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题名: The impact of long term exposure to phthalic acid esters on reproduction in Chinese rare minnow (Gobiocypris rarus)
作者: Guo, Yongyong1; Yang, Yuanjin2; Gao, Yong2; Wang, Xianfeng1; Zhou, Bingsheng1
通讯作者: Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
关键词: Di-(2-ethylhexyl)-phthalate ; Endocrine disruption ; Reproductive toxicity ; Environmental risk ; Chinese rare minnow
刊名: ENVIRONMENTAL POLLUTION
发表日期: 2015-08-01
DOI: 10.1016/j.envpol.2015.04.005
卷: 203, 页:130-136
收录类别: SCI
文章类型: Article
部门归属: [Guo, Yongyong ; Wang, Xianfeng ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Yang, Yuanjin ; Gao, Yong] China Three Gorges Corp, Inst Chinese Sturgeon Res, Yichang, Hubei, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
英文摘要: The environmental risk of phthalic acid esters (PAEs) is of great concern. We investigated the reproductive impairment of di-(2-ethylhexyl)-phthalate (DEHP) on Chinese rare minnow, an endemic fish inhabiting the upper streams of the Yangtze River. Chinese rare minnow larvae were exposed to environmentally relevant concentrations of DEHP (0, 4.2, 13.3, and 40.8 mu g/L) for 6 months. Plasma testosterone and 17 beta-estradiol levels decreased in females, accompanied by downregulation of cyp19a and cyp17 gene transcription in ovary. Increases in plasma testosterone concentration were observed in males, accompanied by downregulation of cyp19a gene transcription in testes. Hepatic VTG gene transcription was upregulated in males and females. Exposure to DEHP reduced egg production and inhibited oocyte maturation in females and retarded spermiation in males. Decreased egg protein content was measured in F1 embryos. These results indicate that long-term exposure to low concentrations of DEHP (13.3 mu g/L) causes endocrine disruption and impairs fish reproduction. (C) 2015 Elsevier Ltd. All rights reserved.
关键词[WOS]: THREE-GORGES DAM ; YANGTZE-RIVER ; ENDOCRINE DISRUPTION ; GENE-EXPRESSION ; FATHEAD MINNOW ; SURFACE-WATER ; DANIO-RERIO ; IN-VITRO ; CONTAMINATION ; TESTOSTERONE
语种: 英语
WOS记录号: WOS:000356643000015
ISSN号: 0269-7491
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23932
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.China Three Gorges Corp, Inst Chinese Sturgeon Res, Yichang, Hubei, Peoples R China
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