IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies
Tang, Haipei1,2; Liu, Yun1,3,6; Luo, Daji4,5; Ogawa, Satoshi7; Yin, Yike2; Li, Shuisheng1,2; Zhang, Yong1,2,3; Hu, Wei4; Parhar, Ishwar S.7; Lin, Haoran1,2; Liu, Xiaochun1,2; Cheng, Christopher H. K.3,6; Cheng, CHK (reprint author), Chinese Univ Hong Kong, Room 604A,6-F, Shatin, Hong Kong, Peoples R China.
2015-02-01
Source PublicationENDOCRINOLOGY
ISSN0013-7227
Volume156Issue:2Pages:589-599
AbstractThe kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in most vertebrates. However, this presumption has not been tested vigorously in nonmammalian vertebrates. Distinct from mammals, multiple kiss1/gpr54 paralogous genes (kiss/kissr) have been identified in nonmammalian vertebrates, raising the possibility of functional redundancy among these genes. In this study, we have systematically generated the zebrafish kiss1(-/-), kiss2(-/-), and kiss1(-/-); kiss2-/- mutant lines as well as the kissr1(-/-), kissr2(-/-), and kissr1(-/-); kissr2(-/-) mutant lines using transcription activator-like effector nucleases. We have demonstrated that spermatogenesis and folliculogenesis as well as reproductive capability are not impaired in all of these 6 mutant lines. Collectively, our results indicate that kiss/kissr signaling is not absolutely required for zebrafish reproduction, suggesting that the kiss/kissr systems play nonessential roles for reproduction in certain nonmammalian vertebrates. These findings also demonstrated that fish and mammals have evolved different strategies for neuroendocrine control of reproduction.
SubtypeArticle
Department[Tang, Haipei ; Liu, Yun ; Li, Shuisheng ; Zhang, Yong ; Lin, Haoran ; Liu, Xiaochun] Sun Yat Sen Univ, Sch Life Sci, Inst Aquat Econ Anim, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China ; [Tang, Haipei ; Yin, Yike ; Li, Shuisheng ; Zhang, Yong ; Lin, Haoran ; Liu, Xiaochun] Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Guangdong, Peoples R China ; [Liu, Yun ; Zhang, Yong ; Cheng, Christopher H. K.] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China ; [Luo, Daji ; Hu, Wei] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Peoples R China ; [Luo, Daji] Wuhan Univ, Sch Basic Med Sci, Dept Genet, Wuhan 430072, Peoples R China ; [Liu, Yun ; Cheng, Christopher H. K.] Chinese Univ Hong Kong, Shenzhen Res Inst, Sch Biomed Sci, Core Lab, Shenzhen 518057, Peoples R China ; [Ogawa, Satoshi ; Parhar, Ishwar S.] Monash Univ Malaysia, Sch Med & Hlth Sci, Brain Res Inst, Bandar Sunway 47500, Malaysia
DOI10.1210/en.2014-1204
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000353131800019
WOS KeywordGOLDFISH CARASSIUS-AURATUS ; KISSPEPTIN/KISSPEPTIN RECEPTOR SYSTEM ; MACKEREL SCOMBER-JAPONICUS ; GONADAL DEVELOPMENT ; NEUROENDOCRINE REGULATION ; GONADOTROPIN-SECRETION ; EVOLUTIONARY INSIGHTS ; TELEOST FISH ; KISSPEPTIN ; GPR54
Citation statistics
Cited Times:80[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23896
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorCheng, CHK (reprint author), Chinese Univ Hong Kong, Room 604A,6-F, Shatin, Hong Kong, Peoples R China.
Affiliation1.Sun Yat Sen Univ, Sch Life Sci, Inst Aquat Econ Anim, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Guangdong, Peoples R China
3.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Peoples R China
5.Wuhan Univ, Sch Basic Med Sci, Dept Genet, Wuhan 430072, Peoples R China
6.Chinese Univ Hong Kong, Shenzhen Res Inst, Sch Biomed Sci, Core Lab, Shenzhen 518057, Peoples R China
7.Monash Univ Malaysia, Sch Med & Hlth Sci, Brain Res Inst, Bandar Sunway 47500, Malaysia
Recommended Citation
GB/T 7714
Tang, Haipei,Liu, Yun,Luo, Daji,et al. The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies[J]. ENDOCRINOLOGY,2015,156(2):589-599.
APA Tang, Haipei.,Liu, Yun.,Luo, Daji.,Ogawa, Satoshi.,Yin, Yike.,...&Cheng, CHK .(2015).The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies.ENDOCRINOLOGY,156(2),589-599.
MLA Tang, Haipei,et al."The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies".ENDOCRINOLOGY 156.2(2015):589-599.
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