All rights reserved.
关键词[WOS]: DECABROMODIPHENYL ETHER BDE-209 ; GENE-EXPRESSION ; HEAVY-METALS ; SONIC HEDGEHOG ; DAPHNIA-MAGNA ; AQUEOUS SUSPENSIONS ; RAINBOW-TROUT ; PEARL RIVER ; RAT-BRAIN ; EXPOSURE
语种: 英语
WOS记录号: WOS:000352177500014
ISSN号: 0166-445X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23943
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
4.China Univ Petr East China, Coll Mech & Elect Engn, Qingdao 266580, Peoples R China
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