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题名: Effects of microcystin-LR on bacterial and fungal functional genes profile in rat gut
作者: Lin, Juan1, 2; Chen, Jun1; He, Jun1, 2; Chen, Jing1, 2; Yan, Qingyun3; Zhou, Jizhong4; Xie, Ping1
通讯作者: Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China.
关键词: Microcystin-LR ; Rat gut ; Microbial functional gene ; GeoChip
刊名: TOXICON
发表日期: 2015-03-01
DOI: 10.1016/j.toxicon.2015.01.011
卷: 95, 期:1, 页:50-56
收录类别: SCI
文章类型: Article
部门归属: [Lin, Juan ; Chen, Jun ; He, Jun ; Chen, Jing ; Xie, Ping] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China ; [Lin, Juan ; He, Jun ; Chen, Jing] Chinese Acad Sci, Grad Univ, Beijing 10049, Peoples R China ; [Yan, Qingyun] Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan, Peoples R China ; [Zhou, Jizhong] Univ Oklahoma, Dept Microbiol & Plant Biol, Inst Environm Genom, Norman, OK 73019 USA
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
英文摘要: The short-term exposure to microcystin-LR (MC-LR, one of the most common and toxic variants generated by toxigenic cyanobacteria) induced gut dysfunction such as generation of reactive oxygen species, cell erosion and deficient intestinal absorption of nutrients. However, till now, little is known about its impact on gut microbial community, which has been considered as necessary metabolic assistant and stresses resistant entities for the host. This study was designed to reveal the shift of microbial functional genes in the gut of rat orally gavaged with MC-LR. GeoChip detected a high diversity of bacterial and fungal genes involved in basic metabolic processes and stress resistance. The results showed that the composition of functional genes was significantly changed in rat gut after one week of exposure to MC-LR, and we found some relatively enriched genes that are involved in carbon degradation including chitin, starch and limonene metabolism, and these genes were mainly derived from fungal and bacterial pathogens. In addition, we found large amounts of significantly enriched genes relevant to degradation of the specific carbon compounds, aromatics. The dysbiosis of bacterial and fungal flora gave an implication of pathogens invasion. The enriched gene functions could be linked to acute gastroenteritis induced by MC-LR. (C) 2015 Elsevier Ltd. All rights reserved.
关键词[WOS]: PROTEIN PHOSPHATASE-1 ; ANAEROBIC DEGRADATION ; CANDIDA-ALBICANS ; MICROBIOTA ; VIRULENCE ; HEALTH ; INFLAMMATION ; EXPRESSION ; RESPONSES ; PATTERNS
语种: 英语
WOS记录号: WOS:000350922700006
ISSN号: 0041-0101
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23867
Appears in Collections:淡水生态学研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 10049, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan, Peoples R China
4.Univ Oklahoma, Dept Microbiol & Plant Biol, Inst Environm Genom, Norman, OK 73019 USA
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