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题名: Characterization of the hypoxia-inducible factor 1 alpha gene in the sperm whale, beluga whale, and Yangtze finless porpoise
作者: Bi, Jianling1, 2; Hu, Bo1; Zheng, Jinsong1; Wang, Jingzhen1; Xiao, Wuhan1; Wang, Ding1
通讯作者: Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China.
刊名: MARINE BIOLOGY
发表日期: 2015-06-01
DOI: 10.1007/s00227-015-2662-4
卷: 162, 期:6, 页:1201-1213
收录类别: SCI
文章类型: Article
部门归属: [Bi, Jianling ; Hu, Bo ; Zheng, Jinsong ; Wang, Jingzhen ; Xiao, Wuhan ; Wang, Ding] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China ; [Bi, Jianling] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Marine & Freshwater Biology
研究领域[WOS]: Marine & Freshwater Biology
英文摘要: Cetaceans have evolved many behavioral and biological adaptations to allow them to survive in aquatic environments. Because of diving and breath-holding behaviors, cetaceans experience wide fluctuations in oxygen tension. However, the molecular basis behind their adaptation to a wide range of diving depths and durations remains unknown. Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. In this study, the HIF-1 alpha gene was cloned from the sperm whale (Physeter macrocephalus), the beluga whale (Delphinapterus leucas), and the Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis). HIF-1 alpha from the deep-diving sperm whale degraded rapidly under normoxia but remained stable during hypoxia compared with HIF-1 alpha from the beluga whale and the Yangtze finless porpoise. Sperm whale HIF-1 alpha also responded to reoxygenation significantly faster and exerted more potent effects on the transcriptional activity of some gene promoters compared with HIF-1 alpha from the beluga whale and the Yangtze finless porpoise. Mutations in HIF-1 alpha were detected between the Yangtze finless porpoise and the sperm whale, which may determine their functional differences. The results suggest that the response of sperm whale HIF-1 alpha to different oxygen tensions is more variable than that of Yangtze finless porpoise or beluga whale HIF-1 alpha, indicating that the rate of degradation of HIF-1 alpha may be more variable in long-duration divers than in short-duration diver cetaceans. Because of the lack of whale models and whale cell lines, all experiments were conducted in vitro using human embryonic kidney 293T cells.
关键词[WOS]: ELEPHANT SEAL PUPS ; DIVE-ASSOCIATED ISCHEMIA/REPERFUSION ; GROWTH-FACTOR EXPRESSION ; RINGED SEAL ; OXIDATIVE STRESS ; FACTOR-I ; CLONING ; CETACEANS ; TISSUES ; PROLYL
语种: 英语
WOS记录号: WOS:000354619600005
ISSN号: 0025-3162
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/23823
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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文件名: Characterization of the hypoxia-inducible factor 1 alpha gene in the sperm whale, beluga whale, and Yangtze finless porpoise.pdf
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