| Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation | |
| Pei, Y. Y.1,2; Huang, R.1; Li, Y. M.1; Liao, L. J.1; Zhu, Z. Y.1; Wang, Y. P.1; Wang, YP (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. | |
| 2015-03-01 | |
| Source Publication | JOURNAL OF FISH BIOLOGY
 |
| ISSN | 0022-1112 |
| Volume | 86Issue:3Pages:1098-1108 |
| Abstract | In this study, the subcellular localization, tissue distribution and response to grass carp reovirus (GCRV) infection and lipopolysaccharide (LPS) stimulation of four grass carp Ctenopharyngodon idellus toll-like receptor 4 (tlr4) genes were investigated. All four genes were constitutively expressed in all tissues studied, but the subcellular localization and tissue exhibiting the highest expression differed for each protein. Following GCRV infection, all the four tlr4s were upregulated in all tissues examined, and stimulation of C. idellus kidney (CIK) cells with LPS resulted in downregulation of all four tlr4s. These results provide a foundation for further investigation of tlr4 genes in bony fishes. (C) 2015 The Fisheries Society of the British Isles |
| Subtype | Article |
| Keyword | Gene Expression Grass Carp Reovirus Subcellular Localization Tissue Distribution Virus Infection |
| Department | [Pei, Y. Y. ; Huang, R. ; Li, Y. M. ; Liao, L. J. ; Zhu, Z. Y. ; Wang, Y. P.] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Pei, Y. Y.] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| DOI | 10.1111/jfb.12617 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Fisheries ; Marine & Freshwater Biology |
| WOS Subject | Fisheries ; Marine & Freshwater Biology |
| WOS ID | WOS:000351356700013 |
| WOS Keyword | CATFISH ICTALURUS-PUNCTATUS ; RESPIRATORY SYNCYTIAL VIRUS ; GENE FAMILY ; PATHOGEN RECOGNITION ; CHANNEL CATFISH ; INNATE IMMUNITY ; TLR4 GENE ; SIGNAL-TRANSDUCTION ; EXPRESSION ANALYSIS ; PATHWAY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/23901 |
| Collection | 鱼类生物学及渔业生物技术研究中心_期刊论文 |
| Corresponding Author | Wang, YP (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. |
| Affiliation | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Pei, Y. Y.,Huang, R.,Li, Y. M.,et al. Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation[J]. JOURNAL OF FISH BIOLOGY,2015,86(3):1098-1108. |
| APA | Pei, Y. Y..,Huang, R..,Li, Y. M..,Liao, L. J..,Zhu, Z. Y..,...&Wang, YP .(2015).Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation.JOURNAL OF FISH BIOLOGY,86(3),1098-1108. |
| MLA | Pei, Y. Y.,et al."Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation".JOURNAL OF FISH BIOLOGY 86.3(2015):1098-1108. |
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