IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae
Miao, Wei1; Zhu, Biran2,3; Xiao, Xiaohong4; Li, Ying1; Dirbaba, Niguse Bekele1; Zhou, Bingsheng2; Wu, Hongjuan1; Wu, HJ (reprint author), Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China.
2015-04-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume161Pages:117-126
AbstractNanoparticles (NPs) have attracted considerable attention because of their wide range of applications. Interactions between heavy metals (e.g., Pb) and NPs in aquatic environments may modify the bioavailability and toxicity of heavy metals. Therefore, this study investigated the influence of NPs (e.g., nano-TiO2) on the bioavailability and toxicity of Pb and its effects in the thyroid endocrine and nervous systems of zebrafish (Danio rerio) larvae. Zebrafish embryos (2-h post-fertilization) were exposed to five concentrations of Pb alone (0, 5, 10, 20, and 30 mu g/L) or in combination with nano-TiO2 (0.1 mg/L) until 6 days post-fertilization. Results showed that the bioconcentration of Pb was significantly enhanced when combined with nano-TiO2 than when used alone. Zebrafish exposure to Pb alone at 30 mu g/L significantly decreased the thyroid hormone levels (T-4 and T-3), whereas nano-TiO2 treatment alone did not produce detectable changes. The levels of T-4 and T-3 were further decreased when Pb was combined with nano-TiO2 than when used alone. The transcription of the thyroid hormone-related factor tg gene was remarkably down-regulated by Pb treatment alone but up-regulated when Pb was combined with nano-TiO2. The significant up-regulation of tsh beta gene and the down-regulation of TTR gene expression in the hypothalamic-pituitary-thyroid were observed in Pb with or without nano-TiO2 treatment groups. In addition, the transcription of genes involved in central nervous system (CNS) development (a-tubulin, mbp, gfap and shha) were significantly down-regulated by Pb and nano-TiO2 co-exposure as compared with Pb exposure alone. The locomotion activity analyzes confirmed that nano-TiO2 might enhance the toxicity of Pb to CNS development. These results suggest that nano-TiO2 increase bioconcentration of lead, which lead to the disruption of thyroid endocrine and neuronal system in zebrafish larvae. (C) 2015 Elsevier B.V. All rights reserved.
SubtypeReview
KeywordPb Titanium Dioxide Nanoparticles Bioconcentration Thyroid Disruption Developmental Neurotoxicity Zebrafish Larvae
Department[Miao, Wei ; Li, Ying ; Dirbaba, Niguse Bekele ; Wu, Hongjuan] Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei, Peoples R China ; [Zhu, Biran ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Zhu, Biran] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China ; [Xiao, Xiaohong] China Univ Petr East China, Coll Mech & Elect Engn, Qingdao 266580, Peoples R China
DOI10.1016/j.aquatox.2015.02.002
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS IDWOS:000352177500014
WOS KeywordDECABROMODIPHENYL ETHER BDE-209 ; GENE-EXPRESSION ; HEAVY-METALS ; SONIC HEDGEHOG ; DAPHNIA-MAGNA ; AQUEOUS SUSPENSIONS ; RAINBOW-TROUT ; PEARL RIVER ; RAT-BRAIN ; EXPOSURE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23943
Collection水环境工程研究中心_期刊论文
Corresponding AuthorWu, HJ (reprint author), Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China.
Affiliation1.Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
4.China Univ Petr East China, Coll Mech & Elect Engn, Qingdao 266580, Peoples R China
Recommended Citation
GB/T 7714
Miao, Wei,Zhu, Biran,Xiao, Xiaohong,et al. Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2015,161:117-126.
APA Miao, Wei.,Zhu, Biran.,Xiao, Xiaohong.,Li, Ying.,Dirbaba, Niguse Bekele.,...&Wu, HJ .(2015).Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae.AQUATIC TOXICOLOGY,161,117-126.
MLA Miao, Wei,et al."Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae".AQUATIC TOXICOLOGY 161(2015):117-126.
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