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题名: Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish
作者: Zou, Peng Fei1, 2; Chang, Ming Xian2; Li, Ying3; Zhang, Shu Huan2; Fu, Jian Ping2; Chen, Shan Nan2; Nie, Pin2
通讯作者: Chang, MX (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China.
关键词: Retinoic acid-inducible gene-I ; Variant ; Type I IFN production ; Mitochondrial antiviral signaling protein ; RIG-lb/MAVS-mediated signaling pathway
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2015-03-01
DOI: 10.1016/j.fsi.2014.12.001
卷: 43, 期:1, 页:13-24
收录类别: SCI
文章类型: Article
部门归属: [Zou, Peng Fei] Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian Province, Peoples R China ; [Zou, Peng Fei ; Chang, Ming Xian ; Zhang, Shu Huan ; Fu, Jian Ping ; Chen, Shan Nan ; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China ; [Li, Ying] Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei Province, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
研究领域[WOS]: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
英文摘要: As an intracellular pattern recognition receptor (PRR), the retinoic acid-inducible gene-I (RIG-I) is responsible for the recognition of cytosolic viral nucleic acids and the production of type I interferons (IFNs). In the present study, an insertion variant of RIG-I with 38 amino acids inserted in the N-terminal CARD2 domain, as well as the typical type, named as RIG-Ia and RIG-Ib respectively were identified in zebrafish. RIG-la and RIG-Ib were all up-regulated following the infection of a negative ssRNA virus, the Spring Viremia of Carp Virus (SVCV), and an intracellular Gram-negative bacterial pathogen Edwardsiella tarda, indicating the RLR may have a role in the recognition of both viruses and bacteria. The overexpression of RIG-Ib in cultured fish cells resulted in significant increase in type I IFN promoter activity, and in protection against SVCV infection, whereas the over-expression of RIG-Ia had no direct effect on IFN activation nor antiviral response. Furthermore, it was revealed that both RIG-Ia and RIG-Ib were associated with the downstream molecular mitochondrial antiviral signaling protein, MAVS, and interestingly RIG-Ia when co-transfected with RIG-Ib or MAVS, induced a significantly higher level of type IFN promoter activity and the expression level of Mx and IRF7, implying that the RIG-la may function as an enhancer in the RIG-Ib/MAVS-mediated signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved.
关键词[WOS]: INNATE IMMUNE-RESPONSE ; INDUCIBLE GENE-I ; PATHOGEN RECOGNITION ; VIRAL-INFECTION ; RNA VIRUSES ; MDA5 ; RECEPTORS ; ACTIVATION ; LGP2 ; IDENTIFICATION
语种: 英语
WOS记录号: WOS:000349731400002
ISSN号: 1050-4648
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23906
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Jimei Univ, Coll Fisheries, Xiamen 361021, Fujian Province, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
3.Huazhong Univ Sci & Technol, Sch Environm Sci & Engn, Wuhan 430074, Hubei Province, Peoples R China
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