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Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)
Qi, Zhitao1,2; Jiang, Yousheng1,3; Holland, Jason W.1; Nie, Pin4; Secombes, Christopher J.1; Wang, Tiehui1; Wang, TH (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland.
2015-06-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume44Issue:2Pages:389-398
AbstractAtypical chemokine receptors (ACKRs) have emerged as key components of the chemokine system, with an essential regulatory function in innate and adaptive immune responses and inflammation. In mammals ACKR2 is a 'scavenging' receptor for inflammatory CC chemolcines and plays a central role in the resolution of in vivo inflammatory responses. An ACKR2 like gene has been identified and cloned in rainbow trout (Teleostei) in the present study, enabling the further identification of this molecule in another group of ray-finned teleost fish (Holostei), in a lobe-finned fish (Sarcopterygii-coelacanth), and in reptiles. The identity of these ACKR2 molecules is supported by their conserved structure, and by phylogenetic tree and synteny analysis. Trout ACKR2 is highly expressed in spleen and head kidney, suggesting a homeostatic role of this receptor in limiting the availability of its potential ligands. Trout ACKR2 expression can be modulated in vivo by bacterial and parasitic infections, and in vitro by PAMPs (poly I:C and peptidoglycan) and cytokines (IL-6, INF-alpha, IFN-gamma and IL-21) in a time dependent manner. These patterns of expression and modulation suggest that trout ACKR2 is regulated in a complex way and has an important role in control of the chemokine network in fish as in mammals. (c) 2015 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordRainbow Trout Oncorhynchus Mykiss Atypical Chemokine Receptor-2 (Ackr2) Cc Chemokine Binding Protein-2 (Ccbp2) Expression Infection
Department[Qi, Zhitao ; Jiang, Yousheng ; Holland, Jason W. ; Secombes, Christopher J. ; Wang, Tiehui] Univ Aberdeen, Inst Biol & Environm Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland ; [Qi, Zhitao] Yancheng Inst Technol, Dept Ocean Technol, Key Lab Aquaculture & Ecol Coastal Pool Jiangsu P, Yancheng 224051, Jiangsu, Peoples R China ; [Jiang, Yousheng] Shanghai Ocean Univ, Coll Fishery & Life Sci, Shanghai 201306, Peoples R China ; [Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
DOI10.1016/j.fsi.2015.02.038
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000354583800001
WOS KeywordPROLIFERATIVE KIDNEY-DISEASE ; YERSINIA-RUCKERI INFECTION ; TELEOST FISH ; CC CHEMOKINES ; GENE-EXPRESSION ; FUNCTIONAL-CHARACTERIZATION ; ATLANTIC SALMON ; CYTOKINE FAMILY ; IFN-GAMMA ; EVOLUTION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23893
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorWang, TH (reprint author), Univ Aberdeen, Inst Biol & Environm Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland.
Affiliation1.Univ Aberdeen, Inst Biol & Environm Sci, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland
2.Yancheng Inst Technol, Dept Ocean Technol, Key Lab Aquaculture & Ecol Coastal Pool Jiangsu P, Yancheng 224051, Jiangsu, Peoples R China
3.Shanghai Ocean Univ, Coll Fishery & Life Sci, Shanghai 201306, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Qi, Zhitao,Jiang, Yousheng,Holland, Jason W.,et al. Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)[J]. FISH & SHELLFISH IMMUNOLOGY,2015,44(2):389-398.
APA Qi, Zhitao.,Jiang, Yousheng.,Holland, Jason W..,Nie, Pin.,Secombes, Christopher J..,...&Wang, TH .(2015).Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss).FISH & SHELLFISH IMMUNOLOGY,44(2),389-398.
MLA Qi, Zhitao,et al."Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)".FISH & SHELLFISH IMMUNOLOGY 44.2(2015):389-398.
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