[Guo, Yongyong
; Wang, Xianfeng
; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
; [Yang, Yuanjin
; Gao, Yong] China Three Gorges Corp, Inst Chinese Sturgeon Res, Yichang, Hubei, Peoples R China
WOS标题词:
Science & Technology
; Life Sciences & Biomedicine
类目[WOS]:
Environmental Sciences
研究领域[WOS]:
Environmental Sciences & Ecology
英文摘要:
The environmental risk of phthalic acid esters (PAEs) is of great concern. We investigated the reproductive impairment of di-(2-ethylhexyl)-phthalate (DEHP) on Chinese rare minnow, an endemic fish inhabiting the upper streams of the Yangtze River. Chinese rare minnow larvae were exposed to environmentally relevant concentrations of DEHP (0, 4.2, 13.3, and 40.8 mu g/L) for 6 months. Plasma testosterone and 17 beta-estradiol levels decreased in females, accompanied by downregulation of cyp19a and cyp17 gene transcription in ovary. Increases in plasma testosterone concentration were observed in males, accompanied by downregulation of cyp19a gene transcription in testes. Hepatic VTG gene transcription was upregulated in males and females. Exposure to DEHP reduced egg production and inhibited oocyte maturation in females and retarded spermiation in males. Decreased egg protein content was measured in F1 embryos. These results indicate that long-term exposure to low concentrations of DEHP (13.3 mu g/L) causes endocrine disruption and impairs fish reproduction. (C) 2015 Elsevier Ltd. All rights reserved.
1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.China Three Gorges Corp, Inst Chinese Sturgeon Res, Yichang, Hubei, Peoples R China
