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题名: Contribution of nuclease to the pathogenesis of Aeromonas hydrophila
作者: Ji, Yachan1; Li, Jinquan2; Qin, Zhendong1; Li, Aihua5; Gu, Zemao1, 3, 4; Liu, Xiaoling1, 3, 4; Lin, Li1, 3, 4; Zhou, Yang1, 3, 4
通讯作者: Zhou, Y (reprint author), Huazhong Agr Univ, Dept Aquat Anim Med, Coll Fisheries, Wuhan, Peoples R China.
关键词: pathogenesis ; Aeromonas hydrophila ; nuclease
刊名: VIRULENCE
发表日期: 2015-07-04
DOI: 10.1080/21505594.2015.1049806
卷: 6, 期:5, 页:515-522
收录类别: SCI
文章类型: Article
部门归属: [Ji, Yachan ; Qin, Zhendong ; Gu, Zemao ; Liu, Xiaoling ; Lin, Li ; Zhou, Yang] Huazhong Agr Univ, Dept Aquat Anim Med, Coll Fisheries, Wuhan, Peoples R China ; [Li, Jinquan] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan, Peoples R China ; [Gu, Zemao ; Liu, Xiaoling ; Lin, Li ; Zhou, Yang] Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan, Peoples R China ; [Gu, Zemao ; Liu, Xiaoling ; Lin, Li ; Zhou, Yang] Minist Agr, Key Lab Freshwater Anim Breeding, Wuhan, Peoples R China ; [Li, Aihua] State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]: Immunology ; Infectious Diseases ; Microbiology
英文摘要: Aeromonas hydrophila is a gram-negative bacterium that is widely distributed in aquatic environments and can cause septicemia in both fish and humans. However, the underlying mechanisms leading to severe infection are not well understood. In this study, an A. hydrophila nuclease (ahn) deletion mutant was constructed to investigate its contribution to pathogenesis. This mutant did not differ from the wild-type strain in terms of its growth or hemolytic phenotype. However, the ahn-deficient mutant was more susceptible to being killed by fish macrophages and mouse blood in vitro. Furthermore, evidence obtained using both fish and murine infection models strongly indicated that the inactivation of Ahn impaired the ability of A. hydrophila to evade innate immune clearance in vivo. More importantly, the virulence of the mutant was attenuated in both fish and mice, with reductions in dissemination capacities and mortality rates. These findings implicate Ahn in A. hydrophila virulence, with important functions in evading innate immune defenses.
关键词[WOS]: NEUTROPHIL EXTRACELLULAR TRAPS ; GROUP-A STREPTOCOCCUS ; CLINICAL ISOLATE ; VIRULENCE ; IDENTIFICATION ; INFECTION ; EFFECTOR ; MACROPHAGES ; ENTEROTOXIN ; EXPRESSION
语种: 英语
WOS记录号: WOS:000357649400018
ISSN号: 2150-5594
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23885
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Huazhong Agr Univ, Dept Aquat Anim Med, Coll Fisheries, Wuhan, Peoples R China
2.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan, Peoples R China
3.Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan, Peoples R China
4.Minist Agr, Key Lab Freshwater Anim Breeding, Wuhan, Peoples R China
5.State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
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