IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心
Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)
Feng, Xiu1,2; Yu, Xiaomu1; Tong, Jingou1; Tong, JG (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
2014-12-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume15Issue:12Pages:22471-22482
AbstractInsulin-like growth factor-I (IGF-I) plays an important role in the growth and development of vertebrates. To study polymorphisms of IGF-I, we screened a total of 4555 bp of genomic sequences in four exons and partial introns for the discovery of single nucleotide polymorphism (SNP) in common carp (Cyprinus carpio). Three SNPs (g. 3759T> G, g. 7627T> A and g. 7722T> C) in intron 2 and a nonsynonymous SNP (g. 7892C> T) in exon 3 were identified in a pilot population including random parents and their progenies. 289 progenies were further genotyped for studying possible associations between genotypes or combined genotypes and growth traits. The results showed that the locus g. 7627T> A was significantly associated with body weight and body length, and fish with genotype AA had a mean body weight 5.9% higher than those with genotype TT. No significant associations were observed between genotypes of other loci and growth traits. However, when both g. 7627T> A and g. 7722T> C were considered, the combined genotype TT/TT was extremely associated with the lowest values of body length and body weight and the highest K value in comparison with other diplotypes (p < 0.01). These results suggest that genotype AA at g. 7627T> A and its combined genotypes with alleles from another locus have positive effects on growth traits, which would be a candidate molecular marker for further studies in marker-assisted selection in common carp.
SubtypeArticle
KeywordCommon Carp Igf-i Snp Growth Trait Association Study
Department[Feng, Xiu ; Yu, Xiaomu ; Tong, Jingou] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Feng, Xiu] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
DOI10.3390/ijms151222471
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS KeywordIGF-I ; 5'-FLANKING REGION ; ATLANTIC SALMON ; CANDIDATE GENES ; HORMONE GENE ; SEQUENCE ; WEIGHT ; CATTLE ; POPULATION ; EFFICIENCY
WOS IDWOS:000346797400054
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23922
Collection鱼类生物学及渔业生物技术研究中心
Corresponding AuthorTong, JG (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Feng, Xiu,Yu, Xiaomu,Tong, Jingou,et al. Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(12):22471-22482.
APA Feng, Xiu,Yu, Xiaomu,Tong, Jingou,&Tong, JG .(2014).Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,15(12),22471-22482.
MLA Feng, Xiu,et al."Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15.12(2014):22471-22482.
Files in This Item:
File Name/Size DocType Version Access License
Novel Single Nucleot(811KB) 开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Feng, Xiu]'s Articles
[Yu, Xiaomu]'s Articles
[Tong, Jingou]'s Articles
Baidu academic
Similar articles in Baidu academic
[Feng, Xiu]'s Articles
[Yu, Xiaomu]'s Articles
[Tong, Jingou]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Feng, Xiu]'s Articles
[Yu, Xiaomu]'s Articles
[Tong, Jingou]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.).pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.