IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)
Xiao, Zhangang1,2; Shen, Jing2; Feng, Hong1; Liu, Hong3; Wang, Yaping1; Huang, Rong1; Guo, Qionglin1; Xiao, ZG (reprint author), Chinese Univ Hong Kong, Lo Kwee Seong Integrated Biomed Sci Bldg,Rm 507, Hong Kong, Hong Kong, Peoples R China.
2015-05-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume50Issue:1Pages:29-37
AbstractProthymosin alpha (ProT alpha) and thymosin beta (T beta) belong to thymosin family, which consists of a series of highly conserved peptides involved in stimulating immune responses. ProT alpha b and T beta are still poorly studied in teleost. Here, the full-length cDNAs of ProT alpha b and T beta-like (T beta-l) were cloned and identified in common carp (Cyprinus carpi L). The expressions of carp ProT alpha b and T beta-l exhibited rise-fall pattern and then trended to be stable during early development. After spring viraemia of carp virus (SVCV) infection, the carp ProT alpha b and T beta-l transcripts were significantly up-regulated in some immune-related organs. When transiently over-expressed carp ProT alpha b and T beta-l in zebrafish, these two proteins upregulated the expressions of T lymphocytes-related genes (Rag 1, TCR-gamma, CD4 and CD8 alpha). These results suggest that carp ProT alpha b and T beta may ultimately enhance the immune response during viral infection and modulate the development of T lymphocytes in teleost. (C) 2015 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordProthymosin Alpha (Prot Alpha) Beta Thymosin (t Beta) Common Carp Spring Viraemia Of Carp Virus (Svcv)
Department[Xiao, Zhangang ; Feng, Hong ; Wang, Yaping ; Huang, Rong ; Guo, Qionglin] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; [Xiao, Zhangang ; Shen, Jing] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China ; [Liu, Hong] Shenzhen Exit & Entry Inspect & Quarantine Bur, Key Lab Aquat Anim Dis, Shenzhen 518001, Peoples R China
DOI10.1016/j.dci.2015.01.003
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Zoology
WOS SubjectImmunology ; Zoology
WOS IDWOS:000350931900005
WOS KeywordHUMAN PROTHYMOSIN-ALPHA ; DIFFERENTIAL EXPRESSION ; SPRING VIREMIA ; BETA-THYMOSINS ; MESSENGER-RNA ; RAT-TISSUES ; VIRUS SVCV ; IN-VITRO ; IDENTIFICATION ; CELLS
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23903
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorXiao, ZG (reprint author), Chinese Univ Hong Kong, Lo Kwee Seong Integrated Biomed Sci Bldg,Rm 507, Hong Kong, Hong Kong, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China
3.Shenzhen Exit & Entry Inspect & Quarantine Bur, Key Lab Aquat Anim Dis, Shenzhen 518001, Peoples R China
Recommended Citation
GB/T 7714
Xiao, Zhangang,Shen, Jing,Feng, Hong,et al. Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,50(1):29-37.
APA Xiao, Zhangang.,Shen, Jing.,Feng, Hong.,Liu, Hong.,Wang, Yaping.,...&Xiao, ZG .(2015).Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.).DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,50(1),29-37.
MLA Xiao, Zhangang,et al."Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 50.1(2015):29-37.
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