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Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae
Wang, Qiangwei1,2; Lai, Nelson Lok-Shun3,4,5; Wang, Xianfeng1,2; Guo, Yongyong1; Lam, Paul Kwan-Sing3,4,5; Lam, James Chung-Wah4; Zhou, Bingsheng1; Lam, JCW (reprint author), City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China.
2015-04-21
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume49Issue:8Pages:5123-5132
AbstractOrganophosphate flame retardants are emerging environmental contaminants, although knowledge of their health risks is limited. Here, thyroid hormone homeostasis and neuronal development was studied in the progeny of adult zebrafish exposed to tris(1,3-dichloro-2-propyl) phosphate (TDCPP). Adult zebrafish were exposed to TDCPP (0, 4, 20, and 100 mu g/L) for 3 months. Increased generation of a reactive oxygen species and reduced survival rates was observed in exposed F1 larvae. We also observed a significant decrease in plasma thyroxine and 3,5,3'-triiodothyronine levels in F0 females and F1 eggs/larvae. The mRNA and protein expression of factors associated with neuronal development (e.g., alpha 1-tubulin, myelin basic protein, and synapsin ha) were significantly downregulated in exposed F1 larvae, as was the level of the neurotransmitters dopamine, serotonin, gamma amino butyric acid, and histamine. Larval locomotion was significantly decreased in exposed fish, but there was no effect on acetylcholinesterase activity. Bioconcentration of TDCPP was observed in F0 fish. TDCPP was also detected in F1 eggs following parental exposure, indicating maternal transfer of this compound. This study uniquely shows that TDCPP can be transferred to the offspring of exposed adults, causing thyroid endocrine disruption and developmental neurotoxicity.
SubtypeArticle
Department[Wang, Qiangwei ; Wang, Xianfeng ; Guo, Yongyong ; Zhou, Bingsheng] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China ; [Wang, Qiangwei ; Wang, Xianfeng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Lai, Nelson Lok-Shun ; Lam, Paul Kwan-Sing] City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China ; [Lai, Nelson Lok-Shun ; Lam, Paul Kwan-Sing ; Lam, James Chung-Wah] City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen Key Lab Sustainable Use Marine Biodivers, Shenzhen 518057, Guangdong, Peoples R China ; [Lai, Nelson Lok-Shun ; Lam, Paul Kwan-Sing] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
DOI10.1021/acs.est.5b00558
WOS HeadingsScience & Technology ; Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
WOS KeywordPOLYBROMINATED DIPHENYL ETHERS ; MESSENGER-RNA EXPRESSION ; MATERNAL TRANSFER ; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE ; HORMONE-LEVELS ; POLYCHLORINATED-BIPHENYLS ; ENVIRONMENTAL CHEMICALS ; TISSUE DISTRIBUTION ; MASS-SPECTROMETRY ; SOUTH CHINA
WOS IDWOS:000353610300041
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23938
Collection水环境工程研究中心
Corresponding AuthorLam, JCW (reprint author), City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China.
Affiliation1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
4.City Univ Hong Kong, Res Ctr Oceans & Human Hlth, Shenzhen Key Lab Sustainable Use Marine Biodivers, Shenzhen 518057, Guangdong, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiangwei,Lai, Nelson Lok-Shun,Wang, Xianfeng,et al. Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2015,49(8):5123-5132.
APA Wang, Qiangwei.,Lai, Nelson Lok-Shun.,Wang, Xianfeng.,Guo, Yongyong.,Lam, Paul Kwan-Sing.,...&Lam, JCW .(2015).Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae.ENVIRONMENTAL SCIENCE & TECHNOLOGY,49(8),5123-5132.
MLA Wang, Qiangwei,et al."Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae".ENVIRONMENTAL SCIENCE & TECHNOLOGY 49.8(2015):5123-5132.
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