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Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut
Lin, Juan1,2; Chen, Jun1; He, Jun1,2; Chen, Jing1,2; Yan, Qingyun3; Zhou, Jizhong4; Xie, Ping1; Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.
2015-03-01
Source PublicationTOXICON
ISSN0041-0101
Volume95Issue:1Pages:50-56
AbstractThe short-term exposure to microcystin-LR (MC-LR, one of the most common and toxic variants generated by toxigenic cyanobacteria) induced gut dysfunction such as generation of reactive oxygen species, cell erosion and deficient intestinal absorption of nutrients. However, till now, little is known about its impact on gut microbial community, which has been considered as necessary metabolic assistant and stresses resistant entities for the host. This study was designed to reveal the shift of microbial functional genes in the gut of rat orally gavaged with MC-LR. GeoChip detected a high diversity of bacterial and fungal genes involved in basic metabolic processes and stress resistance. The results showed that the composition of functional genes was significantly changed in rat gut after one week of exposure to MC-LR, and we found some relatively enriched genes that are involved in carbon degradation including chitin, starch and limonene metabolism, and these genes were mainly derived from fungal and bacterial pathogens. In addition, we found large amounts of significantly enriched genes relevant to degradation of the specific carbon compounds, aromatics. The dysbiosis of bacterial and fungal flora gave an implication of pathogens invasion. The enriched gene functions could be linked to acute gastroenteritis induced by MC-LR. (C) 2015 Elsevier Ltd. All rights reserved.
SubtypeArticle
KeywordMicrocystin-lr Rat Gut Microbial Functional Gene Geochip
Department[Lin, Juan ; Chen, Jun ; He, Jun ; Chen, Jing ; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China ; [Lin, Juan ; He, Jun ; Chen, Jing] Chinese Acad Sci, Grad Univ, Beijing 10049, Peoples R China ; [Yan, Qingyun] Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan, Peoples R China ; [Zhou, Jizhong] Univ Oklahoma, Dept Microbiol & Plant Biol, Inst Environm Genom, Norman, OK 73019 USA
DOI10.1016/j.toxicon.2015.01.011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS KeywordPROTEIN PHOSPHATASE-1 ; ANAEROBIC DEGRADATION ; CANDIDA-ALBICANS ; MICROBIOTA ; VIRULENCE ; HEALTH ; INFLAMMATION ; EXPRESSION ; RESPONSES ; PATTERNS
WOS IDWOS:000350922700006
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/23867
Collection淡水生态学研究中心
Corresponding AuthorXie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 10049, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan, Peoples R China
4.Univ Oklahoma, Dept Microbiol & Plant Biol, Inst Environm Genom, Norman, OK 73019 USA
Recommended Citation
GB/T 7714
Lin, Juan,Chen, Jun,He, Jun,et al. Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut[J]. TOXICON,2015,95(1):50-56.
APA Lin, Juan.,Chen, Jun.,He, Jun.,Chen, Jing.,Yan, Qingyun.,...&Xie, P .(2015).Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut.TOXICON,95(1),50-56.
MLA Lin, Juan,et al."Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut".TOXICON 95.1(2015):50-56.
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