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题名: The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies
作者: Tang, Haipei1, 2; Liu, Yun1, 3, 6; Luo, Daji4, 5; Ogawa, Satoshi7; Yin, Yike2; Li, Shuisheng1, 2; Zhang, Yong1, 2, 3; Hu, Wei4; Parhar, Ishwar S.7; Lin, Haoran1, 2; Liu, Xiaochun1, 2; Cheng, Christopher H. K.3, 6
通讯作者: Cheng, CHK (reprint author), Chinese Univ Hong Kong, Room 604A,6-F, Shatin, Hong Kong, Peoples R China.
刊名: ENDOCRINOLOGY
发表日期: 2015-02-01
DOI: 10.1210/en.2014-1204
卷: 156, 期:2, 页:589-599
收录类别: SCI
文章类型: Article
部门归属: [Tang, Haipei ; Liu, Yun ; Li, Shuisheng ; Zhang, Yong ; Lin, Haoran ; Liu, Xiaochun] Sun Yat Sen Univ, Sch Life Sci, Inst Aquat Econ Anim, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China ; [Tang, Haipei ; Yin, Yike ; Li, Shuisheng ; Zhang, Yong ; Lin, Haoran ; Liu, Xiaochun] Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Guangdong, Peoples R China ; [Liu, Yun ; Zhang, Yong ; Cheng, Christopher H. K.] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China ; [Luo, Daji ; Hu, Wei] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Peoples R China ; [Luo, Daji] Wuhan Univ, Sch Basic Med Sci, Dept Genet, Wuhan 430072, Peoples R China ; [Liu, Yun ; Cheng, Christopher H. K.] Chinese Univ Hong Kong, Shenzhen Res Inst, Sch Biomed Sci, Core Lab, Shenzhen 518057, Peoples R China ; [Ogawa, Satoshi ; Parhar, Ishwar S.] Monash Univ Malaysia, Sch Med & Hlth Sci, Brain Res Inst, Bandar Sunway 47500, Malaysia
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: The kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in most vertebrates. However, this presumption has not been tested vigorously in nonmammalian vertebrates. Distinct from mammals, multiple kiss1/gpr54 paralogous genes (kiss/kissr) have been identified in nonmammalian vertebrates, raising the possibility of functional redundancy among these genes. In this study, we have systematically generated the zebrafish kiss1(-/-), kiss2(-/-), and kiss1(-/-); kiss2-/- mutant lines as well as the kissr1(-/-), kissr2(-/-), and kissr1(-/-); kissr2(-/-) mutant lines using transcription activator-like effector nucleases. We have demonstrated that spermatogenesis and folliculogenesis as well as reproductive capability are not impaired in all of these 6 mutant lines. Collectively, our results indicate that kiss/kissr signaling is not absolutely required for zebrafish reproduction, suggesting that the kiss/kissr systems play nonessential roles for reproduction in certain nonmammalian vertebrates. These findings also demonstrated that fish and mammals have evolved different strategies for neuroendocrine control of reproduction.
关键词[WOS]: GOLDFISH CARASSIUS-AURATUS ; KISSPEPTIN/KISSPEPTIN RECEPTOR SYSTEM ; MACKEREL SCOMBER-JAPONICUS ; GONADAL DEVELOPMENT ; NEUROENDOCRINE REGULATION ; GONADOTROPIN-SECRETION ; EVOLUTIONARY INSIGHTS ; TELEOST FISH ; KISSPEPTIN ; GPR54
语种: 英语
WOS记录号: WOS:000353131800019
ISSN号: 0013-7227
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23896
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Sch Life Sci, Inst Aquat Econ Anim, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Guangdong, Peoples R China
3.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Peoples R China
5.Wuhan Univ, Sch Basic Med Sci, Dept Genet, Wuhan 430072, Peoples R China
6.Chinese Univ Hong Kong, Shenzhen Res Inst, Sch Biomed Sci, Core Lab, Shenzhen 518057, Peoples R China
7.Monash Univ Malaysia, Sch Med & Hlth Sci, Brain Res Inst, Bandar Sunway 47500, Malaysia
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