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THE DEVELOPMENTAL NEUROTOXICITY OF POLYBROMINATED DIPHENYL ETHERS: EFFECT OF DE-71 ON DOPAMINE IN ZEBRAFISH LARVAE
Wang, Xianfeng1,2; Yang, Lihua1; Wu, Yuanyuan3; Huang, Changjiang3; Wang, Qiangwei1,2; Han, Jian1,2; Guo, Yongyong1; Shi, Xiongjie1; Zhou, Bingsheng1; Zhou, BS (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Peoples R China.
2015-05-01
Source PublicationENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
ISSN0730-7268
Volume34Issue:5Pages:1119-1126
AbstractThe potential neurotoxicity of polybrominated diphenyl ethers (PBDEs) is still a great concern. In the present study, the authors investigated whether exposure to PBDEs could affect the neurotransmitter system and cause developmental neurotoxicity in zebrafish. Zebrafish embryos (2h postfertilization) were exposed to different concentrations of the PBDE mixture DE-71(0-100g/L). The larvae were harvested at 120h postfertilization, and the impact on dopaminergic signaling was investigated. The results revealed significant reductions in content of whole-body dopamine and its metabolite, dihydroxyphenylacetic acid, in DE-71-exposed larvae. The transcription of genes involved in the development of dopaminergic neurons (e.g., manf, bdnf, and nr4a2b) was significantly downregulated upon exposure to DE-71. Also, DE-71 resulted in a significant decrease of tyrosine hydroxylase and dopamine transporter protein levels in dopaminergic neurons. The expression level of tyrosine hydroxylase in forebrain neurons was assessed by whole-mount immunofluorescence, and the results further demonstrated that the tyrosine hydroxylase protein expression level was reduced in dopaminergic neurons. In addition to these molecular changes, the authors observed reduced locomotor activity in DE-71-exposed larvae. Taken together, the results of the present study demonstrate that acute exposure to PBDEs can affect dopaminergic signaling by disrupting the synthesis and transportation of dopamine in zebrafish, thereby disrupting normal neurodevelopment. In accord with its experimental findings, the present study extends knowledge of the mechanisms governing PBDE-induced developmental neurotoxicity. Environ Toxicol Chem 2015;34:1119-1126. (c) 2015 SETAC
SubtypeArticle
KeywordPolybrominated Diphenyl Ethers (Pbdes) Neurotransmitter Dopaminergic Neuron Developing Neurotoxicity Zebrafish Larvae
Department[Wang, Xianfeng ; Yang, Lihua ; Wang, Qiangwei ; Han, Jian ; Guo, Yongyong ; Shi, Xiongjie ; Zhou, Bingsheng] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Peoples R China ; [Wang, Xianfeng ; Wang, Qiangwei ; Han, Jian] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Wu, Yuanyuan ; Huang, Changjiang] Wenzhou Med Univ, Inst Watershed Sci & Environm Ecol, Wenzhou, Peoples R China
DOI10.1002/etc.2906
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS SubjectEnvironmental Sciences ; Toxicology
WOS IDWOS:000353412800025
WOS KeywordPOLYCHLORINATED-BIPHENYLS ; TYROSINE-HYDROXYLASE ; NEONATAL EXPOSURE ; BRAIN ; RATS ; TRANSPORTER ; EXPRESSION ; SYSTEMS ; SYNAPTOSOMES ; LOCOMOTION
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23941
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Peoples R China.
Affiliation1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Wenzhou Med Univ, Inst Watershed Sci & Environm Ecol, Wenzhou, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xianfeng,Yang, Lihua,Wu, Yuanyuan,et al. THE DEVELOPMENTAL NEUROTOXICITY OF POLYBROMINATED DIPHENYL ETHERS: EFFECT OF DE-71 ON DOPAMINE IN ZEBRAFISH LARVAE[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2015,34(5):1119-1126.
APA Wang, Xianfeng.,Yang, Lihua.,Wu, Yuanyuan.,Huang, Changjiang.,Wang, Qiangwei.,...&Zhou, BS .(2015).THE DEVELOPMENTAL NEUROTOXICITY OF POLYBROMINATED DIPHENYL ETHERS: EFFECT OF DE-71 ON DOPAMINE IN ZEBRAFISH LARVAE.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,34(5),1119-1126.
MLA Wang, Xianfeng,et al."THE DEVELOPMENTAL NEUROTOXICITY OF POLYBROMINATED DIPHENYL ETHERS: EFFECT OF DE-71 ON DOPAMINE IN ZEBRAFISH LARVAE".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 34.5(2015):1119-1126.
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