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题名: Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation
作者: Pei, Y. Y.1, 2; Huang, R.1; Li, Y. M.1; Liao, L. J.1; Zhu, Z. Y.1; Wang, Y. P.1
通讯作者: Wang, YP (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
关键词: gene expression ; grass carp reovirus ; subcellular localization ; tissue distribution ; virus infection
刊名: JOURNAL OF FISH BIOLOGY
发表日期: 2015-03-01
DOI: 10.1111/jfb.12617
卷: 86, 期:3, 页:1098-1108
收录类别: SCI
文章类型: Article
部门归属: [Pei, Y. Y. ; Huang, R. ; Li, Y. M. ; Liao, L. J. ; Zhu, Z. Y. ; Wang, Y. P.] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Pei, Y. Y.] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Fisheries ; Marine & Freshwater Biology
研究领域[WOS]: Fisheries ; Marine & Freshwater Biology
英文摘要: In this study, the subcellular localization, tissue distribution and response to grass carp reovirus (GCRV) infection and lipopolysaccharide (LPS) stimulation of four grass carp Ctenopharyngodon idellus toll-like receptor 4 (tlr4) genes were investigated. All four genes were constitutively expressed in all tissues studied, but the subcellular localization and tissue exhibiting the highest expression differed for each protein. Following GCRV infection, all the four tlr4s were upregulated in all tissues examined, and stimulation of C. idellus kidney (CIK) cells with LPS resulted in downregulation of all four tlr4s. These results provide a foundation for further investigation of tlr4 genes in bony fishes. (C) 2015 The Fisheries Society of the British Isles
关键词[WOS]: CATFISH ICTALURUS-PUNCTATUS ; RESPIRATORY SYNCYTIAL VIRUS ; GENE FAMILY ; PATHOGEN RECOGNITION ; CHANNEL CATFISH ; INNATE IMMUNITY ; TLR4 GENE ; SIGNAL-TRANSDUCTION ; EXPRESSION ANALYSIS ; PATHWAY
语种: 英语
WOS记录号: WOS:000351356700013
ISSN号: 0022-1112
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23901
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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