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题名: Cloning of Interleukin-10 from African Clawed Frog (Xenopus tropicalis), with the Finding of IL-19/20 Homologue in the IL-10 Locus
作者: Qi, Zhitao1, 2; Zhang, Qihuan2; Wang, Zisheng1; Zhao, Weihong1, 2; Gao, Qian3
通讯作者: Qi, ZT (reprint author), Yancheng Inst Technol, Dept Ocean Technol, Key Lab Aquaculture & Ecol Coastal Pool Jiangsu P, Yancheng 224051, Jiangsu, Peoples R China.
刊名: JOURNAL OF IMMUNOLOGY RESEARCH
发表日期: 2015
DOI: 10.1155/2015/462138
期: *
收录类别: SCI
文章类型: Article
部门归属: [Qi, Zhitao ; Wang, Zisheng ; Zhao, Weihong] Yancheng Inst Technol, Dept Ocean Technol, Key Lab Aquaculture & Ecol Coastal Pool Jiangsu P, Yancheng 224051, Jiangsu, Peoples R China ; [Qi, Zhitao ; Zhang, Qihuan ; Zhao, Weihong] Yancheng Inst Technol, Chem & Biol Engn Coll, Cent Lab Biol, Yancheng 224051, Jiangsu, Peoples R China ; [Gao, Qian] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Hubei, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology
研究领域[WOS]: Immunology
英文摘要: Interleukin-10 (IL-10) is a pleiotropic cytokine that plays an important role in immune system. In the present study, the IL-10 gene of African clawed frog (Xenopus tropicalis) was first cloned, and its expression pattern and 3D structure were also analyzed. The frog IL-10 mRNA encoded 172 amino acids which possessed several conserved features found in IL-10s from other species, including five-exon/four-intron genomic structure, conserved four cysteine residues, IL-10 family motif, and six alpha-helices. Real-time PCR showed that frog IL-10 mRNA was ubiquitous expressed in all examined tissues, highly in some immune related tissues including kidney, spleen, and intestine and lowly in heart, stomach, and liver. The frog IL-10 mRNA was upregulated at 24 h after LPS stimulation, indicating that it plays a part in the host immune response to bacterial infection. Another IL, termed as IL-20, was identified from the frog IL-10 locus, which might be the homologue of mammalian IL-19/20 according to the analysis results of the phylogenetic tree and the sequence identities.
关键词[WOS]: CRYSTAL-STRUCTURE ; PREDICTION ; CYTOKINE ; GENE ; IDENTIFICATION ; EXPRESSION ; IFN ; ALIGNMENT ; SEQUENCE ; REVEALS
语种: 英语
WOS记录号: WOS:000350149300001
ISSN号: 2314-8861
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23926
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Yancheng Inst Technol, Dept Ocean Technol, Key Lab Aquaculture & Ecol Coastal Pool Jiangsu P, Yancheng 224051, Jiangsu, Peoples R China
2.Yancheng Inst Technol, Chem & Biol Engn Coll, Cent Lab Biol, Yancheng 224051, Jiangsu, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Hubei, Peoples R China
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