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题名: Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)
作者: Xiao, Zhangang1, 2; Shen, Jing2; Feng, Hong1; Liu, Hong3; Wang, Yaping1; Huang, Rong1; Guo, Qionglin1
通讯作者: Xiao, ZG (reprint author), Chinese Univ Hong Kong, Lo Kwee Seong Integrated Biomed Sci Bldg,Rm 507, Hong Kong, Hong Kong, Peoples R China.
关键词: prothymosin alpha (ProT alpha) ; beta thymosin (T beta) ; Common carp ; Spring viraemia of carp virus (SVCV)
刊名: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
发表日期: 2015-05-01
DOI: 10.1016/j.dci.2015.01.003
卷: 50, 期:1, 页:29-37
收录类别: SCI
文章类型: Article
部门归属: [Xiao, Zhangang ; Feng, Hong ; Wang, Yaping ; Huang, Rong ; Guo, Qionglin] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; [Xiao, Zhangang ; Shen, Jing] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China ; [Liu, Hong] Shenzhen Exit & Entry Inspect & Quarantine Bur, Key Lab Aquat Anim Dis, Shenzhen 518001, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Zoology
研究领域[WOS]: Immunology ; Zoology
英文摘要: Prothymosin alpha (ProT alpha) and thymosin beta (T beta) belong to thymosin family, which consists of a series of highly conserved peptides involved in stimulating immune responses. ProT alpha b and T beta are still poorly studied in teleost. Here, the full-length cDNAs of ProT alpha b and T beta-like (T beta-l) were cloned and identified in common carp (Cyprinus carpi L). The expressions of carp ProT alpha b and T beta-l exhibited rise-fall pattern and then trended to be stable during early development. After spring viraemia of carp virus (SVCV) infection, the carp ProT alpha b and T beta-l transcripts were significantly up-regulated in some immune-related organs. When transiently over-expressed carp ProT alpha b and T beta-l in zebrafish, these two proteins upregulated the expressions of T lymphocytes-related genes (Rag 1, TCR-gamma, CD4 and CD8 alpha). These results suggest that carp ProT alpha b and T beta may ultimately enhance the immune response during viral infection and modulate the development of T lymphocytes in teleost. (C) 2015 Elsevier Ltd. All rights reserved.
关键词[WOS]: HUMAN PROTHYMOSIN-ALPHA ; DIFFERENTIAL EXPRESSION ; SPRING VIREMIA ; BETA-THYMOSINS ; MESSENGER-RNA ; RAT-TISSUES ; VIRUS SVCV ; IN-VITRO ; IDENTIFICATION ; CELLS
语种: 英语
WOS记录号: WOS:000350931900005
ISSN号: 0145-305X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23903
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China
3.Shenzhen Exit & Entry Inspect & Quarantine Bur, Key Lab Aquat Anim Dis, Shenzhen 518001, Peoples R China
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