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题名: The Mitochondrial Thioredoxin is Required for Liver Development in Zebrafish
作者: Zhang, J.1, 2; Cui, X.2; Wang, L.1; Liu, F.1; Jiang, T.1; Li, C.1; Li, D.1; Huang, M.1; Liao, S.1; Wang, J.1; Chen, J.1; Jia, H.1; He, J.3; Tang, Z.1; Yin, Z.3; Liu, M.1
关键词: Apoptosis ; Bcl-2 family ; liver morphogenesis ; MPP ; Trx2 ; zebrafish
刊名: CURRENT MOLECULAR MEDICINE
发表日期: 2014
卷: 14, 期:6, 页:772-782
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
英文摘要: Thioredoxins (Trxs) are a class of small molecular redox proteins that play an important role in scavenging abnormally accumulated reactive oxygen species (ROS). Thioredoxin 2 (Trx2) is one member of this family located in mitochondria. Trx2 protects cells from increased oxidative stress and has anti-apoptosis function. Knockout of Trx2 in mice led to early embryonic lethality. However, the essential role of Trx2 during embryogenesis remains unclear. To further investigate the role of Trx2 during embryonic development, we performed Trx2 knockdown in zebrafish and investigated the regulation role of Trx2 during embryonic development. Our results indicate that Trx2 had a high expression in early zebrafish embryos and its knockdown in zebrafish led to defective liver development mainly due to increased hepatic cell death. The increased ROS and the imbalance of members of the Bcl-2 family were involved in cell death induced by Trx2 suppression in zebrafish. The dysregulation of Bax, puma and Bcl-xl promoted the reduction of mitochondrial trans-membrane potential and the mitochondria membrane permeabilization (MMP), which initiated the mitochondrial apoptosis pathway. Additionally, we found that the increase of relocated GAPDH in mitochondria may be another factor responsible for the mitochondrial catastrophe.
关键词[WOS]: OUTER-MEMBRANE PERMEABILIZATION ; CELL-DEATH ; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ; OXIDATIVE STRESS ; APOPTOSIS ; BAX ; NUCLEAR ; PUMA ; EXPRESSION ; REDUCTASE
语种: 英语
WOS记录号: WOS:000341015600007
ISSN号: 1566-5240
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/20390
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Ctr Human Genome Res, Key Lab Mol Biophys,Minist Educ, Wuhan 430074, Hubei, Peoples R China
2.Henan Univ, Coll Med, Inst Immunol, Key Lab Cellular & Mol Immunol, Kaifeng, Henan, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
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